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Database: UniProt
Entry: M2W461_GALSU
LinkDB: M2W461_GALSU
Original site: M2W461_GALSU 
ID   M2W461_GALSU            Unreviewed;       362 AA.
AC   M2W461;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Sterol-4alpha-carboxylate 3-dehydrogenase (Decarboxylating) {ECO:0000313|EMBL:EME30536.1};
DE            EC=1.1.1.170 {ECO:0000313|EMBL:EME30536.1};
GN   ORFNames=Gasu_22080 {ECO:0000313|EMBL:EME30536.1};
OS   Galdieria sulphuraria (Red alga).
OC   Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC   Galdieria.
OX   NCBI_TaxID=130081 {ECO:0000313|EMBL:EME30536.1, ECO:0000313|Proteomes:UP000030680};
RN   [1] {ECO:0000313|Proteomes:UP000030680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX   PubMed=23471408; DOI=10.1126/science.1231707;
RA   Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA   Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA   Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA   Lercher M.J., Weber A.P.;
RT   "Gene transfer from bacteria and archaea facilitated evolution of an
RT   extremophilic eukaryote.";
RL   Science 339:1207-1210(2013).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; KB454499; EME30536.1; -; Genomic_DNA.
DR   RefSeq; XP_005707056.1; XM_005706999.1.
DR   AlphaFoldDB; M2W461; -.
DR   STRING; 130081.M2W461; -.
DR   EnsemblPlants; EME30536; EME30536; Gasu_22080.
DR   GeneID; 17089260; -.
DR   Gramene; EME30536; EME30536; Gasu_22080.
DR   KEGG; gsl:Gasu_22080; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   OMA; AYEAFGY; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000030680; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0103066; F:4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0103067; F:4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000252; F:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; IEA:UniProtKB-EC.
DR   GO; GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; EPIMERASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475,
KW   ECO:0000313|EMBL:EME30536.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT   DOMAIN          5..266
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   362 AA;  41040 MW;  3E8F884373719BD2 CRC64;
     MFSCVVVGGS GFLGQALVQR LAVNKNKWER IVVFDIKNVT QSRGTGAVVF QQGDIRRQDD
     LVAAFKDASV VFHCATAAPS AENAKNKEIM YTVNVEGTRN VIEACKICHV RSLIYVSSAS
     VVFRGQDLEG VDESIQIPKR HVDFYTETKA IAERAVLDAN SSQLHTCCLR PSGIFGERDP
     LFVPTLISNA RKGKMKYYIG DGTNRMDWTF VDNVAYALEL AADGLQQSSQ RIGGQVYFIT
     NDDARPFWGF LGDILQGLGY ASHSSHELII SYQELCRYSR PTRRLPFWLI YILSWLFLWF
     SRLISPWIQL ESDFTPFRIL LSVRNRRVSC EKAKRELGYK PIVSMEEGLQ RTIAYFSFLR
     NP
//
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