ID M2SH90_COCSN Unreviewed; 2869 AA.
AC M2SH90;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
DE Flags: Fragment;
GN ORFNames=COCSADRAFT_54465 {ECO:0000313|EMBL:EMD61780.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD61780.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD61780.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB445647; EMD61780.1; -; Genomic_DNA.
DR RefSeq; XP_007702174.1; XM_007703984.1.
DR STRING; 665912.M2SH90; -.
DR GeneID; 19140308; -.
DR KEGG; bsc:COCSADRAFT_54465; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_7_1; -.
DR OMA; AFEGTHY; -.
DR OrthoDB; 2190653at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016934}.
FT DOMAIN 204..280
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1702..1778
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2778..2854
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMD61780.1"
FT NON_TER 2869
FT /evidence="ECO:0000313|EMBL:EMD61780.1"
SQ SEQUENCE 2869 AA; 318740 MW; DCBB61D70F0FB45C CRC64;
ILEGPALGRE YIDEPEKTAA SFIEAPAWRA SFGQNNRSKR LYKTGDLARY KKDGSVELMG
RKDNQVKLRG QRIEIGEIEH QVRQAKCGVK QAVAELIRPH DCEDDLLACF IVLDDDLDNE
MNENDDENTK YTTKTQKVVQ QVQEKLDQFL PQYMVPSAFI RVPQLPLTWS GKIDRKKIRE
MGASLSTQEL LAEMRTQSQG PKRQPTTAIE QALQQLWAQV LGIDMDTIGL DDSFFRLGGD
SIAAMKLVAE ARRLGMKLTV ADVFRSPKLC QLTTVVATTS VTDSPTTIPR VHHTGPALQS
FAQGRLWFLE ELYPGLNWYS MPLMVRMKGP LQLEALKSAL LAVESRHETL RTTFDTINGV
GLQFVEPFCS KDISVIEMPA GDKQRLTDAL QRDQATPFDL RLEPGWRAAI YRIGEDEHVL
SVVMHHIILD GWSMDVVTRE LAAFYSAATQ GRDPLVQVQP LPIQYRDFSL WQREQAQVEN
NQKQLDYWVR QLQGNRPAEL PCDKPRPAAL SGQAGVRSIQ IRGSLYDDLQ RFCKLHGMTY
FVVLLAAFRA AHFRLTGQGD ATIGTPNANW ERWEVKDMVG FFVNLQCLRT SVGEGTFKSL
VDQVHDVVVA SHANADVPFE SIVSKLKNDR DLSRHPFFQI VFAVHSQQDF GQLKLEGLET
EIVPMPANSR FDMEFHFYQQ ADGLQGNMQF STDLYAPETI DNMLSIFHVV LETCLKEPET
VVASLPMLSD AHFCKLDKMG LIQVEETAYP RDSSIVDLFR QQAFICASKV AVQDASAKMT
YAQLDEASDT LAWWLAKRAL APETLVGVLA NRSCEAIIAF LGILKANLAY LPLDSKTPTK
RIEAILSSLP GYTILLTGAD IPNTNIQLSK VEVVGIREAL TEAMDDFISQ QSVTTIEGPS
STSLAYVMFT SGSTGQPKGV MVEHRGIVRL VRDNNLVQYL PTSPVMAHMA NLAFDASIWE
