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Database: UniProt
Entry: M2U8M8_COCH5
LinkDB: M2U8M8_COCH5
Original site: M2U8M8_COCH5 
ID   M2U8M8_COCH5            Unreviewed;       743 AA.
AC   M2U8M8;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE   AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN   ORFNames=COCHEDRAFT_1191688 {ECO:0000313|EMBL:EMD94909.1};
OS   Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS   corn leaf blight fungus) (Bipolaris maydis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD94909.1, ECO:0000313|Proteomes:UP000016936};
RN   [1] {ECO:0000313|EMBL:EMD94909.1, ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2] {ECO:0000313|Proteomes:UP000016936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA   Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA   Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA   LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA   Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector coding
RT   capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133}.
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DR   EMBL; KB445571; EMD94909.1; -; Genomic_DNA.
DR   AlphaFoldDB; M2U8M8; -.
DR   STRING; 701091.M2U8M8; -.
DR   eggNOG; KOG4132; Eukaryota.
DR   HOGENOM; CLU_405526_0_0_1; -.
DR   OMA; VEAKPKY; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000016936; Unassembled WGS sequence.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR   PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016936}.
FT   DOMAIN          36..297
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          316..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..332
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..456
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  83347 MW;  2F42DF9B42CC728C CRC64;
     MAEQSRGRVP ILLLKTKSVP MDTYEELFLG LDNGRYAPVF VPVLEHRFKR DALREVREHV
     TSRGLVPKSQ QGLATYGALI FTSQRAVEAF TEVIQEIRSQ ETYRVDDLLP ESLPLYVVGP
     ATARGLRALG LKCPILGEET GNGEALAGFI LQHYNALYTD TPNPPVLFMV GDKRRDIIPK
     TLQSAELEPN TRAKVDELVI YETGEMQSFK EDFSAIWKDN TKRGFERQWI VVFSPSGCQA
     MLESLDLLDA ETGRAKASTE QRNILIATIG PTTRDYLIQQ FGFTPDVCAE KPTPEGVAEG
     IKDFLEKRAH LSATRFLTHN SSNMSSPAKS SDVAAGTKRK HDVEPSPKRE TKAAKKQTTL
     EETMGSSKEK DEEMKDASDD GKNVKQTDKF EERVDEDLAD ASDEQALSND DNAKPSDTEK
     QGGNDSNTQS KVHTTTRDEE ENDSHNTTKE SVADGEGAIE KSSQRAKQVP SNVLEKGVIY
     FFTRNRVGIE ESESVGDLQR TFFVLRPMPV GAKLGDGPLA DDNNNRLFAL PKKVFPKSHN
     DRFMAFVEKA NVTIKELKEE FFSAEEYNTK TQGTRRVEPV APVAEGVYAI TRTEDRTCHL
     VYSTTIPSKL GEVQDDLGIR NQGSFIISVK NPERSGPAQA QLPQKPSFPQ EFIEEFRGLA
     WVEAKPKYLD YEYCQILLIG EKLESGVKPT TKDQKHDKET PLEEIEKLEH EDELRVEHLH
     GDDSVYDDLK ITKKEYPQVS TTW
//
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