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Database: UniProt
Entry: M2TW03_COCH5
LinkDB: M2TW03_COCH5
Original site: M2TW03_COCH5 
ID   M2TW03_COCH5            Unreviewed;      1115 AA.
AC   M2TW03;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   05-JUN-2019, entry version 39.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=COCHEDRAFT_1179801 {ECO:0000313|EMBL:EMD90709.1};
OS   Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O)
OS   (Southern corn leaf blight fungus) (Bipolaris maydis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
OC   Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD90709.1, ECO:0000313|Proteomes:UP000016936};
RN   [1] {ECO:0000313|EMBL:EMD90709.1, ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A.,
RA   Barry K.W., Condon B.J., Copeland A.C., Dhillon B., Glaser F.,
RA   Hesse C.N., Kosti I., LaButti K., Lindquist E.A., Lucas S.,
RA   Salamov A.A., Bradshaw R.E., Ciuffetti L., Hamelin R.C., Kema G.H.J.,
RA   Lawrence C., Scott J.A., Spatafora J.W., Turgeon B.G.,
RA   de Wit P.J.G.M., Zhong S., Goodwin S.B., Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in
RT   the genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2] {ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R.,
RA   Martin J., Schackwitz W., Grimwood J., MohdZainudin N., Xue C.,
RA   Wang R., Manning V.A., Dhillon B., Tu Z.J., Steffenson B.J.,
RA   Salamov A., Sun H., Lowry S., LaButti K., Han J., Copeland A.,
RA   Lindquist E., Barry K., Schmutz J., Baker S.E., Ciuffetti L.M.,
RA   Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector
RT   coding capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KB445578; EMD90709.1; -; Genomic_DNA.
DR   STRING; 5016.M2TW03; -.
DR   EnsemblFungi; EMD90709; EMD90709; COCHEDRAFT_1179801.
DR   Proteomes; UP000016936; Unassembled WGS sequence.
DR   GO; GO:0043625; C:delta DNA polymerase complex; IEA:EnsemblFungi.
DR   GO; GO:0000784; C:nuclear chromosome, telomeric region; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:1904161; P:DNA synthesis involved in UV-damage excision repair; IEA:EnsemblFungi.
DR   GO; GO:1903459; P:mitotic DNA replication lagging strand elongation; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016936};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      130    476       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      540    979       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1017   1091       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     64       Disordered. {ECO:0000256|MobiDB-lite:
FT                                M2TW03}.
FT   COILED       68     88       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     13     32       Polar. {ECO:0000256|MobiDB-lite:M2TW03}.
FT   COMPBIAS     48     64       Polar. {ECO:0000256|MobiDB-lite:M2TW03}.
SQ   SEQUENCE   1115 AA;  126656 MW;  49F52A9400CBC16B CRC64;
     MPGTVTRAPA KRALAETSNT RTNVQTSPRS TKKLKFQDGK NKSKAPGRMA NDSFNSSQPG
     PSQFEETLEK MTQDMETLQK ENTEKDQQWR RPPLPHEFSE LTNNLVFQQI EAEEGVLHGG
     KTTVKLFGVT ETGHSVLLHV TGFQHYFYVA APVNFQQADC EPYKIFLEAE CQKSFNQHSA
     VIASVKMCMR ENILRFQGNQ KSPYLKITVT DPKLINRVRM MVQKGNANYK RLWPAREDGI
     LTFDNIAYVL RFMIDTKVTG MCWVEAPAAK WKMINARDRH SNCQIEGQVH YEDLIAHQAE
     GEWAKIAPLR ILSFDIECAG RKGVFPEANV DPVIQIANVV TKYGDDKPFV RNVFCLDTVS
     PIVATQILSF QDEGDMLMKW RDFLDEVDPD VIIGYNTSNF DFPYLLDRAK HLKLQKFPYW
     SRLKTVQSKV ETSNFSSKQM GSRDTKTTNT NGRLQLDLLQ LVQRDHQLRS YTLNSVCAHF
     LKEQKEDVHH SMITELFNGD SNSRRRLAVY CLKDAYLPQR LLDKLMCLVN YTEMARATGV
     PFNYILSRGQ QVRFISQLFR KALEHQLVIP DLPNQGDNGD QYEGATVIEP KRGYYKEPVA
     TLDFASLYPS IMQAHNLCYT TWLDRQTVEK LKMKKDEDYI VTPNGDMFCT AKTRKGLLTE
     ILEELLSARK KAKKELAVET DPFKKAVLNG RQLAMKVTAN SVYGLTGATN GKLPCLAIAS
     STTSFGRQMI ERAKAEVEAK YNIANGYSHD AEVIYGDTDS VMVKFGTTEL AEAMKLGEEA
     AKYVTSKFLK PIKLEFEKVY FPYLLINKKR YAGLYWTNPN KWDKMDTKGI ETVRRDNCRL
     VQTVIETSLR MLLIDQDPEG AQEFVKETIA DLLQNKIDMS NLVITKALTK QEDKDGKGGY
     ANKQAHVELA ERMKKRDAGS APALGDRVAY VMVRAATGAK NFEKSEDPIY VLENNLPIDT
     RYYLDNQLAK PLGRIFEPIL GEKKAASLLT GEHTRSISVA APTMGGLMKF AKKTQTCMGC
     KKPLTAAHEK DGAVCENCRP RIPELYTKTL TKVSELEVRF SRLWTQCQRC QGSVHCEVIC
     ASRDCPIFYM RMKARKDVED AGKELVRFDK DAALW
//
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