ID M2TLZ0_9SPHN Unreviewed; 685 AA.
AC M2TLZ0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Enoyl-CoA hydratase {ECO:0000313|EMBL:EMD82751.1};
GN ORFNames=C725_1791 {ECO:0000313|EMBL:EMD82751.1};
OS Pacificimonas flava.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingosinicellaceae; Pacificimonas.
OX NCBI_TaxID=1234595 {ECO:0000313|EMBL:EMD82751.1, ECO:0000313|Proteomes:UP000011717};
RN [1] {ECO:0000313|EMBL:EMD82751.1, ECO:0000313|Proteomes:UP000011717}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2015 {ECO:0000313|EMBL:EMD82751.1,
RC ECO:0000313|Proteomes:UP000011717};
RX PubMed=23661488;
RA Tang K., Liu K., Li S., Jiao N.;
RT "Draft Genome Sequence of Strain JLT2015T, Belonging to the Family
RT Sphingomonadaceae of the Alphaproteobacteria.";
RL Genome Announc. 1:E00226-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMD82751.1}.
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DR EMBL; AMRV01000005; EMD82751.1; -; Genomic_DNA.
DR RefSeq; WP_008602014.1; NZ_JACHGC010000001.1.
DR AlphaFoldDB; M2TLZ0; -.
DR PATRIC; fig|1234595.3.peg.1794; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000011717; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000011717}.
FT DOMAIN 298..474
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 479..563
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 600..681
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 685 AA; 74362 MW; 2287A1AB4A5BD8AB CRC64;
MTSPVRTERH DDVLVVISDN PPVNALGAAV RQGLKEGVEA GLADDSVKAI VIRCDGRTFH
AGADITEFGK PPQGPSLPET LDAMEASAKP IVAAIHGTAL GGGLEVALAC HYRVAVPSAK
LGLPEVNLGL LPGAGGTQRL PRVVGVEKAL DMIVFGRPIG AGEAEKIGLV DTLAGEDSLE
ADAIAFAREK AKADSHPATS RRTDRLPDAA HIGQIFDDFK AKNGRKMRGF DAPAACMRCV
RAAAELPYVE GVKVEREEFM KLMQGDQSKA QRHLFFAERQ AAKIDDVPKD TPLIPIRKVG
IIGAGTMGGG IAMNFLSAGI PVTMLEMKQE ALDRGTGVMG KNYEGNVKRG RMSEEKAKAA
MDLLSTTLDY ADLADCDLVI EAVFESMDVK KDVFGKLDAH VKDGAILASN TSYLNVDEIA
QATKRPGYVV GMHFFSPANV MKLLEVVRGA ETRPDVLATV MALSKKIGKV AVVAGVCHGF
IGNRMLSPRQ REANKLIMEG ATPWQIDKVH QEFGMPMGPF QMSDLAGLDI GWHRDTNRIE
SLRDELCAMD RRGQKTGAGF YDYDENRRGT PSDTVEALIR KWAEKEGTPQ REISDEEIRE
RTLYPMVNEG ALILEEGMAQ RASDIDVVWI YGYGWPRYRG GPMFWADLEG ADTILAGLEK
HQDKMPDLKI SQLLKDKAAK GETFN
//