ID M2Y950_GALSU Unreviewed; 902 AA.
AC M2Y950;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Monovalent cation:H+ antiporter-2, CPA2 family {ECO:0000313|EMBL:EME32364.1};
GN ORFNames=Gasu_04550 {ECO:0000313|EMBL:EME32364.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME32364.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB454486; EME32364.1; -; Genomic_DNA.
DR RefSeq; XP_005708884.1; XM_005708827.1.
DR AlphaFoldDB; M2Y950; -.
DR EnsemblPlants; EME32364; EME32364; Gasu_04550.
DR GeneID; 17090952; -.
DR Gramene; EME32364; EME32364; Gasu_04550.
DR KEGG; gsl:Gasu_04550; -.
DR eggNOG; KOG1650; Eukaryota.
DR OrthoDB; 1214757at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00022538};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 193..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 594..716
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT REGION 756..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..892
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 97560 MW; 0D0729AA867B7D61 CRC64;
MLNAYYPLQE DLQLCSTRKF LKTCCNGLSL CFSFIPEKIS LRRDFKLSLG FQQRLVSRKQ
HKLDSLNTSS RRVFCCVEKP PLKRLSFPWS LALLTLSLLW PRSRIASAST FEAFHLESNY
PYAVEFHKSS LIKNPSSNCR RIALVVQRKE KKSKSVKEAS DALFLKNRSS LFSELFRVGS
FWKVLSIHIP STVSDTLVLL LATIIVVPIM RKLNTSPILG FLIAGLVLGP NGFHLVRDVV
ASRTLAEWGV VFFLFEMGLE LSLDRLRKLQ KDVFELGLSQ FLICGAAFAI SAMIAGLPLE
TCAVIGGGLA LSSSAFVLQL LSERGEIGTR FGRASFGILL LQDIAVVPLL VVIPLLATKS
GGPKVLVSAL MVAAMKASVA LAVIFATGRL FLEKVFRTVA AAKSPEAFVG VILFTVLSTS
AVTEGLGLSD TLGAFLAGVL LAETKYRHQI EADIAPFRGL LLGLFFITVG FSIDLKLALA
NLPVVSSLVL GLLTMKAGII TVLARLFGLS FSNAIRTGLL VAQGGEFAFV TFGAAQRAGL
LPADLSQLLL LVVALSMATT PLLSSIGSQL ASRIERRRGL IGARSEDIAD ARDFVIVAGF
GRVGQSICEM LNARLIRYVA FDMSPSRVIE ARNKGLPVFF GDACRPEVLE AAGVSRAKAV
VITLDDPVAA SRAVQSLRRE YPDLQIFVRA RDTKHQQTLQ LAGATAIVPE LLESSLLLGG
AVLLAYGTPI EEVNALIDEA RKKTFKEAGL SIGTSALNPR SPFSPSSETK TKKTTSSSLI
SSLDETNDNS SSSLNESKMI TSNLLEESHV VSTTPSVDKM EMAAVEEDDT SHSASLPSSQ
EKNISTNLAQ EKEVHFPIKE EPSTSSNGSQ QDDSSLEKIV GQHKKSEDPI ISTTESLDDS
VR
//