ID M1ZGY5_9FIRM Unreviewed; 823 AA.
AC M1ZGY5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Putative DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:SHD77458.1};
GN ORFNames=CUESP1_2101 {ECO:0000313|EMBL:SHD77458.1};
OS [Clostridium] ultunense Esp.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Tepidimicrobiaceae;
OC Schnuerera.
OX NCBI_TaxID=1288971 {ECO:0000313|EMBL:SHD77458.1, ECO:0000313|Proteomes:UP000245423};
RN [1] {ECO:0000313|EMBL:SHD77458.1, ECO:0000313|Proteomes:UP000245423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Clostridium ultunense strain Esp {ECO:0000313|EMBL:SHD77458.1};
RA Manzoor S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LT669839; SHD77458.1; -; Genomic_DNA.
DR RefSeq; WP_005587881.1; NZ_LT669839.1.
DR AlphaFoldDB; M1ZGY5; -.
DR HOGENOM; CLU_010363_2_1_9; -.
DR OrthoDB; 9761531at2; -.
DR Proteomes; UP000245423; Chromosome chri.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000245423};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 524..727
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 823 AA; 93695 MW; 460FFD101D89613B CRC64;
MRRPFVLFTI PIVLGIIFYY YFHTNIYLIL ALFLLTLIIN IIGVKLGERV SIAVFVSLFL
LGILITGIKM EGSRLAKHVE RPIELMGSVK EVKSVSKGAG RYVIKVHKAM DNGRKIKVSE
KALLKVLGEE ELEIGSKVKF RGVLKEPLPN TNPRLFNYKL NLLADNIYTT ITIKDYSITG
IEKENINFLL RLRKGFINKV EEGLDLYLSE ENSSLMKSIL LGKYSYLDEE TIQQFRDLGL
AHILAVSGLH IGIIASLVTT LLAYSGMNRK FNISLAIGIL WIYGFIIGNP VSVLRANIMF
TILLISQLGA EPYDSINTMF FASFILIIIN PFWIFNLGFQ LSFIATFSIL YFTEKISAIL
YLNDNSILKS LLGILSVQIG LLPILVYYFN RIPTIGLMAN LVLIPIFTIC LILSIFLIFF
SLFGSSIAYS IGVLVNFLLK AQFNSIKILS YFPILNIKAP SPSIFGILIY YVMVLILFGV
INIRKFNIRV NKAIIFYLLF IILVNALLFN LDSSLAVNFV DVGQGDSILL KTKEGYYLID
TGGNIFGDFD IGKSILLPYL EKEGIFKLKG VFISHFDADH CKNLPYLIDN IKIENIYFGY
EREENDLYRQ IVGKALKKEI PIRVLKKGDK LKLDEDINIY VIGPSDNILT NPNTTDNDLS
LVLLLNYYDY NILFTGDIER LGEENVQDSL NRDIDFLKVP HHGSNTSSGE NFLYSLNPNI
GFASVGRNNS FGHPHKEVLD RYKTHNVEVY RTDELGLINL TLNKYGYKIV PFLRDKWSII
DIVQDYSSYI IYLIFYFFLS YKMAIEFLLI EEEMAKIELQ GIY
//
