ID M3AB53_STRMB Unreviewed; 626 AA.
AC M3AB53;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311};
GN ORFNames=H340_01144 {ECO:0000313|EMBL:EMF02409.1};
OS Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1223523 {ECO:0000313|EMBL:EMF02409.1, ECO:0000313|Proteomes:UP000011740};
RN [1] {ECO:0000313|EMBL:EMF02409.1, ECO:0000313|Proteomes:UP000011740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40847 {ECO:0000313|EMBL:EMF02409.1,
RC ECO:0000313|Proteomes:UP000011740};
RX PubMed=23558536;
RA Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT Transglutaminase.";
RL Genome Announc. 1:E0014313-E0014313(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF02409.1}.
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DR EMBL; AORZ01000002; EMF02409.1; -; Genomic_DNA.
DR RefSeq; WP_004938015.1; NZ_AORZ01000002.1.
DR AlphaFoldDB; M3AB53; -.
DR STRING; 1223523.H340_01144; -.
DR PATRIC; fig|1223523.3.peg.236; -.
DR eggNOG; COG0749; Bacteria.
DR Proteomes; UP000011740; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
FT DOMAIN 2..186
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT DOMAIN 370..553
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 607..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 70083 MW; 5A0CAAAFB8554497 CRC64;
MINVLEDSGD IPEFVEWVRR NRSALGCDTE TTGLDWWADD FRLRLVQFGN HDESYVLPVE
LSDELLGAAV GAIRFVNKLI FQNGSYDLLV LDATTDLTME EIWPKVLDTK ILAHLVDSRG
EADAGIGHSL ASLTKHYIDD GVAAKIKGSM AEIARSLKTT KARVWKLVAW NHGGYLTYSG
LDPILAFRLG RILIPKLPRT VYRKTDIGPG IPPMNLIEFE HKVAEICALM SRPGIALNRD
YALRLEARLA LEEHRWTARA QELGCENPWS TEQCADAFEA RGITVFDTTP TGNRKVDKVF
LADWRARGDE LAEAIYQAKA ARKKRNTWLR SFLESVDSNG RIHPSINSIQ ARTARQSIQG
IPAQTLPSGD YEIRACFEAN EGHIVLSTDY SNMELRFLAA HSGDKRMLRA FRNGEDLHQV
TATAAGVSRK LGKMTNFLIV FGGGPEALSS QAGIPVHEAK RIMDIFMETY PGVEAFMKLK
TQEARRQGYV TTPSGRRLYV EKKFAFRGTN YFVQSGSRDI TCRALVRLHH AHLAQFALLP
IHDEILFSVP IEHADTAAKM TDELMKETVL GLEIPTDPDR GGKSWGSLYM KGVENLTKLD
DYYRDNPEQA LADDRRRNPD DHAAAA
//
