ID M3C3K4_STRMB Unreviewed; 819 AA.
AC M3C3K4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=H340_20866 {ECO:0000313|EMBL:EME98536.1};
OS Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1223523 {ECO:0000313|EMBL:EME98536.1, ECO:0000313|Proteomes:UP000011740};
RN [1] {ECO:0000313|EMBL:EME98536.1, ECO:0000313|Proteomes:UP000011740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40847 {ECO:0000313|EMBL:EME98536.1,
RC ECO:0000313|Proteomes:UP000011740};
RX PubMed=23558536;
RA Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT Transglutaminase.";
RL Genome Announc. 1:E0014313-E0014313(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EME98536.1}.
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DR EMBL; AORZ01000074; EME98536.1; -; Genomic_DNA.
DR RefSeq; WP_004949033.1; NZ_CP072827.1.
DR AlphaFoldDB; M3C3K4; -.
DR STRING; 1223523.H340_20866; -.
DR PATRIC; fig|1223523.3.peg.4248; -.
DR eggNOG; COG0188; Bacteria.
DR Proteomes; UP000011740; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EME98536.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 21..476
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT REGION 785..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 819 AA; 87880 MW; 90CBF752D4AB37F8 CRC64;
MARRSTKTPP PEEFEERILD IDVVDEMQGS FLEYAYSVIY SRALPDARDG LKPVQRRILF
QMNEMGLRPE RGYVKCARVV GEVMGKLHPH GDASIYDALV RMAQPFSMRV PLVDGHGNFG
SLGNDDPPAA MRYTEARMAS ATSLMTESID EDTVDFAANY DGSEQEPVAL PAAYPNLLVN
GTTGIAVGMA TNMPPHNLGE VIAAARHLIR HPNADLDTLM KYVPGPDLPT GGRIVGLNGI
RDAYETGRGT FKIRATVSVE NVTARRKGLV VTELPFAVGP EKVISKIKDL VGAKKLQGIA
DVKDLTDRAH GLRLVIEIKN GFNPEAVLEQ LYKLTPMEES FGINNVALVD GQPLTLGLKE
LLEVYVDHRF EVVRRRSEFR RGKRRDRLHL VEGLLVALVD IDEVIRIIRS SDNAAAAKAS
LVERFSLSEV QTQYILDTPL RRLTKFDRIE LEDERTKLTS EIEELTKILE SDAELRKLVS
SELADVAKKF GTDRRTVLLE SAGAPASAVP LQVADDPCRV LLSSTGLLAR TATGEPFAPG
AGETKRVKHD VIVSAVPATA LGEVGVVTSA GRLLRLRVID LPQLPETAAA PNLAGGAPLS
EFLSLADDER VVCLTTLDES SPGLAIGTEQ GVVKRVVPDY PANKDELEVI SLKAGDRVVG
AAELRTGDED LVFITDDAQL LRYQAGQVRP QGRPAGGMAG VKLSSGAKVI SFTAVDPAED
AVVFTVAGAA GGLPGAASEG TAKLTPFDQY PRKGRATGGV RCQRFLKGED CLVLAWAGAA
PARAATANGT PAVLPEPDPR RDGSGTPLAK PVAVVAGPV
//
