ID M2LKD6_BAUPA Unreviewed; 1385 AA.
AC M2LKD6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BAUCODRAFT_25859 {ECO:0000313|EMBL:EMC94732.1};
OS Baudoinia panamericana (strain UAMH 10762) (Angels' share fungus)
OS (Baudoinia compniacensis (strain UAMH 10762)).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Teratosphaeriaceae; Baudoinia.
OX NCBI_TaxID=717646 {ECO:0000313|EMBL:EMC94732.1, ECO:0000313|Proteomes:UP000011761};
RN [1] {ECO:0000313|EMBL:EMC94732.1, ECO:0000313|Proteomes:UP000011761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 10762 {ECO:0000313|EMBL:EMC94732.1,
RC ECO:0000313|Proteomes:UP000011761};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; KB445558; EMC94732.1; -; Genomic_DNA.
DR RefSeq; XP_007677965.1; XM_007679775.1.
DR STRING; 717646.M2LKD6; -.
DR GeneID; 19110350; -.
DR KEGG; bcom:BAUCODRAFT_25859; -.
DR eggNOG; KOG2108; Eukaryota.
DR HOGENOM; CLU_255324_0_0_1; -.
DR OrthoDB; 208346at2759; -.
DR Proteomes; UP000011761; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000011761}.
FT DOMAIN 533..805
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 806..1116
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 81..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 554..561
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1385 AA; 152741 MW; 30AAFFA6E03D6EE4 CRC64;
MPARTVSVTK AVKDVKQRWE YLARWRREGS TNLISAYNRK YRADLQVFVG AHGVSLSAKQ
LDDLPSPEDV IHLMISAKRP CTKTPKSKAS LPAGEISVPT KTAKLSEKRK AENDPSSDMR
SLKQPKLPDA TSSKSPQPAQ SIQQPGQKRS AETDPEGLRS TKRAKQAHIP FSGLINHAQA
CYSIASIQFP DAATRRQELR SLFGDGEKPD AFATSRSIHG YLPNTSRERD HCAMPLIACV
TPSEWLPEML ESRVASEQSV SAYLLQTVFA FGGPGDLPVS ISGEMRDVCE KACGHMATPQ
TTESNYHGIT VPLSSAVKGP ASLASVLNAS LRSETEQTCP VCKDNHLMRH SKITSDPERL
VVKLERGTSD AGKLAKSQAA VDCNNTSDST FGDSRYEVTA AIVRHGASTQ VGNYVVFREQ
GKRRQGGLVE HATPAEEAII GCHSCHMADG ASQIDASRRH IQCRTQVLMS VGMARSFKCN
AGDDDLYWRR SSLQSTTLCH NMRRLLQDLI MAIITTYKAI EHIPLRMESD ILDGLNAAQR
TAVTSDADVL QVLAPPGSGK TKTLTARVAW LLGDRQLKPW NIIVCTFTVK AASEMKQRIT
NFVGEECAKQ LRLGTFHSVA VRYLRRYGQL IGLNKDFGIA DASDSKAIIK RIIKQQGLTI
DDGPSRSRIS AQKARGINSQ RYAQAAKKAD QEFLQVYQEY EATLVASNLL DYDDLILRCC
DLLRAHPDCV ANVEALLIDE FQDTNTIQYE LMALFAQRRN VITIVGDPDQ SIYGFRSAEI
QNLNRMTKQW PDTLTINLEE NYRSSGAILH AAQHIIEQDT DRPPKKLQAT HTFGLRPVLR
KLPSAPAEAA WLVAEVKRLM ALTGDLLQPS DFAVLLRSAA LSRVIESALG KEGVPYRMIG
GTKFYDRIEV KTLIDYLRVI ATPDNSEAVE RVINVPPRRI GDASVESLHK EARKLNISLW
RLVLDTAQGR SKPTTKLPSS TMKGLESFAD VVLTCRKKLA NAEGACLIEL INTVLKKLSY
QDWLKKKYPD DHDTRWTNVE ELLAQATDAS ESGRMQAEFE NHSPTPAVEQ EPLTLNDALS
AFLANIALTT SSAEKTEHEG QPTQQLTLST IHAAKGLEWP VVFIPACYDG SIPHSRAEDH
DEERRLLYVG MTRAQAVLYL STPLKDSQRA ETCTSKFLTE PGVARFFEEH GPAIAGRDVQ
GLARTLHRTC PDTAAIRATA QFLARDQDNY WPLDGEEPPE ERDKWNYGRQ STISAAFGGF
QAASSVLTNA ATAGQQHVLS TANATTQPGF VSCRDRYQEA LGEAQLKKVD KRAEEQARAS
AANKPKGRKR QMEGQGTLSS FFGKPDASTS AYQDKRTDSQ DDPAASARTL RSPSYPIPAR
TEAIP
//
