ID M3ATD1_STRMB Unreviewed; 443 AA.
AC M3ATD1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
GN ORFNames=H340_29439 {ECO:0000313|EMBL:EME96847.1};
OS Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1223523 {ECO:0000313|EMBL:EME96847.1, ECO:0000313|Proteomes:UP000011740};
RN [1] {ECO:0000313|EMBL:EME96847.1, ECO:0000313|Proteomes:UP000011740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40847 {ECO:0000313|EMBL:EME96847.1,
RC ECO:0000313|Proteomes:UP000011740};
RX PubMed=23558536;
RA Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT Transglutaminase.";
RL Genome Announc. 1:E0014313-E0014313(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EME96847.1}.
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DR EMBL; AORZ01000165; EME96847.1; -; Genomic_DNA.
DR RefSeq; WP_004954199.1; NZ_CP072827.1.
DR AlphaFoldDB; M3ATD1; -.
DR STRING; 1223523.H340_29439; -.
DR PATRIC; fig|1223523.3.peg.5976; -.
DR eggNOG; COG1169; Bacteria.
DR Proteomes; UP000011740; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF2; ISOCHORISMATE SYNTHASE ENTC; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235}.
FT DOMAIN 175..431
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 46671 MW; 3366A71D47CAFD6F CRC64;
MTTVQHVTAP PPNEPAGRAG ATGAISASPT SRTPSAPPTP LASPKTSRND AERRGAVEAV
GAATELLHAY DPHDTRFFAS PTRTLLARGV RAEVPHGDAP LARRVAETLE TQRRAGHPTP
LVIGSVPFDR SAPAALAVPE TVRTAPSPAA DPLMALPAVP PPAAEWDVRP EPAPAGYAAA
VAEAVRRMKD GEFGKVVLSR TLRLTSSRDL DLPALLDRLA RRDPTGYTFA VPSGPGRTLL
GASPELLVSK RGGRIVTNPL AGSTPRSADL AEDVRRAAAL LESEKDLHEH AMVVDAIRDA
LAPYCRSLDV PERPTLVRTA TMWHLSTTLR AEPADPSVSA LELACALHPT PAVCGTPTDT
ARRVIGELEP FDRGAFTGMV GWGDADGDGE WVVTIRCAEA EPAARRLRLY AGAGVVEQSD
PEAETAETGA KFRTFLQAVG VDQ
//
