ID M2Y1X4_GALSU Unreviewed; 593 AA.
AC M2Y1X4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=ATP-dependent DNA helicase 2 subunit 1 isoform 1 {ECO:0000313|EMBL:EME29814.1};
DE EC=3.6.4.12 {ECO:0000313|EMBL:EME29814.1};
GN ORFNames=Gasu_28150 {ECO:0000313|EMBL:EME29814.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME29814.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB454505; EME29814.1; -; Genomic_DNA.
DR RefSeq; XP_005706334.1; XM_005706277.1.
DR AlphaFoldDB; M2Y1X4; -.
DR STRING; 130081.M2Y1X4; -.
DR EnsemblPlants; EME29814; EME29814; Gasu_28150.
DR GeneID; 17088584; -.
DR Gramene; EME29814; EME29814; Gasu_28150.
DR eggNOG; KOG2327; Eukaryota.
DR OMA; FWANVKH; -.
DR OrthoDB; 21093at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006165; Ku70.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR NCBIfam; TIGR00578; ku70; 1.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF2; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF02037; SAP; 1.
DR PIRSF; PIRSF003033; Ku70; 1.
DR SMART; SM00559; Ku78; 1.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50800; SAP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EME29814.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EME29814.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680}.
FT DOMAIN 554..588
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
SQ SEQUENCE 593 AA; 68724 MW; 58C5CCAFCCB1404A CRC64;
MYDENEDKVP LITLALNCIK EIFKSRIISD TGDLLGVVLF GTSKVNNPND LASIYVLLEL
DVPDPESILY LETLEKTPQW MMSQLGSLER YAKVKFQELL FTCRSLLNHA VRSKTLNVRK
RLLLFTDDDD PIENDENVKN LNIRQARDLS ESGMNIELLP LKSSRSKPFD YHLFYEDVIG
SSRQELEPVS DPISRFEELQ LHILKKKYKK RVLNNTFLYL NGLQNEGAHA ELETVGLEVY
ALFHRPSRSK KVFLEARNNE PVRRVTIAYS EESGALLANA NDIRYSFPFA GVACVFTHSE
MEELGHLCRY GMELIGFENK NKLKWQYNMR PSYFLYPSDH TIKGSQLLMA VLWKQMLQEN
QIAIVRVCFR RTSHPRLAAL VPQDEKKTES HLQTEPCGFH LIWLPFAEEI RKEWKKQYPK
WNNLPSQQCV EAAMNVISKL SMPSYDPSKY SDPDIQRYYN GLQALALNQT NFPQVEDTLD
TDDAQMAQVA KEELEEWTKI VASEPVGIIK QEKSLRSPKR FHIKRAVEKL RSKQFLEQQL
DWKQLAFDKG NDGLEKQNVT TLKMFCAAHD LKKSGRKAEL IERIRTYLET EKA
//
