ID M2U1W9_9SPHN Unreviewed; 1084 AA.
AC M2U1W9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN ORFNames=C725_2851 {ECO:0000313|EMBL:EMD81803.1};
OS Pacificimonas flava.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingosinicellaceae; Pacificimonas.
OX NCBI_TaxID=1234595 {ECO:0000313|EMBL:EMD81803.1, ECO:0000313|Proteomes:UP000011717};
RN [1] {ECO:0000313|EMBL:EMD81803.1, ECO:0000313|Proteomes:UP000011717}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JLT2015 {ECO:0000313|EMBL:EMD81803.1,
RC ECO:0000313|Proteomes:UP000011717};
RX PubMed=23661488;
RA Tang K., Liu K., Li S., Jiao N.;
RT "Draft Genome Sequence of Strain JLT2015T, Belonging to the Family
RT Sphingomonadaceae of the Alphaproteobacteria.";
RL Genome Announc. 1:E00226-13(2013).
CC -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC translesion synthesis (TLS). It is not the major replicative DNA
CC polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_01902};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01902}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC Rule:MF_01902}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMD81803.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMRV01000015; EMD81803.1; -; Genomic_DNA.
DR RefSeq; WP_008603815.1; NZ_JACHGC010000012.1.
DR AlphaFoldDB; M2U1W9; -.
DR PATRIC; fig|1234595.3.peg.2854; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000011717; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01902; DNApol_error_prone; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR023073; DnaE2.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01902};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_01902};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000011717};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_01902}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 1035..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 120649 MW; 2B758FCB82469917 CRC64;
MSGYVELHML SHFSFLRGAS SPEELFSAAA LLGYGALGLA DLGTVGGIVR AWEAQKVTGV
RLIAGARVDL VCGRQLLLYP TDRAAWSRLT RLLSVGKARG GKGACLLEWN DLETWSDGLI
AILVPRDPDT ANETALRDMA ALFGDRAYMA LSFLRRPDDA LRMHQLSEQA RAAGVRAVAT
GNVLYHAEEA RLLQDVVTAI REKCTVDELG FARELHADRA LKSQDEMARR FRNYPNALAA
TAEIADRCRF DLGELSYQYP HERVMEGRSA QEALQLLTEE AATRMFPGGV PDAYAKQIAH
ELRLIGELDY APYFLTVNAI VTESRRRGIL CQGRGSAANS CVCFVLGITS IDPIRHELLF
ERFVSGERRE PPDIDVDFEH ERREEIIQWI FETYGRTHAA LTAVVTRYRA RGAVRDVGKA
MGLPEDMTAS LAGLVWGWSA EGVSERHVAE LNLDVADRRL RLTLDLARKL IGVPRHSSQH
PGGFVLTHDR LDDLVPIEPA AMADRQIIEW DKDDIDALKF MKVDVLGLGM LGCMNRAFGL
LREAKSIDIG LADLQDEDAD TFAMIQKADT LGTFQIESRA QMSMLPRMKP KCFYDLAIQV
AIVRPGPIQG DMVHPYLRRR EGLERPEYPK PELRAVLEKT LGVPLFQEQA MKVAIVGAGF
TPAEADGLRR AMATFKMTGG VSHFSDKLIG GMVERGYPRE FAERTFHQLE GFGSYGFPES
HAASFAKIAY ASSWMKCHHP DVFCAALLNA QPMGFYAPAQ IVRDAREHGV EVRGPCVNAS
RWDCTLEPAQ GRWLTVRLGL RMIRGLANGH GAAIVAARGD VTYESVEDVW RRAGTPRAAI
ERLAEAGAFE EFGHDRRQGL WRVRGLGETP LPLFAAADRN ERGTDSNEPD VALRPLTDGR
EVIEDYRTLQ LSLRAHPLTF LRDELRQQKV VTCADLEHLR DGRWVEVAGI ILVRQKPGSA
KGVLFITIED ETGIANAILW PDRFEAQRRT VMSASMIGVR GRIQREGSVI HVIADRIIDY
TSRLHGIGDM DFAHRTGRGD GARHPGSPDR REAGWKPRDQ YWPPHEGGID PEDAAVRIKS
RNFR
//