ID M2XUJ0_9MICC Unreviewed; 849 AA.
AC M2XUJ0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=C884_00460 {ECO:0000313|EMBL:EME36473.1};
OS Kocuria palustris PEL.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Kocuria.
OX NCBI_TaxID=1236550 {ECO:0000313|EMBL:EME36473.1, ECO:0000313|Proteomes:UP000009877};
RN [1] {ECO:0000313|EMBL:EME36473.1, ECO:0000313|Proteomes:UP000009877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEL {ECO:0000313|EMBL:EME36473.1,
RC ECO:0000313|Proteomes:UP000009877};
RX PubMed=24504000;
RA Sharma G., Khatri I., Subramanian S.;
RT "Draft Genome Sequence of Kocuria palustris PEL.";
RL Genome Announc. 2:e01261-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EME36473.1}.
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DR EMBL; ANHZ02000014; EME36473.1; -; Genomic_DNA.
DR RefSeq; WP_006214881.1; NZ_ANHZ02000014.1.
DR AlphaFoldDB; M2XUJ0; -.
DR STRING; 71999.KPaMU14_07020; -.
DR Proteomes; UP000009877; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EME36473.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009877};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 27..480
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 808..849
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..479
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 849 AA; 91595 MW; 5C1F1B3363E659CB CRC64;
MAPRRSKAQK SALDELPADF EGNVVDIDVT REMEDSFLEY SYSVIYSRAL PDARDGLKPV
QRRILYMMDE MGLRPDRGHV KSARVVGEVM GKLHPHGDSA IYDAMVRMAL PFAQRMPLVD
GHGNFGSLDD GPAASRYTEA RLAPAALQLT ADLGEDVVDF VPNYDNQFMQ PSVLPAAYPN
LLVNGTTGIA VGMATNMAPH NLREAVAGAR HLLEHPEASL EDVMKHIPGP DLPSGGQIVG
LDGIRDAYRT GRGSFKTRAA VSIEQVTPRK QGIVVTELPY MVGPEKVIDR IKSAVQSKKL
TGISDVVDLT DRTKGLNLVI EIKNGFNPQA VLAALYKHTP LEESFGINNV ALVDGRPQTL
GLLEMLRVYN QHRLTVVRRR TAHRLGKRRD RLHLVEGLLI AIVDIDEVIQ IIRSSDQTAE
ARERLMTIFD LTQLQADHIL ELRLRQLTKF SRIELERERE ELEREIAELE AILASEDRLR
EVVSGELAAV AELLGDDRRT RLLEADEAPA LLAAPAAKAA AGPALEIADD PCWVFLSSTG
RMARTNDRTP LAEPGRRLKH DALRSVVATS ARGEIGALTS SGRMIRVPVM DLPALSSYDG
APRLEEGTAA KDFLSLAKGE RLIGLAALNE VVAMGTRQGV VKRLNGDHPL NRDDWEVISL
KDGDEVVGMG PAPDSAQLVF ITAQAKLLTF SAELVRAQGR TAAGVAGIKL ADDDSVVFFG
PVASQDPDAR VVTYARSSEA LPKMGGYSVK VTPLSEYPSK GRATAGVRCQ RLLSGETGLV
LAWAGHGPAK AVSAAGVARS LPTEFGRRDG SGVGVEQLPD AIGPAWSPVS SAASAAEGAD
GDAESEEQA
//