ID M2RLG6_COCSN Unreviewed; 788 AA.
AC M2RLG6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=COCSADRAFT_197277 {ECO:0000313|EMBL:EMD67484.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD67484.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD67484.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; KB445639; EMD67484.1; -; Genomic_DNA.
DR RefSeq; XP_007697133.1; XM_007698943.1.
DR AlphaFoldDB; M2RLG6; -.
DR STRING; 665912.M2RLG6; -.
DR GeneID; 19134008; -.
DR KEGG; bsc:COCSADRAFT_197277; -.
DR eggNOG; ENOG502QWTH; Eukaryota.
DR HOGENOM; CLU_009919_1_1_1; -.
DR OMA; AECGWED; -.
DR OrthoDB; 1353379at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF758; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016934}.
FT DOMAIN 116..555
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 88461 MW; 10A7F9C59C59BAB9 CRC64;
MHGVSRFLSR RDKHGEKRAS KHAKSKSQSP DTPLDLYRIF TSEGPRPPAN EHAEKNVKML
LTRLHGSGIT KMAEEQAEHA LAWYPDDLDK AYDLLVLANE SLEGELKDYN PNVPMLGAIN
RNMVTCYLDA LLFAMFARLD SFEAMLYDNF EDEPRKKLAA VLRLWVNLLR TGQLIRVDLT
KHLQDSLARC GWEDAAQVRQ QDASEAFTFI TGALELPLLT LKMDIYHTGR EDKEDDHKFV
NERLLEVAIP EPEEGRIVTL EDCLETYFNN RIEVKRYLQR QNTIASIRST RDEFTGKDPE
KNESIHIETT EVDAPMTPII ASPISLEPTT TVAPVRPELE GRRRADSIFG KRYLRQPPEA
QMFDEKKHVE DMLDNSSGGR PRSASLLKKE ILMPAWQFFS LIPWYTDNVP RSDAQVAAHF
SAKRPVLGIC LKRYTMNSNG TPKRLDTYID IPLDIGLPHF ISDERMKEEG PLFGNFKLVL
QSVVCHRGVS VDSGHYIALV RANARGRPGT ANSESDEEEA KWLRFDDLSS QRVTEVSIEQ
ALHEESPYLL FYQVQPIDEE LASRGDPPTY TEAQSRIPSV DPSRETLASL PSTTTIDVDT
TGDWEKISVP DAHTEPNRTD EPASRNSTSS NWRSSITIDD GEGSLRGRTQ PTTPAEDKTG
FLSVSRRGSR IWMSGAGKSR PGSPSGENRL SITLSRLTGR GSNNKPITTE GVSVGDELSV
VIDKATSPEG SQKSLSPVKE KKESGISRSK SKKEKKDRMR SKSREPGAVL DKGKSKGKTR
PDRECIVM
//
