ID M2XG05_GALSU Unreviewed; 290 AA.
AC M2XG05;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=mRNA (guanine-N(7))-methyltransferase {ECO:0000256|ARBA:ARBA00011926};
DE EC=2.1.1.56 {ECO:0000256|ARBA:ARBA00011926};
GN ORFNames=Gasu_35370 {ECO:0000313|EMBL:EME28962.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME28962.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC Evidence={ECO:0000256|ARBA:ARBA00024288};
CC -!- SIMILARITY: In the N-terminal section; belongs to the dsDNA virus mRNA
CC guanylyltransferase family. {ECO:0000256|ARBA:ARBA00008556}.
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DR EMBL; KB454513; EME28962.1; -; Genomic_DNA.
DR RefSeq; XP_005705482.1; XM_005705425.1.
DR AlphaFoldDB; M2XG05; -.
DR STRING; 130081.M2XG05; -.
DR EnsemblPlants; EME28962; EME28962; Gasu_35370.
DR GeneID; 17087797; -.
DR Gramene; EME28962; EME28962; Gasu_35370.
DR KEGG; gsl:Gasu_35370; -.
DR OrthoDB; 167537at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004971; mRNA_G-N7_MeTrfase_dom.
DR InterPro; IPR039753; RG7MT1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12189:SF3; MRNA (GUANINE-N(7))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12189; MRNA GUANINE-7- METHYLTRANSFERASE; 1.
DR Pfam; PF03291; mRNA_G-N7_MeTrfase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 77..282
FT /note="MRNA cap 0 methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF03291"
SQ SEQUENCE 290 AA; 33867 MW; 9FF35FE054A0FEB1 CRC64;
MSHLLLTRDR SFGRLRNILR WTSESLTFQL VDDNSHVCLF CVYPAFCLGP LLYAFPDSVQ
LLTVVCWTRE DCQQAEQFVQ QQYPNRFHCQ YVHCNCEETS LASVLTEKYD IILCWGWLER
LFSSLELVKD FLTQVSLKLQ PKGFFAGITI NSSYIWTMAQ KYLERHAAAS YPMIIENPLW
TLILLQGDVF SSIGTPLSIR YHSEMRTSRL PETEYLVHAP TLFHYCDAFG LEWIDWLSGR
DWWSAHKNIG FQRLMEMGVI TKDSRHLSKE EYELLGIFAC FITIKHSSSQ
//
