ID M2U480_COCH5 Unreviewed; 983 AA.
AC M2U480;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=COCHEDRAFT_1170917 {ECO:0000313|EMBL:EMD93334.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD93334.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD93334.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|ARBA:ARBA00008842}.
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DR EMBL; KB445573; EMD93334.1; -; Genomic_DNA.
DR AlphaFoldDB; M2U480; -.
DR STRING; 701091.M2U480; -.
DR eggNOG; KOG1737; Eukaryota.
DR HOGENOM; CLU_007105_4_0_1; -.
DR OMA; SYFVRWV; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13289; PH_Osh3p_yeast; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036598; GOLD_dom_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF216; OXYSTEROL-BINDING PROTEIN HOMOLOG 3; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 216..310
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 65..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 107207 MW; AFB704113C485503 CRC64;
MAGMENIEVH SKSYLVRWVN VSSGHTISWS VQPHKKSLNF GIFKHPGNAT GSAAHLPSTA
TFEAGPGTPS LEPPVTRGRG ASTSRNDRTV VLEKLSAIGL KQVHWHGKCE ADTVSMGTYD
IPPGEGGMYG LVFDNTFSKT VSKTATFVLM TYPTNAAPKS GHHMHYAQAM AGASTTSLPK
SSPSINPAES SESLAQTSGD RPKSQYGQKP GSLSGSSFLT GVLQKKRRKR NQGYARRFFS
LDLTSSTLSY YRNDHSSALR GAIPLSLAAI GANEETREIS VDSGAEIWQL RALNEKDFQM
WKTALDRASR TAADRGAVAS PTLQIQEGTF QGFPQASSAI EETEWARVEA LMGRVSGTRD
AVRRLVQQTE PKSATKTNET ESPAPSETEP SDYFPEQKAP QKTSFWKRKP SSSAAQSPSG
LSNKSGPSAN ISANGTLAVP SQNGQGTSSP MEELLHGNCM ALLKDLDSVV ADFANLISES
KQRRALAKPP PLSAVPSRNS FESTVESVDE FFDATDGDGG KSQLLTIRRD SGDNEHERGH
TPNEDSDGES ESSSENGSEE TRDRPRMSLE MTPALFPTKP ESLKPLPLDP VDRRATVPAP
KVQPPSLIAF FRKNVGKDLS TIAMPVSANE PTSALQRLAE QLEYSELLDA AVAAPSETGE
RLIYMAAFAI SAFSNTRVKD RAIRKPFNPM LGETYELVRE DKGFRFFAEK VVHRPVRMAC
QAEAQEWTFI QSSTPMQKFW GKSAEINTDG RVRIFLHASG EHYSWTLATS YLRNVIAGEK
YLEPSGTMTI ISETTGAKAV CTFKAGGMFA GRSEEVLVQA FDNAGSILPS GATGKWTTDL
QLTSNGQPIG KTIWKVGSLV DKAEKHYGLT TFAAALNQVT AIEEGHIPPT DSRLRPDQRA
LEDGDVDKAE ALKARLEERQ RARRKVLEEH GQEWKPRWFS KVGAAEAAAL DGEEIWRLKG
GKDGYWECRE RGEWGDLTEV FET
//