IYAPLLHGGT IVCIGSMAVL DPEVVLQIFR LHHVQSAFMT PTLMGSYAKQ LPAIFTGIEM
LCVGGEALQP HHIQSIENVF TGKLVNSYGP TENSAWSTLF LVAKKERLLN GVPIGRALSN
SGAYVMDSKL TIVPLGVVGE LVVTGDGVAR GYTDPSRDID RFVSVTISGQ TVKAYRTGDY
VRWRPTDGEL EFFGRMDGQV KIRGNRVELS EIEHVLYSHK SVSEAVVVVQ QQGEEARLAG
FVTVNESTTM ANAQHDNSGE SHHVDAWETK FESELYSPIS VVRPESIGRD FVGWTTMFDG
REIDKGEMNE WLDDTIHTIL EIHRPDHVLE IGSGTGMILF NLGNGLRSYV GLEPSQKAIN
FITESVKYMP MLSGKVQMHK ATAADVGHLK TPIIASLVIL NSVVQYFPSL EYLFKTVQQL
LKIDTVRTIY FGDIRSYALH REFLTTRSLR IAGGKATKAD IQRMVNDMER VERELLVDPG
FFTALPDYFP GLVEHIEILP KKMRGTNEPS CYRYAAVVHV RETNQQTRDI RSLGDGEWID
FVERRLERQS LLQLLRDLPV SATIAVSNIP YSKTILDRCL IDALDGTEAE TFDHKNWLSE
VHQRAQRFAS LSPIDLVELA QEANCQVEIS WNRQFSQRGG LDVIFHRYPP QKEENRIMFR
FPTDHSDRPW HSLGSKPLQH KFLQRIPQEL LEIAEGHLPA YMIPQTITVL DAMPMNQNGK
IDRKALAERT EIQNSHREST QQLMSAGEKM MQQLWAQVLG IDADTIGLDD SFFRLGGDSM
AAMKLVAKAR KQGIQLTVAS IFDSPKLTNL VALVHREAPT TAQYIEPFSL LNLDSDAEKA
QIQDEVAASC GLDKGLVEDI YPCSPLQEGL MSLTSKRAGD YIMQSILELH GDIDEGAFRA
AWEQVVLSSA VLRTRIVYHS KLGLLQVVVA EGIQWSESDD LQAYIAEDKS ATMGIGNVLA
RYAIVKEHNS GKRWFVWTVH HVLYDGWSLP RIINAVERAY KGAAVEKEAG FNAFIQHLSQ
QDQEEAARYW QATLSGCDAM PFPSLPPTVQ QPVPDTMLEY TCPPLPKTVS DTTKSTLIHA
AWAIVASSQT NSDDVIFGVT VTGRNAPVAG IEAMLGPTIA TVPMRLRFPR DLTVSAFLKR
VQKQMIETIP YEQMGLQRIA KMSPDAQHAC NFQTLLVVQP ASDELGTNEA LGTWKNESVR
LNFTTYALAL QCTLADSGIH IMASFDSRAV DPWQMEKTMG QFSSVMRQLA DIDAKKTVAE
INVLSPKDRE QLWVRNGTVP PAVERCVHDL FAEQARAQPN APAIYAWDGE LTYGELDELS
SRLADYLVSL DLEVEGFVPF CFEKSLWTVV AMLAVLKAGA AFVPLDPEHP ANRHQEIFQQ
TKARIVLVSE QHSTLHQYGD RTVVVVSKAS IAGLPSQAVR QRKAHRKVQP GNAAYVIFTS
GSTGKPKGVV VDHRATTTSC LAHGAAILRN RDSRVLQLAA YTFDMCLAEI ITTVLLGGCV
CVPSENDKRN NLVKTIAEMR VTSAILTPTV AQLLDPNAIP SLRTLVLGGE AVSMSEWNRW
EGHVDVINGY GPAECTIICA TYHSGDGFQS GTIGKSVGSI SWIVDPADHN RLSPPGSVGE
LLVEGPILAR GYLGDAEKTA EVFINDPAWL LEGCDQYPGR HSRLYKTGDL VRYGPDGNLV
FVGRKDGQVK VRGQRVELGE IEHHVHECMP AAEQMAVEVI LPGNEKAKAA VAVFLQLREH
DAAVDGSPAR VFFPVEVDSQ LSERLPSYMV PAVYFAVHQL PMTTSGKVDR GRLREIGASF
TAQELADLRT HSQGPKRQPT TDKERMLQQL WAQVLNVEAA AIGLDDSFFR LGGDSITGMK
LVTEARKHDI HLSLAGVFKH PKLINLAAWA AKDAQVTSQG IAPFSLLNS
//
