ID M3ASX5_PSEFD Unreviewed; 6685 AA.
AC M3ASX5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
DE Flags: Fragment;
GN ORFNames=MYCFIDRAFT_93876 {ECO:0000313|EMBL:EME80592.1};
OS Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease
OS fungus) (Mycosphaerella fijiensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Pseudocercospora.
OX NCBI_TaxID=383855 {ECO:0000313|EMBL:EME80592.1, ECO:0000313|Proteomes:UP000016932};
RN [1] {ECO:0000313|EMBL:EME80592.1, ECO:0000313|Proteomes:UP000016932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRAD86 {ECO:0000313|EMBL:EME80592.1,
RC ECO:0000313|Proteomes:UP000016932};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; KB446561; EME80592.1; -; Genomic_DNA.
DR RefSeq; XP_007929480.1; XM_007931289.1.
DR STRING; 383855.M3ASX5; -.
DR GeneID; 19342870; -.
DR KEGG; pfj:MYCFIDRAFT_93876; -.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_222946_0_0_1; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000016932; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 6.
DR CDD; cd19542; CT_NRPS-like; 2.
DR CDD; cd19545; FUM14_C_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 6.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 4.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 6.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 6.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016932}.
FT DOMAIN 647..723
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1750..1826
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3312..3388
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4399..4477
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5513..5589
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 6610..6685
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4622..4646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 6685
FT /evidence="ECO:0000313|EMBL:EME80592.1"
SQ SEQUENCE 6685 AA; 733630 MW; A74133BD7AB87623 CRC64;
MGRLPPEEVR LTLHYDGMCI TATHATWLLN HVSAVLSRVS KEEEGQRVEE LFHPSTAEVD
SIHDAIYRPA IAAPTGACIH DLIFSHAQRD PNRIAVAAWD GELTYAQLCR LARTLAQHLA
WRGIGRGCKV PLCFDRSSAV IVAMLGVLTS GASLVLLDPA HPDSRLRAIV HRIGATLALV
SEAHRARFSD DCNSLVVDRA FLDALAESGQ LAEPASSVTA TDLAYILFTS GSTGEPKGVL
MEHGAYVSSA QQYGRALHLD HHTRALHAAS YAFGAALGET VLVLLCGGCV VVPHEEDRAV
HRLGAVMRRQ HVSWTAQTPS VAHAAGLQPS QVPSLKTLVL AGEPLTPQLR DAWADSVTLL
