ID M2UJG6_COCH5 Unreviewed; 3175 AA.
AC M2UJG6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=COCHEDRAFT_1227314 {ECO:0000313|EMBL:EMD88087.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD88087.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD88087.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KB445581; EMD88087.1; -; Genomic_DNA.
DR STRING; 701091.M2UJG6; -.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_225562_0_0_1; -.
DR OMA; DHINRED; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF16; NONRIBOSOMAL PEPTIDE SYNTHETASE ASQK; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 9.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936}.
FT DOMAIN 2626..2703
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 3175 AA; 354489 MW; D3D9E5EB299FCF1D CRC64;
MAPATADNLA VLGSGDILNQ NIVEVVPCSP LQEGILLSPS SYAVYWVWTC IPLVGACVDS
DKLETAWRAA ALEHSIYATI FASDNTGEGF LQVVLRNPTF SIQQITTKNG NMTAAHVLAM
RPRPKWTKAS PRHTLTICTN VATGQVACRF DICHTLYDVY SLRILLKDVV SMYHGRDITK
PAPFADVVRY IESRTEDQTS GFWSEYLKGS KSCRFPTLSL NETSNAIQDE HGAIRVPSKP
FDAATTFCSK HGITRSVFMH IAWALVLSHF NGGYDMSFGY MGSGRDAPVD GIDHICGPMA
NLLISRVDLA SPLQSLLRSI AQNLKEHRRH QQTYFAPIFH KLGLGGEPLF NTMINLLRAE
KEECQTDTLA FEKEVLISPH EFDLVLEGHL HPETIAITLY YRHGNISRDV AEEACTVLCR
ATGFLIESAT QSDLVKGPAG GTESPVSLPK GFCKYITGHD SPNTKEFWRH YLDGIENMSS
KTERYKGSER PKQYEVILDT PIESGHDFTL ESLAQVAWAI FLTEEYESNE VFFGTNFDSN
RSKLRHFTGL EERHATLMPC KFEVPPQATV RELLEGFQRL KDLLVANKSP GLHWLRQVNP
AVDRFTTAIT CQDDSLCDIG SMETVVRLES CPGNQVLHLT SYKNTPLQRI ARRFVHILRQ
LCRKDSLDIA WSTFVGICEE DIEEIHSWNS IAYPTSTQTV HGLFDIQLRK RPEVMAVCAW
DGSLTYSQLD KYSTLLAFHL LDQGIQPGSI VALCFEKSML MPISMLAVAK AGITGLGIDP
DQPEGRLAQV VTESKAAALL CSLRHHELSS RLGAKKALPL GLDDLSLMQL DDTRSLPTVK
SSDILYAVFT SGSTGKPKGV LVSHGSYSAA AICQHEPFGF SQEARVLDFS SYAFDAAWFN
LMHTITSGGC LCVPSTDDLR NHLGGCILQF GVTFAFLTPT VCRGIERKAL IHLKRLLLGG
EMIVPSDIAL FADNCIITLV YGPSECTPMT MFHNPENSVD IALGHGMGTK TWVVNPDNVH
QLCPIGTIGE LCLEGPLLGA GYLEDKLKTE QAFIRDLSWH RDPQAQIYRT GDLVKYIGDD
LGTLVYVRRK DTQVKLRGQR VELGEIEQHV HQAIMFGTPD HLEQPNLNIV AEVVHAEETE
NAVLVTFVSL RTNANQSEAD HQKTIRQLTV GISDRLEQVL PSYMVPTSYI PLSSIPTTIT
GKTDRALRAI IDRHSMLRAR YHRSSQGLWS QHIAPLGPWN MIEHAVSKPS EAFNMAKELQ
