ID M2TU03_COCH5 Unreviewed; 913 AA.
AC M2TU03;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 13-SEP-2023, entry version 37.
DE RecName: Full=SET domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=COCHEDRAFT_1039758 {ECO:0000313|EMBL:EMD90014.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD90014.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD90014.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
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DR EMBL; KB445578; EMD90014.1; -; Genomic_DNA.
DR AlphaFoldDB; M2TU03; -.
DR STRING; 701091.M2TU03; -.
DR eggNOG; KOG1079; Eukaryota.
DR HOGENOM; CLU_005798_0_0_1; -.
DR OMA; VCHQHNC; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 450..559
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 569..691
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 374..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 740..767
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMD90014.1"
FT NON_TER 913
FT /evidence="ECO:0000313|EMBL:EMD90014.1"
SQ SEQUENCE 913 AA; 103317 MW; 668E24580129ACC0 CRC64;
TPPVKDVTPN VNSVWSSHVH DLAATRSAID ECLKRHIAER NEAHAKLTWI KLRHQRTCQE
RDLRARRKQK FATQPTLPEE FIQHTSPFAD IPVVQMPFDR SWASKGLPDM AQEVFVKAKP
RDTVFRSGLS AHTTKFRSEA VVIPPFKEYV SLRNNILADN ESKLLATPYF EDEDYESRLA
LLDALPTIYE LTHDEKGPID LRKEQCRFYR IAIEAFLGEI GVTWNEVLYW LLASDDVIKQ
INTGMSGSED FSSILLERSQ YSIEEFERDE ELKETTLFDR DDEKWQDFIK QLERPSAMTL
RLAAIACSAV LHECEFSIWY LAQQSDIVQN NILRKTLTGK NPVQSSYRQI WCRVCHQHNC
LLHGELRQVP EDSWMTESDE DDDEFQSSRR NSGSTLDEDS SPLPAHFDDD SDIEKVINYK
LPANADAFNA YPESEMIASR GAKPPPGKFN AHWWLQRDLV QHWEKRKPFF PCNHEGSCED
ARCRCYREGI TCEKTCKCSQ SCNRRFPGCG CLVIPGKRVC DSDKCLCVKF NRECDAELCG
SCGATEILDP VNRYNEDVVA RNCFNVAIQR GVPRKTLLGH SEVHGFGLYM GEDIEKGEYI
GEYTGEAISV NEGNRRLTIY DYQKTMYLFR LNSKQEVDAT YMGNKLRFIN NADDKYTNCA
PRNLLCNTVF RIALFATTNI KAGTELYFNY NYPKEKTAQF KQPNGKVVAV KETKPKVKRV
DAGSKTSQPV VERDRSRILA ATAKARAAKA AKRAAMLEEE ARLALAKSLP GPFRARKTAT
GTPSVKRASK LRDSLCRNES TGSDTGLDVE VSDGEMSVAG ASQETTTSQY VEDTDEDGEF
TTGDSQENGY ENVRRSARHG SAVGHRRPGR PRKRGSDVAP AMATERRSGN LGGARPGAGR
KRKRPVILNS DDE
//
