ID M2WTI3_GALSU Unreviewed; 309 AA.
AC M2WTI3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Ribosomal large subunit pseudouridine synthase D {ECO:0000313|EMBL:EME27210.1};
DE EC=5.4.99.12 {ECO:0000313|EMBL:EME27210.1};
GN ORFNames=Gasu_51910 {ECO:0000313|EMBL:EME27210.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME27210.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC {ECO:0000256|ARBA:ARBA00010876}.
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DR EMBL; KB454535; EME27210.1; -; Genomic_DNA.
DR RefSeq; XP_005703730.1; XM_005703673.1.
DR AlphaFoldDB; M2WTI3; -.
DR STRING; 130081.M2WTI3; -.
DR EnsemblPlants; EME27210; EME27210; Gasu_51910.
DR GeneID; 17086138; -.
DR Gramene; EME27210; EME27210; Gasu_51910.
DR KEGG; gsl:Gasu_51910; -.
DR eggNOG; KOG1919; Eukaryota.
DR OMA; DCHENIR; -.
DR OrthoDB; 5479603at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF44; PSEUDOU_SYNTH_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:EME27210.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT DOMAIN 80..142
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 309 AA; 35016 MW; 808CAEB41C7148F8 CRC64;
MRTLFVAPLV TTSFRLGAFC KNIFTNVRIR RTKQILYMRP FVSSASWKEF LVDKPEEDSD
ASEQIDQVSS FRVSPDEVGQ RIDKLLALRF PEQSRTYFEK LIEKRLVRLN GSNAVTKSFR
TRLGDEIEVT FLVSPEFRFE AQNIPLNILY EDNHIVVINK ASDMVVHPAP GNWNNTLVNA
LAYHLGVHSL DDCHENIRPW IVHRLDKGTS GVLVTAKTDI AQRNLMQAFK SRNTKKSYIA
VCYGNPMTRL HVLSGNNIMD MPIGRSHSNR LRMEVVPLEK GGKEAITVIE GDASNSSAST
PLCFLYSGR
//
