ID M2TGA1_COCSN Unreviewed; 573 AA.
AC M2TGA1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Nuclear fusion protein KAR5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCSADRAFT_81426 {ECO:0000313|EMBL:EMD68271.1};
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912 {ECO:0000313|EMBL:EMD68271.1, ECO:0000313|Proteomes:UP000016934};
RN [1] {ECO:0000313|EMBL:EMD68271.1, ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016934}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652 {ECO:0000313|Proteomes:UP000016934};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU368082}.
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DR EMBL; KB445638; EMD68271.1; -; Genomic_DNA.
DR RefSeq; XP_007695924.1; XM_007697734.1.
DR AlphaFoldDB; M2TGA1; -.
DR STRING; 665912.M2TGA1; -.
DR GeneID; 19140831; -.
DR KEGG; bsc:COCSADRAFT_81426; -.
DR eggNOG; ENOG502QVCQ; Eukaryota.
DR HOGENOM; CLU_473268_0_0_1; -.
DR OMA; ECKLLEH; -.
DR OrthoDB; 1940841at2759; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368082};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000016934};
KW Signal {ECO:0000256|RuleBase:RU368082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368082}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT TRANSMEM 423..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT TRANSMEM 448..471
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT TRANSMEM 503..527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT COILED 248..275
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 573 AA; 64573 MW; 54BD963A1A11BF11 CRC64;
MTIQQQKQLL SIWGGVTFAK LLILGIFFLP KALAHYHSPL ADAAPTINVN SLFQHTTSRN
QKVITQALGI VSSMQNAPTC THMAASHLMN ECKLLEHAPE FTKSRPEAYL DKVKIEYAAK
LAVCELLSTQ PVNSVAPPHC NILVPAAKHC DKGGSWWLAR PAMVSEDKQC YPDFKEYQYM
QCLKSLQSTP QYWTSFSNAR QNAIVMCQAS RDAIERENHL EIFKNLTKVV GGVTENMHKT
TAEYESLIHE QRKYAEEARN THQELRDDIQ AVRITAVATV EVIDNKFNTF MKSSISNLIA
ALATSQSKEI DQIHEKMQEF LQDLMLESSQ LAKYFTDQLQ QYHQGALSSL QSNHKAQVRS
YEVLSNYMGV TQDTINRTNQ AADRSLYKVD SIAQRLDIFE SQTKHIAEGF AFLSAMPTLV
KSLVHGLVAT AGSIFTFFVL FKLNMRLAIY TVGACSWTFL FYTSGTLYWL ASPSSHTHDT
EAFNPLAIFD NMSSWQKVTG MLLLLWLSAY PICRLNIYLG GFVTMAFRRL AGLIWLYEYS
NESGTAYLPC IEIPAPVPNV PPKDSIRATR QLN
//