ID M2W856_GALSU Unreviewed; 352 AA.
AC M2W856;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Myo-inositol 2-dehydrogenase {ECO:0000313|EMBL:EME32051.1};
DE EC=1.1.1.18 {ECO:0000313|EMBL:EME32051.1};
GN ORFNames=Gasu_07960 {ECO:0000313|EMBL:EME32051.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME32051.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family.
CC {ECO:0000256|ARBA:ARBA00010928}.
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DR EMBL; KB454488; EME32051.1; -; Genomic_DNA.
DR RefSeq; XP_005708571.1; XM_005708514.1.
DR AlphaFoldDB; M2W856; -.
DR STRING; 130081.M2W856; -.
DR EnsemblPlants; EME32051; EME32051; Gasu_07960.
DR GeneID; 17090653; -.
DR Gramene; EME32051; EME32051; Gasu_07960.
DR KEGG; gsl:Gasu_07960; -.
DR eggNOG; KOG2741; Eukaryota.
DR OMA; FRDHPCP; -.
DR OrthoDB; 1992171at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42840:SF3; BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED; 1.
DR PANTHER; PTHR42840; NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EME32051.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT DOMAIN 6..123
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 141..333
FT /note="Gfo/Idh/MocA-like oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02894"
SQ SEQUENCE 352 AA; 39822 MW; C6D39E6706529A86 CRC64;
MHKALRLVVV GTGRMGKIHI YNAATSLKVK LVGVYDIPEK RKEASKLVAE TGSKLYEDWH
SQVLANTEVD AIVIASPTHT HKTLTLDALE SGKSVLCEKP LGEDFIEIQM CHQKAKEKGL
TLLIDWNRRL DPSFMKLVSE VRKGFIGQLQ IIRVSGRDHP VPPLQFLRHS NSCIFRDMIV
HDVDLVRWIM NSEPISVYAT ATSCLPELAG SGIYDTATAL MEFKNGAVAM LDSARNACYG
YDQRLEVFGD KGMLSVENFP SNGVTWCNEN GIKKEPYVWS FPQRYQISFR NVLEHFADVV
LRKHLPMCSE EDDFGIYKVV SAMSLSASLK RRVFLDEMNE KFLLQQNTNH KL
//
