ID   M3ARN4_PSEFD            Unreviewed;       648 AA.
AC   M3ARN4;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EME79718.1};
GN   ORFNames=MYCFIDRAFT_81197 {ECO:0000313|EMBL:EME79718.1};
OS   Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS   fungus) (Mycosphaerella fijiensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX   NCBI_TaxID=383855 {ECO:0000313|EMBL:EME79718.1, ECO:0000313|Proteomes:UP000016932};
RN   [1] {ECO:0000313|EMBL:EME79718.1, ECO:0000313|Proteomes:UP000016932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIRAD86 {ECO:0000313|EMBL:EME79718.1,
RC   ECO:0000313|Proteomes:UP000016932};
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC       {ECO:0000256|ARBA:ARBA00006743}.
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DR   EMBL; KB446562; EME79718.1; -; Genomic_DNA.
DR   RefSeq; XP_007930365.1; XM_007932174.1.
DR   AlphaFoldDB; M3ARN4; -.
DR   STRING; 383855.M3ARN4; -.
DR   GeneID; 19341810; -.
DR   KEGG; pfj:MYCFIDRAFT_81197; -.
DR   eggNOG; KOG0564; Eukaryota.
DR   HOGENOM; CLU_025841_2_2_1; -.
DR   OrthoDB; 1381745at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000016932; Unassembled WGS sequence.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00537; MTHFR; 1.
DR   Gene3D; 3.20.20.220; -; 1.
DR   InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse-like.
DR   NCBIfam; TIGR00677; fadh2_euk; 1.
DR   PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF02219; MTHFR; 1.
DR   SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016932}.
FT   REGION          614..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..648
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  72510 MW;  88A37F479AD85FC0 CRC64;
     MHISEKLAAA HAKGQHTCSF EYFPPKTAQG VQNLYDRMDM MHALGPAFID ITWGAGGRHS
     SLTCEMVKVA QSAYGLETCM HLTCTDMERS KIDNALQEAY KAGCTNILAL RGDPPREQEK
     WEAKDGNFRY ALDLIKYIKK TYGGHFDIGV AGYPEGVDDT TSADEHIKYL KEKVDAGGTF
     IVTQMCYDAD IFIDWVKKVR AAGIPESVPI IPGIMPISTY AAFLRRANWS KARIPPQWLE
     VLEPIKNDDS AVRDAGCDLI VEFCRRLMDS GIMHLHFYTM NLAAAVRMVL EKLDLTPPAE
     SPHPDIKPLP WRQSLGLNRR DENVRPIFWR NRNRAYVART QDWDEFPNGR WGDSRSPAFG
     GLDEYGIGLK GTNENNRKIW GEPKTIKDIV NLFVGYMRGK VESLPWSEAP INEEANTLVN
     DLVALNSRGL LTINSQPAVD GVKSSHPVYG WGPRNGYVYQ KQYLEVLVSP DLIGTVIRRM
     EQDPDITYYA VNCNGELKTN APTDGGPNAV TWGVFPGKEI VQPTIVETVS FLAWRDEFYH
     LGMEWSKCYE EGSESRKLIK EITQSWFLVN IVHNDFRQQQ GIFPIFDGLK VSGLDEVAYT
     NGVNGMNGFN GVSGHTHNHE KPATNGVPDG NNVVNGADKA SSNSTLKH
//