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Database: UniProt
Entry: M2TLZ0_9SPHN
LinkDB: M2TLZ0_9SPHN
Original site: M2TLZ0_9SPHN 
ID   M2TLZ0_9SPHN            Unreviewed;       685 AA.
AC   M2TLZ0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Enoyl-CoA hydratase {ECO:0000313|EMBL:EMD82751.1};
GN   ORFNames=C725_1791 {ECO:0000313|EMBL:EMD82751.1};
OS   Pacificimonas flava.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingosinicellaceae; Pacificimonas.
OX   NCBI_TaxID=1234595 {ECO:0000313|EMBL:EMD82751.1, ECO:0000313|Proteomes:UP000011717};
RN   [1] {ECO:0000313|EMBL:EMD82751.1, ECO:0000313|Proteomes:UP000011717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2015 {ECO:0000313|EMBL:EMD82751.1,
RC   ECO:0000313|Proteomes:UP000011717};
RX   PubMed=23661488;
RA   Tang K., Liu K., Li S., Jiao N.;
RT   "Draft Genome Sequence of Strain JLT2015T, Belonging to the Family
RT   Sphingomonadaceae of the Alphaproteobacteria.";
RL   Genome Announc. 1:E00226-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the enoyl-CoA
CC       hydratase/isomerase family. {ECO:0000256|ARBA:ARBA00008750}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMD82751.1}.
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DR   EMBL; AMRV01000005; EMD82751.1; -; Genomic_DNA.
DR   RefSeq; WP_008602014.1; NZ_JACHGC010000001.1.
DR   AlphaFoldDB; M2TLZ0; -.
DR   PATRIC; fig|1234595.3.peg.1794; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000011717; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011717}.
FT   DOMAIN          298..474
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          479..563
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          600..681
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   685 AA;  74362 MW;  2287A1AB4A5BD8AB CRC64;
     MTSPVRTERH DDVLVVISDN PPVNALGAAV RQGLKEGVEA GLADDSVKAI VIRCDGRTFH
     AGADITEFGK PPQGPSLPET LDAMEASAKP IVAAIHGTAL GGGLEVALAC HYRVAVPSAK
     LGLPEVNLGL LPGAGGTQRL PRVVGVEKAL DMIVFGRPIG AGEAEKIGLV DTLAGEDSLE
     ADAIAFAREK AKADSHPATS RRTDRLPDAA HIGQIFDDFK AKNGRKMRGF DAPAACMRCV
     RAAAELPYVE GVKVEREEFM KLMQGDQSKA QRHLFFAERQ AAKIDDVPKD TPLIPIRKVG
     IIGAGTMGGG IAMNFLSAGI PVTMLEMKQE ALDRGTGVMG KNYEGNVKRG RMSEEKAKAA
     MDLLSTTLDY ADLADCDLVI EAVFESMDVK KDVFGKLDAH VKDGAILASN TSYLNVDEIA
     QATKRPGYVV GMHFFSPANV MKLLEVVRGA ETRPDVLATV MALSKKIGKV AVVAGVCHGF
     IGNRMLSPRQ REANKLIMEG ATPWQIDKVH QEFGMPMGPF QMSDLAGLDI GWHRDTNRIE
     SLRDELCAMD RRGQKTGAGF YDYDENRRGT PSDTVEALIR KWAEKEGTPQ REISDEEIRE
     RTLYPMVNEG ALILEEGMAQ RASDIDVVWI YGYGWPRYRG GPMFWADLEG ADTILAGLEK
     HQDKMPDLKI SQLLKDKAAK GETFN
//
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