ID M2RHP2_COCSN Unreviewed; 1702 AA.
AC M2RHP2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCSADRAFT_179587 {ECO:0000313|EMBL:EMD66264.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD66264.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD66264.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
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DR EMBL; KB445640; EMD66264.1; -; Genomic_DNA.
DR RefSeq; XP_007697798.1; XM_007699608.1.
DR STRING; 665912.M2RHP2; -.
DR GeneID; 19133205; -.
DR KEGG; bsc:COCSADRAFT_179587; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016934}.
FT DOMAIN 363..487
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1454..1698
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 39..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..880
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..968
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1373..1389
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1408..1425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1444
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1702 AA; 188281 MW; 67947B99073E6EF4 CRC64;
MALPALPQNN SDIAAPCSPV HTAKRDILPA AATVAAAAAA TAPGAASENA KRRADDSRRL
RRVKDSREQL KSRTRARGTS NATIDTTTSN STAAGRSYTV ANVHNGVIYL RPVARPGNQR
GRSQPDAFVF PPQTPPDSAT RDTLRPLSDD LDHGFYGSSS PQSEPSPPLP GLSEDEVAAH
YSHHYHHNYH QNNTQYPPHS AHTRSHSFSI ADDHIPASLT NEPGTFKVVI ERPGHVRPKT
ADTSSFPMLQ VPIPHYRLGT PRFSTRGTVD LRSSIYTGTS GTEDFANSLL VTQHSARQSF
LSSRTRSDAY SPVPHRFRAT MDRPPIPLSG PSSARVSHFP IGPRLYDALT LNPDDRAVVR
FNAKGDILAA TPSRLVAHIT SPSFLDYELL SDFFLTFRAF LCSRDLVAYL IARLRWAVDR
QDDFGRIVRV RTFVALRHWI LNYFVDDFMP LYRLRVIFCD LVNSLYSDLR ARKDGGGGDI
NIVGELKKCW RRTCALYWET NDPVGRNYAD DPLLPGGTDE GSQMLFEEPP AVQPMPSTPP
RATVRDTKET IGSNPSDHFA SRYMDWAQRS RHTPQNSMST PFLPSQDNES AQVPLSPASE
RSMHILSCSI PKRGVNKHDQ NVELPLYPHP VPAVNPVPTA TARLAGSPQQ PVSMKNSQRP
ARAHKRSGSF SDALRDSRAP LSIPKNTPAD YTISAVANMP GTLVRGGLIQ PTTPYFQVKT
LRTAPSRHFH EPEDLDVSEL QRPGQANSPG MKKILGSVRR ALSTRQQASV GSHLSGSLQQ
RQPPYGRSSN PGAVPAVSMS GGVQKRRTTR PRPQMRVDVL AATVAESFRR AVEEQLQSEG
QELNDGDAPS LNGFEFEFDG RETPTQNDHQ QPRRKPDPRV HSNITSGSKS IVIIDDTGAP
PLPTTGPLPT ELDKVAAKLD SHQRDASNDE SQADDANSIQ HSYLYDDPDP HAATEEYRRS
RTPTRQSNAR ERRSMSAGPE GMHSFRRKGS FKNSLARAGS LRRHASYNSV LSRRGPASVA
TFQTMSSDND PFFLDRQPTA ESAGPTRQLR RRPGGDLRAA DNVHDLEQVQ RPYSTGSVSN
HTHSITNSVI LRADRFIDSD PELSHGVQGP PEAETPRKPI SLVDTHSSQP NLRPSFEAEV
AKLAALPDDT DDEGGVESAL MKLEGRYEKK SPSIPSQRTT IDFGHHHATQ SFSQSSRLDA
FEHDNRPATD DVFHRPLAPP ETDGQGMYRL SAENFNRRVP PVTSVGESTD SYSSIPLLDR
HLSEMASLQR GQTLDSIASS AKPSPLQVGA FPLQAGRPPG TSSSMNSSIE YVEETDSMRR
IPAGETLPAH SYVRESFLMN DDEDLSDGFS TSAAHFLDGQ QETPEGVPGN LPTHPMRHPP
TPPPTAPQLH DSLPNSTVFD EGLPTPGLTP TVSLSNQQGN PQPERPASSP DEPRTVPADP
PEPTTHLPFV MAYDSDLLAQ QFTIVEKDAL DEIDWKELIE LRWKQSSPQI RDWVQYLRTE
EARGVDVVIA RFNLVVKWVV SECLLTENIY ERAQCITKFI HIANHARRYR NYATMYQIAI
ALISNDISSL KKTWALVPAA EMLVMTELEA LVQPMKNFHN LRLEMETASV EDGCIPFIGV
YTRDLIYNAQ KPAFIDAPPV DGERLVNFDR HHMAATIVKN LLRLLEASSK YTFKAEPHIL
SKCLWLAALS DEEIHERSRQ CK
//
