ID M2RJA5_CERS8 Unreviewed; 1643 AA.
AC M2RJA5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 03-MAY-2023, entry version 27.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
GN ORFNames=CERSUDRAFT_48098 {ECO:0000313|EMBL:EMD38542.1};
OS Ceriporiopsis subvermispora (strain B) (White-rot fungus) (Gelatoporia
OS subvermispora).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Gelatoporiaceae; Gelatoporia.
OX NCBI_TaxID=914234 {ECO:0000313|EMBL:EMD38542.1, ECO:0000313|Proteomes:UP000016930};
RN [1] {ECO:0000313|EMBL:EMD38542.1, ECO:0000313|Proteomes:UP000016930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B {ECO:0000313|EMBL:EMD38542.1,
RC ECO:0000313|Proteomes:UP000016930};
RX PubMed=22434909; DOI=10.1073/pnas.1119912109;
RA Fernandez-Fueyo E., Ruiz-Duenas F.J., Ferreira P., Floudas D.,
RA Hibbett D.S., Canessa P., Larrondo L.F., James T.Y., Seelenfreund D.,
RA Lobos S., Polanco R., Tello M., Honda Y., Watanabe T., Watanabe T.,
RA Ryu J.S., Kubicek C.P., Schmoll M., Gaskell J., Hammel K.E., St John F.J.,
RA Vanden Wymelenberg A., Sabat G., Splinter BonDurant S., Syed K.,
RA Yadav J.S., Doddapaneni H., Subramanian V., Lavin J.L., Oguiza J.A.,
RA Perez G., Pisabarro A.G., Ramirez L., Santoyo F., Master E., Coutinho P.M.,
RA Henrissat B., Lombard V., Magnuson J.K., Kuees U., Hori C., Igarashi K.,
RA Samejima M., Held B.W., Barry K.W., LaButti K.M., Lapidus A.,
RA Lindquist E.A., Lucas S.M., Riley R., Salamov A.A., Hoffmeister D.,
RA Schwenk D., Hadar Y., Yarden O., de Vries R.P., Wiebenga A., Stenlid J.,
RA Eastwood D., Grigoriev I.V., Berka R.M., Blanchette R.A., Kersten P.,
RA Martinez A.T., Vicuna R., Cullen D.;
RT "Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete
RT chrysosporium provide insight into selective ligninolysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5458-5463(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
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DR EMBL; KB445795; EMD38542.1; -; Genomic_DNA.
DR STRING; 914234.M2RJA5; -.
DR HOGENOM; CLU_000844_0_1_1; -.
DR OrthoDB; 354539at2759; -.
DR Proteomes; UP000016930; Unassembled WGS sequence.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR003440; Glyco_trans_48.
DR PANTHER; PTHR12741:SF29; 1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 1.
DR SMART; SM01205; FKS1_dom1; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016930};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EMD38542.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 267..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1116..1134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1271..1301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1377..1397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1409..1436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1448..1472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1552..1571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1605..1629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..233
FT /note="1,3-beta-glucan synthase component FKS1-like"
FT /evidence="ECO:0000259|SMART:SM01205"
SQ SEQUENCE 1643 AA; 187834 MW; D8F93886772EE00F CRC64;
MSTEEIEDIF LDLAQKFGFQ RDSMRNMFDF LMQLLDSRAS RMTPDQALLT VHADYIGGPH
ANYRKWYFAA QLNLDDAVGQ SQNPGLQRLR SVKGAVKTAG TKSLDSATNR WRNAMNNMSQ
YDRLRQVALW LLCWAEAGNV RFTPECLCFI FKCADDYYRS PECQNRVDPV PEGLYLESVI
KPLYCFMRDQ GYEVVEGKFV RKEKDHDQII GYDDINQLFW YPEGLAKIVL QDNTRLIDIP
PAQRYTKFSR IAWNRVFFKT FFEKRSIAHL LVNFNRVWIL HVAVYWFYTA FNSPKVYAPT
PTTDPSPAMT WSATALGGAV ATLIMIFATL AEFSYIPTTW NNASHLTTRL IFLLIVLALT
GGPTVYIIIV DGPKNKSNIP LIIGIVQFFV SVVATIAFGI IPSGRMFGDR VAGKSRKYMA
SQTFTASYPK LSGSARTGSV MLWLLIFGCK FVESYFFLTS SFSSPIAVMA RTKVLGCNDR
YFGSALCSNQ VPFALTIMYV MDLVLFFLDT YLWYIIWIVV FSVTRSFYLG LSIWTPWKEV
YTRMPKRIYA KLLATAEMEV KYKPKVLVSQ VWNAIIISMY REHLLSIHHV QRLLYHQVDG
PDGRRTLRAP PFFTHNNGNE SDFFPAGGEA ERRISFFASS LHTALPEPLP VDAMPTFTVL
VPHYSEKILL SLREIIREED QNTRVTLLEY LKQLHPVEWD NFVKDTKILA EESTAATTTF
DGTASTNEKG NTRTDDLPFY CIGFKTAAPE YTLRTRIWAS LRAQTLYRTV SGMMNYAKAI
KLLYRVENPQ IVQRFAGNTD RLERELERMA RRKFKFAVSM QRYAKFNKEE LENAEFLLRA
YPDLQIAYLD EEPGPKGSDP RLFSILIDGH SEIDETTGKR KPKFRVELPG NPILGDGKSD
NQNHAIIFYR GEYLQLIDAN QDNYLEECLK IRNILGEFEQ YSISSQSPYA QWGHKEFHKD
PVAIVGTREY IFSENIGVLG DIAAGKEQTF GTMTPRTLAW IGGKLHYGHP DFLNATFMTT
RGGVSKAQKG LHLNEDIFAG MTAIGRGGRI KHSEYYQCGK GRDLGFGTIL NFQTKLGTGM
GEQMLSREYY YLGTQLPLDR FLTFYYGHPG FHINNIMVMY SIQIFMVTLL YIGTLNKELA
ICKSSSTGDV LPGEHDCYNL NPVFDWIHRC IVSIFLVFFI AFLPLFLQEL LERGTGKALI
RLGKHFLSLS PIFEVFSTQI YSQSILSNLT FGGARYIATG RGFATTRISF SILYSRFAGP
SIYMGMRNIL LLLYASLAMW SPFLIYFWVS VLSLCIAPFL FNPHQFSFAD FVVDYREFLR
WMSRGNSRTK ASSWYGYCRL SRTMITGYKK KKLGHPSEKL SGDVPRAKWR SVIFSEVVWP
ICHATIFVVA YMFVKSFPID GKMPPSPLIR IAIIAVGPVV WNAAMLLALF FISLFLGPML
ESWAKFPSVM AAIAHFLALV GLIAFFEFFW FLELWDASHA VLGVISIIAI QRAIQKILIA
VFLSREFKHD ETNRAWWSGK WYGRGLGTSA LSQPAREFVV KIVEMSLWSS DFLLGHILMI
ILTPPTLVPF IDKLHSTMMF WLRPSKQIRP PLFSTKQKRQ RRWIVFKYTI VYIIVVAGLA
ALIVLPALFR DDIKFTCTLC QNI
//
