ID M3C1J2_9ACTN Unreviewed; 125 AA.
AC M3C1J2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=S-adenosyl-L-homocysteine hydrolase {ECO:0000313|EMBL:EMF30164.1};
DE EC=3.3.1.1 {ECO:0000313|EMBL:EMF30164.1};
DE Flags: Fragment;
GN ORFNames=H114_04958 {ECO:0000313|EMBL:EMF30164.1};
OS Streptomyces gancidicus BKS 13-15.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces pseudogriseolus group.
OX NCBI_TaxID=1284664 {ECO:0000313|EMBL:EMF30164.1, ECO:0000313|Proteomes:UP000011732};
RN [1] {ECO:0000313|EMBL:EMF30164.1, ECO:0000313|Proteomes:UP000011732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BKS 13-15 {ECO:0000313|EMBL:EMF30164.1,
RC ECO:0000313|Proteomes:UP000011732};
RX PubMed=23599292;
RA Kumar S., Kaur N., Singh N.K., Raghava G.P., Mayilraj S.;
RT "Draft Genome Sequence of Streptomyces gancidicus Strain BKS 13-15.";
RL Genome Announc. 1:E00150-13(2013).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF30164.1}.
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DR EMBL; AOHP01000037; EMF30164.1; -; Genomic_DNA.
DR AlphaFoldDB; M3C1J2; -.
DR PATRIC; fig|1284664.3.peg.978; -.
DR Proteomes; UP000011732; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EMF30164.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011732}.
FT DOMAIN 8..45
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF00670"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMF30164.1"
SQ SEQUENCE 125 AA; 13847 MW; 1B7F9822B9C079A9 CRC64;
AGLAKVPGIV KDEIKPQVHT WTFPDGRKII VLSEGRLLNL GNATGHPSFV MSNSFADQTL
AQIELFTRPE AYPAGVHVLP KHLDERVARL HLDALGVKLT ALRPEQADYI GVPVEGPYKP
DHYRY
//
