ID M2XQP3_GALSU Unreviewed; 590 AA.
AC M2XQP3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Nucleobase:cation symporter-2, NCS2 family {ECO:0000313|EMBL:EME25759.1};
GN ORFNames=Gasu_65800 {ECO:0000313|EMBL:EME25759.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME25759.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; KB454850; EME25759.1; -; Genomic_DNA.
DR RefSeq; XP_005702279.1; XM_005702222.1.
DR AlphaFoldDB; M2XQP3; -.
DR STRING; 130081.M2XQP3; -.
DR EnsemblPlants; EME25759; EME25759; Gasu_65800.
DR GeneID; 17084753; -.
DR Gramene; EME25759; EME25759; Gasu_65800.
DR KEGG; gsl:Gasu_65800; -.
DR eggNOG; ENOG502QQD4; Eukaryota.
DR OMA; GLGFDWN; -.
DR OrthoDB; 911690at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 2.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 590 AA; 63633 MW; 5D5BF25E6AE8E3D1 CRC64;
MQTKSKNRLK QVYQHIVQKV TTLHGWIGNY EYGRLFTPRI PYLFHSKTTP PFLAHKEELP
ILAAAIVGFQ HALAMMGGIV TVPLILSGSG SNNLNLDDSY RTYMVASALI ASGILSIIQI
TGLKIRKTGY QLGTGLISVV GTSFTTLPVA QAAFSTIRKH GEYNCSLEGP CPEAFGAMLG
TIMVCCWLEV AISFLPLTIL RRVFPPLVTG SVVVLIGASL VASGFQDWAG GSGSCYNYSR
AVSNLEALGV ENISAILPSS LSICPSSQYA YQKYPFGDAK WIGLGSIVFL TIIVIEIFGS
PFMRTAEIMI GFLLGLLVAS VLNYTNIESV QGAPVITFLW TKTFPIRFYP PAIIPLLIVF
VVLAIEAMGD VTASMEASQL PIIGKEANGR LQGGILADGL NAFLGALMTT FPYSTFAQNN
GVIAMTRCAN IWAGYWCCLF LIVFGIFSKI SALFVAIPDA VLGGMTTFLF ANVVTSGIRI
LCFVDWTRRS RFIVACTLSI GLGATLLPEW FSSVIPSVEQ NSALQGLIQG IDIIMSTGFC
IGAFIAVFLN LILPVDEDCQ KEDMSRVGNQ ASLTESSVTI QGLITDEDIK
//
