ID M2UPV8_COCH5 Unreviewed; 994 AA.
AC M2UPV8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=COCHEDRAFT_1225490 {ECO:0000313|EMBL:EMD89912.1};
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091 {ECO:0000313|EMBL:EMD89912.1, ECO:0000313|Proteomes:UP000016936};
RN [1] {ECO:0000313|EMBL:EMD89912.1, ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|Proteomes:UP000016936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O {ECO:0000313|Proteomes:UP000016936};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KB445578; EMD89912.1; -; Genomic_DNA.
DR AlphaFoldDB; M2UPV8; -.
DR eggNOG; KOG1134; Eukaryota.
DR HOGENOM; CLU_009187_1_0_1; -.
DR OMA; AYKPPWM; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016936};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..185
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 208..374
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 385..666
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 854..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 112914 MW; 6F610B86F2D4A0BD CRC64;
MVAERRQNAE SSLDRFIDLI SDPFQSQVQE TSIYAAIVYS FAVSGLLVLT FCFLRPRNSR
VYAPRAKHAD EKHRPLPLGN KPLSWLSAVR NVREQDLVDK IGLDAVIFLR FMRMIRNIFF
VLTVVGCLIL IPVNVVGGSP FYKQWSSIST LMKFTPQYIF GRKFWAYVAF AYMIQGTVCF
FLWRNYSAVL KLRRAYFDTE EYKSSLHART LLLTHVPQSY RTDAGLIKLI EQAKPIDSVP
RAVIGRNVKD LPKLIEDHDK TVRDLEKHLA KYLSNPNRLP ARRPTCKPAK DDQGIHGKNE
VDAIDYLTER ITRLETTIKE VRETVDMRNP MPYGFASYEH IEDAHAVAFA ARKKGPEGCD
VYLAPKPHDL LWQNLAMSRR TRTIRAFWDG LWIVLFTVAF IVPNMLTSVF LSDFSHLGLV
WPTFQANLSA HPTSWAIAQG ILAPLVQTLM YMGVPVVFRR LFTHSGDVSK TSRERHVTAR
LYSFFVFNNL LVFSVFGSTW RFVAAVIAAK DQGVWEAIRD NHLFTKIMSG LCNVSTFWLT
WQMQRNLGAA IDLSQAWVLL WSWIQRKCFS PTPRELIELS APQPFPYADY YNNYLFVTTV
GLCMGALQPV IFPVTAFYLA MDCVFKKYLL QYVFITKTES GGRFWRLLVN RTLFAVALAN
AVIALVVGAN GIGSINLNSL QMGTGNMLFA MVPLPFLLLG FKWYCKRSFD EKLSYYSTRP
FSDAEAAHAT DDRKQRKTNR LLTRFGHPAL YKKLLTPMVH AKSQHLLKEV YSNRSSTGHD
IFDTAQRRSI DRAMPATPGY ERFGDFIMTE MDSEEPGKQT ANADIPHVEI VAESELDFEN
FKKRAEFRDA FGGDGELYGR PEDVSRPGTP STFTTFTEMG PYGRHRGSAS ASPSSSRTRL
GDGGDFEQGT SYAKGYQRPS RPAEEGYEYE DIGDDADMSP VTPLHTDVML HGVHSRQPLV
GTENRHSNNA PGHHGLGTAA AHEDTSYERF RHKR
//
