ID M3CC61_STRMB Unreviewed; 325 AA.
AC M3CC61;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:EMF01576.1};
GN ORFNames=H340_05194 {ECO:0000313|EMBL:EMF01576.1};
OS Streptomyces mobaraensis NBRC 13819 = DSM 40847.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1223523 {ECO:0000313|EMBL:EMF01576.1, ECO:0000313|Proteomes:UP000011740};
RN [1] {ECO:0000313|EMBL:EMF01576.1, ECO:0000313|Proteomes:UP000011740}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40847 {ECO:0000313|EMBL:EMF01576.1,
RC ECO:0000313|Proteomes:UP000011740};
RX PubMed=23558536;
RA Yang H., He T., Wu W., Zhu W., Lu B., Sun W.;
RT "Whole-Genome Shotgun Assembly and Analysis of the Genome of Streptomyces
RT mobaraensis DSM 40847, a Strain for Industrial Production of Microbial
RT Transglutaminase.";
RL Genome Announc. 1:E0014313-E0014313(2013).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF01576.1}.
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DR EMBL; AORZ01000009; EMF01576.1; -; Genomic_DNA.
DR AlphaFoldDB; M3CC61; -.
DR STRING; 1223523.H340_05194; -.
DR PATRIC; fig|1223523.3.peg.1055; -.
DR eggNOG; COG1071; Bacteria.
DR Proteomes; UP000011740; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:EMF01576.1}.
FT DOMAIN 13..305
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 325 AA; 34296 MW; 7E7B71CCCB4D46DE CRC64;
MGAESRAVRL YRTMRLIREF EERCLAMSLT GEIVGGIHPY IGQEAVAAGV CAALTKDDVV
ASTHRGHGHV LAKGADPKRM LAELLGTTDG LNRGRGGSMH AADVGLGVYG ANGIVGAGAP
IAAGAAWSFQ QRGEDRVAVA FFGDGALSQG VVLEAFNLAA LWRLPVVFVC ENNGYATSLP
VGRALAGDPV ERAAAFGLAA RAVDGMDAEA VADAAAQAVE RCRAGGGPAY LECRTYRFHG
HHSYEEQVAL NYRDDAEVGD WRARDPLRTQ STRVDAATVR TVDAEITALI DEAVEFARAG
RAPEPHEALD HLYADGTTTR PGVMI
//