YAYGQSETAS ICSVAHVRRE SDVRDLGHAS GARIWLVDPR SSDDELRLVP RGCLGELVVE
STGVCRGYLA NTDHARAAAL PVPAWAAARR RAHVNGRRLA PKSLFYRTGD MGRYAEESMS
ILYCGRLDDQ IKIRGQRIEL REVELVVAEL FPSGSVRVLA DVVRRDADAD ADTDAAVVHL
TVFLVTDNTD DTDNTDNAAR AHHPDSHHAP ISLATDAGDE PYVRSHVRPE LARRVPYYML
PSLWLRIPSI PKTAAGKLDR KTLRRLGVEF LHQQAARSHT STAMYELPST PAQRTLQRLW
AQVLPHSAHA IGADADFFHL SGDSVRAMKL RALARDHQLR LSMEDIFRRP KLRDMAEALC
LLPPESKSLH IKPFALLGDG GDKVVDEEDF SARAALACGI ADDEVEDVYP CTPLQAGMMA
LSLASSHSGY VTQYVLELKK AIDVDRWLDA WEETIRSLAI LRTRIVALRH GEREQMVQVV
TRVDKSVSIV SASDDLDSFL AEHRRSLGLG QPLARIAHVS IGPQSYFVWT SHHALYDSWS
LRLILRTVSQ RYLHLSPPET LPFNSFIGHL VHSSRKDAGW EDFWRKYLDG AEDCPFPPHL
PSTSESNTHL QNSLERFCSL DASRSDSTPG ITRATIIYAA LAIVLGSYAA SQDIVFGATV
SGRAAPLFGI EQVAGPTIAT IPVRVRLDGK DQKVTDFLYD LHRQTTATMP FEQAGLQNIS
GLSPSAERAC AFRTHLSILP EEDPIMQMRS FGELRSEYLT DPTNYPLLVQ CELQEGGILT
RIKFDASLLP HDVVDHFLGA FTLVLQQLAQ TTDTQKVGDI ELTDAQHPES VWQWNENVPT
ACHTLVHELI FEQARIHYAT SPAICAWDGE LTYGELDVLS DQLARCISRL AIDVGHECVV
PLCFEKSMWM PVAMLGVMKA GAVSLALDVT QPQGRLQTIT SQVRRRLFLC SNSTAHLANE
LASWANDGRS DQQASVLVVD EVLKEKSVNH ADALPVASRG VKPENALYMV FTSGSTGVPK
GVVITHMNFS TALVVQKDRL GLKRHSRVLD FSSYAFDMAW HNLLHTLYAG ACFCIPSESE
RINDLSGSVH RYKATFANLT PKVADVLDTS ALNALEALEV GGELATVGQA ERWRKHTRVR
WFYGPAECSA ISSISADNVP PSNIGPGGVG LCTWIVDPYS PTRLCPMYAV GELVLEGPLV
ARGYYNDPER TAESFIDSPQ WLMQRGRRSR VYRTGDLVKY DLSGDLIFLG RRDGQVKIRG
QRVELGDVEH HVTGVLRDES GFPDAQVAAE MVTPKDSRNS ILVAFVARPN NIALEETRAH
LVKVAASISR RLSHMIPPHM IPSGYIVLSD IPLSSTGKTH RQQLREIGAR MKAMEIVGTA
ESCMPSKQGR PLSATEALLR TQWADVLGRD VEDVGIDDTW FQLGGDSIAA MRLVASCMSK
GIPMQVQEVF RRLTIANLAA WLQEKQKNLG PKQSRMKSFQ IRKDTVNEPF DLSPMQRLYL
SFNPTADVRF HQYINCRLAR PITREQLDGA LLVLTERHAM LRARLRDRDY HTTTPVRSAD
RFYQIITDDS SSSYHVEHHQ LPISESEIDE EKVIAAIQTR LNVTQGPLLV AALLDVGHTQ
RLWLTCHHLF VDYISWGSIL EDLEVLLTAN NPKLPALVSV SYQQWCKAQQ EYAHAHLDSS
AQALLPFQLR ARECTYWAPE AAPNAISTQN TWENSAFADF LLDPAPTMAL LGRSCNDALD
TRPVELLVAA LIHSFATIFP DRAQPLTIHN EGHGREPFLD GLDVAKTVGW FTTLCPIQID
GTASQSILDV VARVKDCFRS IPSNGWAFFT SRMLNDKRPP EVEEVVFNNA IGALQPTGAR
RKEAFLQPLD HDLKHPWAAF ASERRFALFD IVTRMRGERL QVLFAHSTRI KHQDRIARWI
LAYKHSLIEL ATVLPTLSRT FTLTDFPLAF KNYADLSVFE TTILPALGLS VDEVEDIYPC
APVQKGILLS QSTRPELYRV HYEIELRPAV DVAQLQDAWH QVIRRHAILR TLIVADMPGS
GFAQIVLKSF EPQLGVSSAP DDSCGKKQRP RPEHELIIEH ADGTCMAVSL KINHALIDAH
