GenomeNet

Database: UniProt
Entry: M2S9R0_9SPHN
LinkDB: M2S9R0_9SPHN
Original site: M2S9R0_9SPHN 
ID   M2S9R0_9SPHN            Unreviewed;       395 AA.
AC   M2S9R0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   RecName: Full=Pseudouridine synthase {ECO:0000256|RuleBase:RU362028};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362028};
GN   ORFNames=C725_2406 {ECO:0000313|EMBL:EMD82120.1};
OS   Pacificimonas flava.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingosinicellaceae; Pacificimonas.
OX   NCBI_TaxID=1234595 {ECO:0000313|EMBL:EMD82120.1, ECO:0000313|Proteomes:UP000011717};
RN   [1] {ECO:0000313|EMBL:EMD82120.1, ECO:0000313|Proteomes:UP000011717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2015 {ECO:0000313|EMBL:EMD82120.1,
RC   ECO:0000313|Proteomes:UP000011717};
RX   PubMed=23661488;
RA   Tang K., Liu K., Li S., Jiao N.;
RT   "Draft Genome Sequence of Strain JLT2015T, Belonging to the Family
RT   Sphingomonadaceae of the Alphaproteobacteria.";
RL   Genome Announc. 1:E00226-13(2013).
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil.
CC       {ECO:0000256|RuleBase:RU362028}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC         Evidence={ECO:0000256|RuleBase:RU362028};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(1911/1915/1917) in 23S rRNA =
CC         pseudouridine(1911/1915/1917) in 23S rRNA; Xref=Rhea:RHEA:42524,
CC         Rhea:RHEA-COMP:10097, Rhea:RHEA-COMP:10098, ChEBI:CHEBI:65314,
CC         ChEBI:CHEBI:65315; EC=5.4.99.23;
CC         Evidence={ECO:0000256|ARBA:ARBA00036882};
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876, ECO:0000256|RuleBase:RU362028}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMD82120.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMRV01000009; EMD82120.1; -; Genomic_DNA.
DR   RefSeq; WP_008603232.1; NZ_JACHGC010000003.1.
DR   AlphaFoldDB; M2S9R0; -.
DR   PATRIC; fig|1234595.3.peg.2408; -.
DR   OrthoDB; 9807829at2; -.
DR   Proteomes; UP000011717; Unassembled WGS sequence.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   NCBIfam; TIGR00005; rluA_subfam; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR21600:SF44; RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362028};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011717};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          106..256
FT                   /note="Pseudouridine synthase RsuA/RluA-like"
FT                   /evidence="ECO:0000259|Pfam:PF00849"
FT   REGION          342..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        149
FT                   /evidence="ECO:0000256|PIRSR:PIRSR606225-1"
SQ   SEQUENCE   395 AA;  43506 MW;  388BD995F749CFB4 CRC64;
     MSGHEDVRQF TVAPDDDDIR LDRWFKRHMP EASFTIVSKW ARTGQLRVDG SRAKPGDRIR
     AGQVLRVPPL EAERVSPMAE KRERRPLTED QIEFARSLVI HKDAHAIVIN KPPGLATQGG
     TGQKAHVDGL LDALKFDRDE RPKLVHRLDK DTSGVLLLAR TARAAAHFSK AFSGRTARKI
     YWAIVMGVPE IPDGRIDLPL AKQPGTGGEK MHVDQEGGQR AASRYRRIDR AANRAAWLEL
     QPLTGRTHQL RVHMEAIGHP IVGDGKYGGK DSFLTGGISR KLHLHARRLK IEKPDGGVLN
     VIAEPPEHFA ASLTNLGFDP VEGDLPLEEE LDDPGFKARL AKNKSRDIRR AKRDEHAARR
     GAARKSTGRG APPAKPSGKK GGRPGGRSGG GTRRK
//
DBGET integrated database retrieval system