KQLNIVNGPV FLAVHFTVTN HRPLLLLSAH HLVIDLVSWR VIWRDLEDFI RNKCLLSARG
ISFRRWCKEQ HRESCNLMPD TVLPFAVPPY DTSFWGCASK DQVRGNAIDS TMILDRDSSQ
LLMGHSNDTM RTEPLDIILG ALAHSFGQSF PEHKMPTVFL EGHGREPLGI RRIDCRDTVG
WFTVIYPLPL PTKPNDNVVD AVCLAKDTRR RVPSKGQEYF ASRFYSETCR DAFKEHDAIE
ILVNFAGSYQ QLENDGGLFK LVPPPSNEEG MGTVAKGSPR LALIELEMLV RNGKLELTMS
LNKHMLHRDR LSIWQGRFLK TIRDAATALN CVPARITRAD VPLLSLSDAA LRYFNDIQLP
AMAISPKDII DAYPASPLQE GISLSAYQGL STYDTFWIWK CLPRNGEEKV DMAQLAEAWR
SVVRKHSILC TVMVPDPSGE GLIQLVLSEP EIKVICLEIH GQDPEDVLYQ LQRPLWTSQG
SPRHCFTVYQ SGVKTAFRLD INHALIDGGS LMPLIQDLRM AYNGFHSIAA PPFGEMIRYL
SQSNHQEKID WWGNYLHKTK PCEVLSIFNQ PIKGISHDNE RFRYVKIPQS ATVGVIGFCQ
RFGITRSVFL QVVWAMVLSY LTDAPDVCFG YLTSGRDAPI QDVDRMIGPL ANMLISKIQL
NQSASAVLRQ TSDDSIQHLL HQHVSLAQVQ HAMGLSAGRR LFNTAMTLRE SDRFDEDDAN
GKISFEYHDH QDPHEFDLLL SARVNSNDLD VSVQLPQDLL DNETTDKLTF ALTSAIDVLI
SSEVSYRQHA HIKENEETLF TNFKRIMTIS AQKRDLDLIW SWNCPLPDSI QRCAHDEIYA
VALQNWNQPA VCAWDGEISY GELEQMSTRV ANNLREQGIG RGHIVPICFE KSMWMPVAAL
GVMKAGAAVV ALDITLPVQR LQVITKQVQS DIILASLAQT DLAGRLGFAK LLVLPNHDEQ
PKEPAQIDGA VASSPDDLLY IVFTSGSTGT PKGTMLTHSH VCSMLHHQRE IIGLTSGRRV
YNFASYAFDV AWDDFFHALT SGGCLCIPSE EDRKNNIETS MAMLRANYVH ITPTILRHID
WSKATGISVV NLSGEPVAPS DRSILSRKTK VVNLYGPAET NVVTVQDLDE LTTQEVSIGK
GYGASTWIVD LKNSDILAPI GEIGELWIEG PLSGLGYLAE TTEFQKASWV KNPIWLTRGT
ERFPGRHGQL YRTGDLVRYT KDGSLIYCGR ADRQVKINGQ RVELGEIDVA LQALVKRLGH
DWHVAVETVQ SLESDVQVIM AFVAPRNVCI DEKQLENHIM QEASLLREQL RSVLPQYMVP
RAFVPLAALP LTATGKVNLR KLQAHGSSKS IREWVSGEKS SIEICPADTE SEKAMVRVCR
DVLQMSKTTS ISMNDNFFRI GGDSVLAMRL VSKARDIGYS LIVRDIFKHP VIRDLAKVAK
PQKSTTTHEL EVAPPVADKL LDDAEMRGHA AYTCNVTDDQ IVDMLPCTPL QRNLASWARL
HPKGHFRTTH QLELKQHTDI PKFKQCWDMV VERNPITRTH IVNLPKLGYT QVIVDRPSKW
IDGSTLEQCH KELASRHTLQ GEPLVNFALA RLASPTNQQS AWFLCDLHWA AYDGWSLRLL
LSEAQNLYHG RHPHPLNDMR VLTNSLWSCE LAKAESYWQN QFSGLTHAAL AFPQQQQQQP
LVCREDSTLL RPGDDHDASV VLQDFGCQGT GSGFTASTLI RAALGIVLAR HLQTDRVVFG
ATVTGRQGAA TGLDRMAGPA FVTLPICMSV DRGDPDVLGL LEKVQAQTMD MIPFEQTDLE
RWRYRIPGAD IACDFRVLLV VQSHIAQNDV RNHDPDLESV FTEGLKAGKD ALVELGWRSG
RRLPMFVECQ IQENGRLALR LRIDSRTADE HVFISLLQEL KQEMLNLNNI ATGAL
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