ID M2SRM8_COCSN Unreviewed; 938 AA.
AC M2SRM8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=UDP-N-acetylglucosamine diphosphorylase {ECO:0000256|ARBA:ARBA00012457};
DE EC=2.7.7.23 {ECO:0000256|ARBA:ARBA00012457};
GN ORFNames=COCSADRAFT_203477 {ECO:0000313|EMBL:EMD59741.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD59741.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD59741.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP =
CC diphosphate + UDP-N-acetyl-alpha-D-glucosamine; Xref=Rhea:RHEA:13509,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:46398,
CC ChEBI:CHEBI:57705, ChEBI:CHEBI:57776; EC=2.7.7.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001851};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-
CC acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005208}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB445652; EMD59741.1; -; Genomic_DNA.
DR RefSeq; XP_007704726.1; XM_007706536.1.
DR AlphaFoldDB; M2SRM8; -.
DR STRING; 665912.M2SRM8; -.
DR GeneID; 19134260; -.
DR KEGG; bsc:COCSADRAFT_203477; -.
DR eggNOG; KOG2388; Eukaryota.
DR HOGENOM; CLU_011580_0_0_1; -.
DR OMA; HAYIAHE; -.
DR OrthoDB; 33243at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0050032; F:L-rhamnonate dehydratase activity; IEA:InterPro.
DR GO; GO:0070569; F:uridylyltransferase activity; IEA:InterPro.
DR CDD; cd03327; MR_like_2; 1.
DR CDD; cd04193; UDPGlcNAc_PPase; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR Gene3D; 3.30.390.10; Enolase-like, N-terminal domain; 1.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR029065; Enolase_C-like.
DR InterPro; IPR023444; L-Rhamnon_dehydrat.
DR InterPro; IPR013342; Mandelate_racemase_C.
DR InterPro; IPR013341; Mandelate_racemase_N_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR039741; UDP-sugar_pyrophosphorylase.
DR InterPro; IPR002618; UDPGP_fam.
DR PANTHER; PTHR11952:SF2; LD24639P; 1.
DR PANTHER; PTHR11952; UDP- GLUCOSE PYROPHOSPHORYLASE; 1.
DR Pfam; PF13378; MR_MLE_C; 1.
DR Pfam; PF02746; MR_MLE_N; 1.
DR Pfam; PF01704; UDPGP; 1.
DR SFLD; SFLDS00001; Enolase; 1.
DR SFLD; SFLDF00006; rhamnonate_dehydratase; 1.
DR SMART; SM00922; MR_MLE; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016934};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 176..274
FT /note="Mandelate racemase/muconate lactonizing enzyme C-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00922"
SQ SEQUENCE 938 AA; 103527 MW; 4BE218B97C9A2771 CRC64;
MASSPTSGAS RSFPTIKHVR TFVTQGPGSG GDYHNVAGGH WLIDSKISTP MSQYEQYRKS
RTSWGINVLG SFCVEIEASD GTKGFATGFG GPPACWLVAE HFERFLIGQD PRDTNHIFEQ
MYRASMFYGR KGLPVAVISV IDLAIWDLLG HIRNEPVYKM LGGATRERLN FYCTGPEPAA
AKEMGFFGAK VPLPYGPGEG VEGLKKNVEF LTKHRESVGP DFPLMVDCYM SLNVPYTIEV
VKATEHLNLN WWEECLSPDD SDGFEQIKRA HPRMKFTTGE HEYSRYGFRK LIEGRNLDIL
QPDVMWVGGM TELIKISAMA AAYDIPVVPH ASGPYSYHFV VSQANSPFQE YLANSPDGKS
VLPVFGNLFT NEPIPTKGYL DVKTLDRPGF GLELNPHAGL IDATRILNPA PQKALKPAEP
EKPAETNGTI KDTVNSALEK LHIGGTAQGT PAKEPSEAEF NELKAKYQKA GQDQVFSFYD
KLSTSEKASL YEQLSNFNPE YINEITERAL HPAQTEATEN KLEPLPENAT SSVLDSSQDN
LDQWYNNGLE FIANNQVAVV LMAGGQGTRL GSSAPKGCFD IGLPSQKSLF QLQGERIRKA
EMLAAKKHGK ENVTIPWYVM TSGPTRGPTA EFFEKHNYFG LKKENVVIFE QGVLPCISNE
GKILLESKSK VAVAPDGNGG LYQALIQSGV VADMGKRGIK HIHAYCVDNC LVKVADPVFI
GFSASKNVDI ATKVVRKRNA KESVGLILQK NGKPDVVEYS EISTEDAEAK DPKDSELLKF
RAANIVNHYY SYSFLESIPA WAKKLPHHVA RKKIPYVNTE TGETIKPEKP NGIKLEQFVF
DCFPFLTLDK FACMEVKRED EFSPLKNARG TGEDDPDTSK QDIMMQGKKW VQAAGATVVS
EDPKEGIEVS PLISYGGEGL DFLKTRTIKA PAVIESED
//