ID M2RNC1_CERS8 Unreviewed; 2841 AA.
AC M2RNC1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=CERSUDRAFT_148314 {ECO:0000313|EMBL:EMD40361.1};
OS Ceriporiopsis subvermispora (strain B) (White-rot fungus) (Gelatoporia
OS subvermispora).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Gelatoporiaceae; Gelatoporia.
OX NCBI_TaxID=914234 {ECO:0000313|EMBL:EMD40361.1, ECO:0000313|Proteomes:UP000016930};
RN [1] {ECO:0000313|EMBL:EMD40361.1, ECO:0000313|Proteomes:UP000016930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B {ECO:0000313|EMBL:EMD40361.1,
RC ECO:0000313|Proteomes:UP000016930};
RX PubMed=22434909; DOI=10.1073/pnas.1119912109;
RA Fernandez-Fueyo E., Ruiz-Duenas F.J., Ferreira P., Floudas D.,
RA Hibbett D.S., Canessa P., Larrondo L.F., James T.Y., Seelenfreund D.,
RA Lobos S., Polanco R., Tello M., Honda Y., Watanabe T., Watanabe T.,
RA Ryu J.S., Kubicek C.P., Schmoll M., Gaskell J., Hammel K.E., St John F.J.,
RA Vanden Wymelenberg A., Sabat G., Splinter BonDurant S., Syed K.,
RA Yadav J.S., Doddapaneni H., Subramanian V., Lavin J.L., Oguiza J.A.,
RA Perez G., Pisabarro A.G., Ramirez L., Santoyo F., Master E., Coutinho P.M.,
RA Henrissat B., Lombard V., Magnuson J.K., Kuees U., Hori C., Igarashi K.,
RA Samejima M., Held B.W., Barry K.W., LaButti K.M., Lapidus A.,
RA Lindquist E.A., Lucas S.M., Riley R., Salamov A.A., Hoffmeister D.,
RA Schwenk D., Hadar Y., Yarden O., de Vries R.P., Wiebenga A., Stenlid J.,
RA Eastwood D., Grigoriev I.V., Berka R.M., Blanchette R.A., Kersten P.,
RA Martinez A.T., Vicuna R., Cullen D.;
RT "Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete
RT chrysosporium provide insight into selective ligninolysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5458-5463(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB445792; EMD40361.1; -; Genomic_DNA.
DR STRING; 914234.M2RNC1; -.
DR HOGENOM; CLU_000249_0_2_1; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000016930; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016930}.
FT DOMAIN 1449..1640
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 106..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 481..508
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 120..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2841 AA; 316378 MW; 6801F88B30C0F64B CRC64;
MGVYLGVPRA NAHALATQTA SGGVCTESAW RRGADGWRAA PAAAERCDLC PRLSAHTASS
APAPFLLWAG LGLPRPRRQR PPPPPLPVLS AATDTPRRLP AFQAMPSRRA SAGHSAAAPS
SRVHRSNGSN HSVSAQSPLI SQQSLPFSAS SGLPSSPQQK VVQVLVNRLK NKLPCNSGIT
LTELEDDDAI QQAVESLVDL SRDSLDTIAW SLSELLDKLS KQIDSQGYRS IDVLQSQLFI
MKVLSIAMAS RWGRRPEDTR PSSRNGKQPA PSSKASTPDS ATLPVSIKRR VKLSSDHLSA
PAEPPPLDET CAKYILSVLV LYLRQTAPSA PRMMSSANLD FAASYHDFES VEAPDEHAAT
