ID M2R2F3_COCSN Unreviewed; 1495 AA.
AC M2R2F3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=COCSADRAFT_148121 {ECO:0000313|EMBL:EMD61414.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD61414.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD61414.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB445648; EMD61414.1; -; Genomic_DNA.
DR RefSeq; XP_007702769.1; XM_007704579.1.
DR STRING; 665912.M2R2F3; -.
DR GeneID; 19131439; -.
DR KEGG; bsc:COCSADRAFT_148121; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_004183_0_0_1; -.
DR OMA; EFQFRPM; -.
DR OrthoDB; 1422944at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016934};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 672..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..765
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 970..993
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 72..105
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 644..802
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..379
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1495 AA; 165401 MW; 0FF0836C397FC5C0 CRC64;
MAKTKPADRK AKKGAKSSVK AGASKPKVSA EDLLIQAATL LQTSQPEEAL IAAQRALNLV
QPGTSKPSAA ALPALNLIGE INVELGDPDS AREAFQAAII IDPEGTHDGA EKFLWMAQLN
EEGGAESVRW FEKGIEVLKR EIGGLEGKMV KNNEIAELVE EKRQKIANSL CGIAEVYMTD
LSWEEDAEAR CDAAVTEALL FAPENPEPLQ TLASIRISQL KPDEARSALR RSMELWKDLD
PDDAKVPDYS LRISLSRLLM EAEMEDEAIE VLERLVGEND GSVEAWYLGG WCLHLLAGKQ
KAKGEEKVTT SLLRASRDWL ENCLKLYAML EYEDERLKEH ADELLRELND VLGPSIGAEE
EEDEWEEDDG DEDEDMDETT TEPPRLSTSH PIRRAFQAHG TATARHWLLS IFVTIIISVL
LCYQAVFQAD SSAAAGLRNL PKHVWTSTTQ VEGERIPDVI VRQVWVHGDY MKAIELPVLR
QALHVQEALI NGGFNKDADD DANALRNTLA STTSGCMAAG PQEKWTWHSP LMYWNCSRSA
LDSDDDLLGT INTHTRMRTP RNITLRPSTV FAGKSFSNTK LRAADALVIT LFDQNSSRLG
AIWDARARTL TEEISADWAV FPHDGQVTRS RLFEFRFKSM TLNDDLFLAA SYLITAIYVI
TRMRQLRAVK SWFGLLITIC MKMTVCVIAS FTLCTYLGID LARIPRPWFP VVVFCFGLGN
IFRLINVVLE TPPEMPPHQR IGNALGEVGH LSVAIAFQNL ALLYFCSRLV TPWVADFCVF
AAVTLVFDLV FHLTFFIAVL SVDVQRMELS DSLDRINLSQ STKNKQAERQ SWLGALREGT
LPLSTRFAGT VAIFSVILAV NWHFFDSGDK LLSFNTLRQS FTSRRRKRSI DTSWSHSPIN
QARTPADWLR LQDHNTAQEL FSFIKPGAQT FVARIYNPIL VVSKGAQGRD RPQPPSSLVE
GFRRFAHGHA FPAALITVTL IAIVALFMNY LLWTGLPIDA EENDDVETEF SVKTLPTPQN
LDVVQLAGCP KGHLASTASM KPRLWPIYAT AIDDGGSMLA ICGQTGQIGL WDIPASRFLM
FPLIDIRGQA PIRFSFVTLR TRTDVERLYL IIVSPDGHLT KLEARTGIHH TRRIATSSIV
CSSIYTSEKG DTSLAFVTKA GEVHILSLKQ EDNYTSEVVA GLDPGPPPGS NPAKIRCIYA
VPSLGVMFAL RDEEAEIFDF SSRALVHAFQ IGHVRPHSFR VLHSVRRVCQ CGAPAVNSLS
VAYAEHSANH MVMQTFSLDD KTTSQMCLGK PLDREKHKCR SLECAKEAVY SVEPAGVWES
TEAQSVIGVR RRAQLATPSS THSGAEENYT GVDAVALASA LKQRAQRQGH VNLSRFGDGA
LTKIDPMDNS FEDSDAWEVW TLSTAGDFRS RPLVPDDADD VATESYEDEL FVAAPGPIVK
LGKRSIAVGF GNTVKVVTLG KESFDGLTSV QSSAMDVGLG SYKWRARKAS GRKVQ
//