SYNVLLQDLQ QAYTGLASPT PPASTFKDYV KYVESQPLDD AREYWKERLS NVEPCNFPSL
DGDGPRSENT KILQVETPPI DHAKLQRFCE RYNVTVSSIC QAAWALVLCA YTGNNESACF
SVASSGREHP IPDIDRIVGP LIVAQPCIFQ LQQPEELTLL QLVRSAQAEH LRSMTRNLLP
LAEILHSASI TTIPFNTGIS VTTGPQGSAQ GYGKGLSIRT LKGHDPTDFD LTVHITVTRT
STSISLMYRS SLLHPSLASS VAGSLCAVLE SILSSPNAKI SDVESIGSED LQKVWNWNSD
APPKHERLLH DLVAEQVNLR PNALAIEAWD GKLTYRELEH LSNSLALQLQ ELGIKPESLV
PLLFEHSVWV VVAMLGGLKA GGAFVPLHPD RLVATLDQIQ PTVILTSPQY AETPEFESYK
VLIVGPETIQ PLPTNLTTSS SSSPENAAYT IFTSGSTGSP KGVIIPHSAI CTSILSHGPV
MSFTPTSRVL QFASYTFDAS IQEIFTTLVF GGCICIPASN SDLDTVIQEY QITWAVLAPS
LSKTLKPETV GGLKTLVLCG EKVTKNALQD WTGLENVMVG YGPTECSIVC VTGRGTIEDL
ERKSLIGKAV GCHTWIVHPD NLSKLVPIGA VGELVVEGEG LARGYLNDTD KTRTSFFEDL
GWLEKRRKGR VYRTGDLVRW GFDGRLEFLG RRDEQVKVHG QRVELGDVEV QLQGFLADGK
GRGRGRDVVV EAAQLAGRDS STLVAFVEIG GGGGGGGREG DGDGDGVCDL LLDTAHQDSL
KEFSQRADEH LHRHLPAYMC PKLYLPITHI PLTISGKINR RLLRHMASTL SQDQLTHLFR
GTGSDEKKRI IPPQTDSERI LRDLWARVLA IPAEKISTDD AFFRLGGDSL SAIKLASTSR
DSGLILSVRD VFLHPILSAL ATNVLPVHPS PSPENSLSPF TLRPPTLTPE TTKSLAASAC
GVPVETIQNV FPCTPLQAGM VALSLRFPGE YVVCYALELN AEISEGRWRR AWEESVRAIP
SLRTRIAQIG EGGLFQIVVD AALSWEEIDS SSLEGYISRE KGRGMGLGAP LARFALLKTQ
TPEELEERRV FVLTIHHGVF DGWSLPLILE VVASCYRGSS VLPRTVGHDS FVQFLAHTPE
SEAREFWRGY FEGLDFSTFP TISKDPQGSV QPGEVQDFCV FEGTGSLSSI TVATLVKAAW
ALVVGRNTAS HDIVFGCTVS GRNVPLPGIE RVAGPTVATV PLRVRLPDDA MRIEDFLSTL
QRDGATMMPY EQTGLVKIAT YSAEAQTACT FQTLLIIQPD DAQEKMQMRP FGRWVPDHGA
ASSRTYPLVL KIQLAEDRVK ILATFDPRAM REEDARRLLR QLVLVLSQLR NAGPETTFQR
IVSTPLEDER RIRECNAQAP ASVDACVHHL IADQARARPN AVAVCSWDGT LTYGQLHAAS
ERFARRLCRL SPCSKAVVAL CFQKSKWTSI AALAVMKAGG ASVALDTALP AGRLRTIVDQ
VRPPYILCSE ATEPLARMVG GGYAIVRIDR DGNDQEPLPP PLPTPSPADP LYVVFTSGST
GVPKGVIITH SNFATAAALQ HRKLHLDTTS RVLDGVSYAF DVAWSNMLHC WLAGACLCIP
NTDELGNDMV SAITRLSVTY AHLTPSLARM LDPRRVPSLR VLSFIGEPLN AADLARWKGT
GVTLLNTYGP AECTVVSTIT DPLPTDMEDD PSIGSAVGLN AWIVEPTHGQ YLVPIGAIGE
LVLEGPLVGA GYLHDADKTR AVFLEYPEWL GRSSRLYRTG DLVRSSPEDP RILTFVGRKD
GQVKIRGQRV ELGEVEHHVE MAVRKTLAFQ DVRVAAALIT PRDMVERSVL AAFLVWSGAE
GEGLSSSNQV LKAEATQAVN DHLAQQVPSS MIPVAYIRVE SIPLEATGKV SRRRLKEIGS
QVSVCEDTAD EKAPEEAAQP STALERELQA IFARTLKRSA ESIGVRSDFF QMGGDSITAI
QVVAACRARG FGEGVSVQDV FQRRNIAELA VLLEERCKAT QDDARVVEEM PGRGRGHDVN
DDRRRFRLSL DDDASVELKK KLGHMGLDVS QVEEVYACAP TQEAMLLQQA VAPDMYRLRL