DVFSRGPTVP PSISAIPRAM NRARHASQAS LNSGAPTNAS GHAARHSLAY EKTSIVTSKS
PLSLNTLIGK FAGRVVYHLS ASNWQIVLTR IRQRIHFLAG ASENDPDIVD LQLMAHSALD
KTRLTQSLQE LSSLLVNMKR EAQAAVARPL RAAIWNWIDL FPEELNDVVR YHRRLDGAPE
RVFDILYDVH DMDKDMKEPP RDSKEIKSAV WPTLTALMCI SSDRIKSELQ GPQKHGRSKD
RNFAELIIRS VAFKSKNRDV AAICALDVCR AASRIRPEED AEIPLQALAL DVAHELKIAL
TKWQNDRPVW DSPDEIDVAM VGDILVTLFR FLEEHESIPI FMTCLQPERS EAVKISAVKA
LITLIVEAPR LPWQPPLENL KAATMGRIAK IYRSCTLRRS ELDEHGFGRK SALRPKAKRY
TSETLPDREL LALSIDALWR ADNWWFLHAL DASFMQYWIP DTIEIWHSQL DPACKISMAR
TYRGVFRTIA KMPADHPHFD TVALWIKHSR PASLATVCTN LLDARTDLQA QRMWINMAYE
FMFGYVQQYE EHLRAVQLNL DRVPAFALAE IAFLVALTSA DSTVSLTAAH CLRLIAQAER
MPNAPISSTL SEEERVKRYP IYEQLGDPKV TVVGRVGYQK RIRKLMRLMT FPSPVHIAVW
EECYWRWCSL NEMVTRLSLD STADGFEGGT TYIGENSMSA DDRQAQWQNL TLFLSSFGSA
CIRETHDPSS LANMITSYYL PDQMRVLRDP RALLSSFLTD LINLLVSESI FPRDVGRDAL
GSEANPRLYT MILKQLDSVV TQLTDGDSID WEGLALFLEQ YILILKVIVE NVQNLEELRG
VDLASTLLTV AGLIRRFNIP ESYKLKIKFC ELCDSVFGRA ETLIMRKDSS SRQRLVDVIV
EWAQDPVTSQ DREPLSPLQQ LNVAVFRTAV RLFDKLKLEP AEGAAGEEAT HANSRLFIKY
SSFLMKAWEF TRSDSSALDD TTSEKSVSHL RVLQREGELR ELLIVGLASL ISTNTECGVK
HTLPYAYEDD PVKRSIFAQV FTRVLAQGAK FSSQGTEPII SRQSRLCELV KGPDLILALT
VCEICPASEV DNMIAVLLNI FDTRSSLMCL LKMMIDLEVS RTDVDTHLFR SNSTCTRFLS
AFARIYGYNY LRSLIIPLVD TMSTLPEGRR YDLDPSKISE VELQQNKENV QLVASSFIQL
ITGSVPIFPP MFRELCAHIA KVVNQVWPEA KFTALGAFIF LRFISPAVVS PETIDIEVPK
DPTLRRGLML IAKIVQNLAN NIFFGKEPHM VVLNDFLKEN IVRVTRFLTE INKSPSETQE
DEPEEWLDTS YDDTDTIVLH RFFHRHADKI GKELLSPPKL PSEKLTQEAE ACITSGKRAW
EALCTVLVDM GQPLESPKVS TATSAEHQDY LELMSRYKNK DTTSVQDLFV EVRLPEDEDD
ASVFILFANK VDVEILDIEL LLYYIFKTLT SPRYETQSYD IIFDFTSFAS TSQIPAQWLK
FAQEVIPIDI RERFRTSRIL TPNALALKYL RRMYNLASGA AFSRTYSAHC TVEELLEQYP
DGTEMPPLQY AEDLEREPCE VFRDVTMRHT HPMRIPVTLN VAMSHLRITT TKAHQISNTL
SCKATEIIPL ADINDVYNVS TGKDSYEFII RKVRHGVTSY FSSPARDAIV KLIRGAKGNM
RAVHLPGAER FTRLSNVVTT LLHVGMVNVC SEDEEPRSAA LELLSAVCTY LDYEGKPVVP
SKSFFICGNS GPFLTQLSEG LATFAPQLTL DFVTEVASGI SKAPGSQRVT CLQYMSPWLR
NLGHFTDQAD KLFDQSGARF RDCVRVLIDL TLSEHELTNL VHKYVWTEIG RQDSITVNAV
LDECMRAAVD GGIGSPACDM IAHAMGALSS INVRGRIISR IRKVIGKTSM KPTKNLADNA
HWNEIACLMQ LLVVATSHAK SASHSQLYIP ETFHLVVLTA ATGQTSVRTC VYGTVVNMLQ
SLYSHRSTES STGPDIQVLL EECSQPETLR LFGLVRPTSS GDYVSWDPTT DKLSIDTLES
LTRFLARTME AISGNRGLLN VWRARWMSLV TSSAFQLSPS IQTRAFSTLG ILATSDVDDD
LLYQMLVAFK TALAQSNEND TVAVVSMLRC MRNVTPALPK QSRYLSQLFW LAVALLQSSL
LALYVEAINL LRVALETMDQ QDMFNEKGMA AVLLEGREPL EEIACQLDQL LGLSFESSFS
FSLASIIFKG VRHSGLKDAT EATLRTLLRI TVRACRDVEH ADDGPGAPVC QEGLGYFLAL
LPMSTAAGSF KQLLEDADVD PGWLSEEVLA FEADDDEVSR IPFGLVGMAD GHAILFVTSF
ISAMLVTAQG GDTESEILYS ILSDVADAFP DIIALTYDTL QDRIKDIFAN SSSPVILRAV
SNIFRVAMHE ADRAALARSS ASTLSTVEEG AVHGPSRRHL HALEDQGMQG LANSFQFLPP
NRGHATKMIN WISELVTKII E
//
