ID M2T736_COCSN Unreviewed; 1235 AA.
AC M2T736;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Fork-head domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCSADRAFT_218547 {ECO:0000313|EMBL:EMD70235.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD70235.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD70235.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; KB445637; EMD70235.1; -; Genomic_DNA.
DR RefSeq; XP_007695337.1; XM_007697147.1.
DR AlphaFoldDB; M2T736; -.
DR STRING; 665912.M2T736; -.
DR GeneID; 19134544; -.
DR KEGG; bsc:COCSADRAFT_218547; -.
DR eggNOG; KOG2294; Eukaryota.
DR HOGENOM; CLU_005469_0_0_1; -.
DR OMA; YMHTYQI; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0060962; P:regulation of ribosomal protein gene transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00059; FH_FOX; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR045178; Fhl1/FHA1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR21712:SF29; PRE-RRNA-PROCESSING PROTEIN FHL1; 1.
DR PANTHER; PTHR21712; UNCHARACTERIZED; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000016934}.
FT DOMAIN 314..347
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 707..795
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 707..795
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..611
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..849
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..967
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1200
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1235 AA; 133701 MW; 0AF409B37E5AA485 CRC64;
MAVAPSSEQL HHVVAQDDSP APGHPSIHHQ RAPEMASTTT TTTADAPPAL PAVSAEDAPA
HPGPMDTIDN MNTANTLSHP QISPLADPIN LAQSADMNGD MNGDMAATTA VAAPLPMDVA
TAASAFPAMD PFMPPTTNER LTAFARLRFD DGSYYMHTYQ ITLGRNIHLA HRDMKRLIKA
EALHAKGHTK AAEEYLNGKK DRKKKKRERR GARSVISEKG GIVNVPIESM PMEFQQRRQS
NASHSLSSNS HPAGEAAEEN PAERAPQNML MQTFPEVPAQ FDGHVPEDPN DCPFVPIHPQ
QIMAKTGSLG PKGISREHAK IFFDFDAGHF CIHVLGNNGL HHEGDFYPKG ETVPLDHGDH
LLIGAVNIHF YLPDVALTEQ QRHRQESGSR PMSFSFENGN GQLESDEHIS SESEDQQSVN
PRHVYYHHPV SDSDDDDGLA DEEMDDYEEP LPKPRQKTNL KGKTKESARE SAKEPKAHKE
RKESREQKDT KDKESIPSKE TKEPKEPKEP KEKGKAPAKT PAKTTVKDEA PAEEPVKDIP
VATKSEQPSK PPPNDSPPLL RKPHEGELEA GDIDGLITEE MAIQHNLPRN LIGHVVEKRK
GPGRPPKDGI MSKRQRSQLI KQAKDIERAR AAGIDPADIP IPTIKPKAPK RKESNAGDGD
DDGVVESTEH GDGTLSGLQK QVKPMRPPRT PSPEMRIEDY TEEQLQRPTA NYVVLIHEAI
SSSPTGQMNL QSIYTYIERK YPWYKFKTTT SGWQSSVRHN LGQHDAFMKG DKEGKGYLWR
INPEVSIEKE RRKRQASPPL NHAPRPQYYQ PPPNGYQPYP QPGYPYHPGM PHAMPQAPPR
LPPSLAQPRL PPSMARGEGN AAASNGPQNA PHPSPYASPW AGGNTGASPP AANPPRPYPS
PHTQTSTANS AAGSSGQYGV LFPTAAPQQS PYSGPSAPSP YGGPYATAGA SPYGPAPPRP
YPPYPAAGQQ ANAPTASSAQ RNASPYGPPL TQAPAHQSSS NEGSAPHPSG RYPIGVHPDL
IRQLEAYRLV YLEKRPGPDE QKKVDNAIRA CVDRTVPEAS LTEPERKLLE SICGVESINK
HVKRNVAVKP EDTPVTVPAT AAGTAAAIAA DAAANTLAQH QQQQQKLAEQ PPSETKSASP
ALPHENSEPQ KFTPNMTGAS PAPPATVPPS TSTPAPPAAP SHRPSVEPIT PVPGSPAVPN
GTPLRRPLAE STADSLARAE ESTKAEPSEE PEKTE
//
