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Database: UniProt
Entry: M2U1W9_9SPHN
LinkDB: M2U1W9_9SPHN
Original site: M2U1W9_9SPHN 
ID   M2U1W9_9SPHN            Unreviewed;      1084 AA.
AC   M2U1W9;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000256|ARBA:ARBA00017273, ECO:0000256|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|HAMAP-Rule:MF_01902};
GN   Name=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN   ORFNames=C725_2851 {ECO:0000313|EMBL:EMD81803.1};
OS   Pacificimonas flava.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingosinicellaceae; Pacificimonas.
OX   NCBI_TaxID=1234595 {ECO:0000313|EMBL:EMD81803.1, ECO:0000313|Proteomes:UP000011717};
RN   [1] {ECO:0000313|EMBL:EMD81803.1, ECO:0000313|Proteomes:UP000011717}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JLT2015 {ECO:0000313|EMBL:EMD81803.1,
RC   ECO:0000313|Proteomes:UP000011717};
RX   PubMed=23661488;
RA   Tang K., Liu K., Li S., Jiao N.;
RT   "Draft Genome Sequence of Strain JLT2015T, Belonging to the Family
RT   Sphingomonadaceae of the Alphaproteobacteria.";
RL   Genome Announc. 1:E00226-13(2013).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis and
CC       translesion synthesis (TLS). It is not the major replicative DNA
CC       polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC         Rule:MF_01902};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000256|ARBA:ARBA00007391, ECO:0000256|HAMAP-
CC       Rule:MF_01902}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMD81803.1}.
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DR   EMBL; AMRV01000015; EMD81803.1; -; Genomic_DNA.
DR   RefSeq; WP_008603815.1; NZ_JACHGC010000012.1.
DR   AlphaFoldDB; M2U1W9; -.
DR   PATRIC; fig|1234595.3.peg.2854; -.
DR   OrthoDB; 9803237at2; -.
DR   Proteomes; UP000011717; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd07434; PHP_PolIIIA_DnaE2; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR023073; DnaE2.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF4; ERROR-PRONE DNA POLYMERASE; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01902};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW   Rule:MF_01902};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|HAMAP-Rule:MF_01902};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW   Rule:MF_01902}; Reference proteome {ECO:0000313|Proteomes:UP000011717};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_01902}.
FT   DOMAIN          5..72
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
FT   REGION          1035..1084
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1084 AA;  120649 MW;  2B758FCB82469917 CRC64;
     MSGYVELHML SHFSFLRGAS SPEELFSAAA LLGYGALGLA DLGTVGGIVR AWEAQKVTGV
     RLIAGARVDL VCGRQLLLYP TDRAAWSRLT RLLSVGKARG GKGACLLEWN DLETWSDGLI
     AILVPRDPDT ANETALRDMA ALFGDRAYMA LSFLRRPDDA LRMHQLSEQA RAAGVRAVAT
     GNVLYHAEEA RLLQDVVTAI REKCTVDELG FARELHADRA LKSQDEMARR FRNYPNALAA
     TAEIADRCRF DLGELSYQYP HERVMEGRSA QEALQLLTEE AATRMFPGGV PDAYAKQIAH
     ELRLIGELDY APYFLTVNAI VTESRRRGIL CQGRGSAANS CVCFVLGITS IDPIRHELLF
     ERFVSGERRE PPDIDVDFEH ERREEIIQWI FETYGRTHAA LTAVVTRYRA RGAVRDVGKA
     MGLPEDMTAS LAGLVWGWSA EGVSERHVAE LNLDVADRRL RLTLDLARKL IGVPRHSSQH
     PGGFVLTHDR LDDLVPIEPA AMADRQIIEW DKDDIDALKF MKVDVLGLGM LGCMNRAFGL
     LREAKSIDIG LADLQDEDAD TFAMIQKADT LGTFQIESRA QMSMLPRMKP KCFYDLAIQV
     AIVRPGPIQG DMVHPYLRRR EGLERPEYPK PELRAVLEKT LGVPLFQEQA MKVAIVGAGF
     TPAEADGLRR AMATFKMTGG VSHFSDKLIG GMVERGYPRE FAERTFHQLE GFGSYGFPES
     HAASFAKIAY ASSWMKCHHP DVFCAALLNA QPMGFYAPAQ IVRDAREHGV EVRGPCVNAS
     RWDCTLEPAQ GRWLTVRLGL RMIRGLANGH GAAIVAARGD VTYESVEDVW RRAGTPRAAI
     ERLAEAGAFE EFGHDRRQGL WRVRGLGETP LPLFAAADRN ERGTDSNEPD VALRPLTDGR
     EVIEDYRTLQ LSLRAHPLTF LRDELRQQKV VTCADLEHLR DGRWVEVAGI ILVRQKPGSA
     KGVLFITIED ETGIANAILW PDRFEAQRRT VMSASMIGVR GRIQREGSVI HVIADRIIDY
     TSRLHGIGDM DFAHRTGRGD GARHPGSPDR REAGWKPRDQ YWPPHEGGID PEDAAVRIKS
     RNFR
//
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