EFDVLPSSAE LPAVNVVRLQ RAWRTVVKRH AILRTVFVES ERGFVQVVLR NCSPDVVCVR
ASPPPPPSNA SPPTHAPAQP QHRVEIRQSA DASTPVKFIL SINHALMDAH SIGLLVRELT
AIYSALPLDH DVVVPYAKFI EFLAHQSLAE ARSYWASRLQ GVEACCIAST ASASSSSSSS
TVAIPPIAHA PLKLFCATFG VSVSSICQVA WALVLRAFTA SRTPCFGVVI SGRELPIDGV
QSIVGPLVTT VPFVVPLDDD SLVLETVRRS FDDTLHAVRH QLLPLMEMQH TNTGALFDSA
LSVTTEHAHD TDVDADADDA DDADVVFRSV GGHDVSEFAI AAHVVAGHES TRASLNYAST
IPDDLALSIA AAFSEAISSL TAITLDAHSA LIGNVNLVSA HDVDMIRQWN AITPQPAHPP
QCLHERVSEC AAKWPEALAV CSWDAELTYH ELDQRSTRLA HSLVHRGVGA DVRLPFCIEK
SAAAVVAILA ILKAGATFVP LDPQWPAARY KDILARTDAP FVLTSRQCQH HLVANGAPTV
LLDESPHSPR LPLPQCDPNA AAYVLFTSGS TGAPKGVVVE HSAVCTSCLA LGPALCFNRE
SRVLQFSAFV FDGCLMEIFT TLLYGGCVCV PSDAERANDL EAFMNRRRVN YAFLTPSRTR
LLNFSRLQSP LETLLVGGEP VANADCDVWS REVNRLLIVY GPTEACIICF VAHYPSPSER
EKGKKAVQGT IGRAILPSSR SWIVDATNFT RLCPIGATGE LLIEGPVLAR AYLGDEAATN
ASFVHALQNT LGAETRLYRT GDLVKYERDG TVTFVGRMDG QVKVNGQRIE VGEIEQHVRQ
CLPNAAVVVE HVHVRGRSSA LLAAFIQVGE ADTELVAIRR DQITSFAREL PQQLRARLPI
AMVPKLYIPV TKVPLTVNGK VDRRSLRHLL SALAEEDLAD LHGIDRDHAL HQRPSGATEQ
LLSNLWAKVL GCEERLLSRH DHFLQLGGDS LTALKLSSEA RKHHLSLAVS DILRHPILSD
MAHAAGSVTE EHAEPSYISP FALLPAGASK AQMQRLASIA CELSSESIED VYPCTPLQEG
MLALSTSSQG DYLACYVLAL RDTIDLERFK MAWHATIHSI PILRTRIAQL GHLGLFQIVQ
DRMELNWTES TSLQEYVRHK KATPPGLGQR LLDVAIVVEE KRRFFVWTIH HALFDGWSLP
LILDVVEDHY GNGRNLRPMA AFNAFIAHLC RVQDEDAAAE FWRSLLAGFD SSHFPSQVPN
MLTTNDDGGR GNAERFCSLG SIAKSDFTIS SVLRAAWALV VARYTASRDI VFGCTVYGRS
APVADINHIL GPTIATVPVR VQVNDNASIS EFLRQIQNQT TAMIQYEQVG LRKVRSLGAD
AEHACQFQTL LVIQPKAERI SHDAHSDDDD SPFGNWQYQG QAQILTYPLM LQCEPTADGV
RLSAAYDRRV LSSSDTDGLL DSLAHVLTQL VEGSLSTIDD IEVVTPGQLD RIWSWNAPVP
TSCEQCVHDL VLSRGDTAPA IDAWDGQLSY AQLDDVSSRL ASRLQTLDLT YERLDSLSNR
VASRLHQHLD ISDTYVPICL EKSLWAPVAM LAVLKSGRAF VPLDPKLPPA RCESILQQVR
ATCILTSSTC ARRLLSLPTS ITTILVDREE KETVSDGVSA TLTSSSPAYI IFTSGSTGQP
KGVVMEHGAV STSCLAHGNA LGFATPGRRV LQFSSYVFDG CIMEIFTTLI FGGCICIPSE
SDRGDYDCLA TFLREKGVNW AFLTPSVARC LSFGQLSGLD VLVVGGEVVT ESDRQIWRKL
KRFMVVYGPT EACVICMRAD YADGKHDRAS IGRAIEQGWR SWVVNSGDRL LPIGAVGELL
IEGPPLARGY LGAEDKTQAA FIESPDWLPN ARLYRTGDLV RYTNDGGLNF VGRRDEQVKI
NGQRLELAEI ELQLAECLAL AEAVIVELVE LRGQAPAVLV AFVQHTVVAA EGVVTLDETR
IPTMASMMGE LEVQLRDRLP TYMLPKLYVP LTRIPLTTSG KADRRLLRQL GSDLTAQQIS
LLRSHPHRTP PSTRTERLLA DLWAQVLKID DEAEISIHDD FFQSGGDSIS VMKFVGLARG
KGLYLDVRDV FANPTIHLLS PIVEN
//
