ID M3D3F7_SPHMS Unreviewed; 2502 AA.
AC M3D3F7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Histidine kinase HHK1p {ECO:0008006|Google:ProtNLM};
GN ORFNames=SEPMUDRAFT_133173 {ECO:0000313|EMBL:EMF12419.1};
OS Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria
OS musiva).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Sphaerulina.
OX NCBI_TaxID=692275 {ECO:0000313|EMBL:EMF12419.1, ECO:0000313|Proteomes:UP000016931};
RN [1] {ECO:0000313|EMBL:EMF12419.1, ECO:0000313|Proteomes:UP000016931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SO2202 {ECO:0000313|EMBL:EMF12419.1,
RC ECO:0000313|Proteomes:UP000016931};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
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DR EMBL; KB456264; EMF12419.1; -; Genomic_DNA.
DR RefSeq; XP_016760540.1; XM_016902548.1.
DR STRING; 692275.M3D3F7; -.
DR GeneID; 27899685; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_001037_0_0_1; -.
DR OMA; QLPGYTW; -.
DR OrthoDB; 1222064at2759; -.
DR Proteomes; UP000016931; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43047:SF46; HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000016931};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 65..386
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1914..2136
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2187..2310
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 82..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1640..1672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2334..2502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1873..1910
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 83..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1670
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2340..2370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2412..2438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2442..2459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2241
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2502 AA; 277351 MW; 4D2A80A0DFA64BF4 CRC64;
MLQSLAGNMD LVVEDEADRV GEDEADRVVE DEAQVASIRR FFERLREDVP GYEFSDEVPP
FHSSYDNWHF FGRKKNAKAT AAGAASRKSS LSAVTDSRPP SVRTRSDYDA ATPDEEQEQP
IWVVGRLSKQ ILRLEREFKL CQQLFQTAED HKHFVRPISL LRLPARQPGD VPLCISIVEA
PGKDYLQDLV NLGSDFYGGV PGSQQIQHRE QVPLLTFLDF AIGASECLEI LHHGSDIVHG
EIRGDAFHYN KDTGTVRMIN FGSGVRSFEH GLTSANWTTL MSQRGVEHRL QFIAPEQTGR
LPAEPDARTD IYSLGILFWT MLTGQPPFEG KSPLDVMQNV LGRRIPLASS IRTDVPDVLS
RLIQKMTARN MDDRYNSTTG VKHDLQKLKK ILTDGDQEAL ASFKLAEKDV SCFFVLPSNL
VGREEQRAKI IEVIERAAAK AARSTLSRKA LYSLSSTGSS VISSDPQIAN LLDDISDSTS
STDRERTDNH LTSIPEAIPS EQRMYRTSLD YPDRTARTGS TVSPAASINE DGGLTSQGYK
DTSYDSHGSG TSGNREGSES LFRTMSSYQL GSMTSEPSSL LRTAQKIKRK GRTEIISICG
QAGFGKSALV QSVQVRARKY GYFATAKFDP VRKAPFDPVV RVMSSLFRQI FSENDVSTPF
HENVRTFVKP YWGILHTYLD LPVWLLAPTI NGKMAASQGP SEMRSAHGQL ERPPERKTCN
AASTQEWLRS GGSSKSSRFM SIFLDVLRLL AVQKFACFCL DDIQFADPES LELLQIIVKS
HIPLVLMLTY REEKPITPAV AKLLEKATRV DVGPFSDNQL TEYVSQTLHR PAEYVTPLVA
IIHEKTQGSP FFVREMLDSA YRKKCIYYCW KCGHWEFSLD RLFAEFSTPD AGKFSTDDFI
LRRMKELAID AQTVLAWAAI IGNSFSFKVV RRLMSCACSE LSPQPLIPPQ SKDAVAGLQT
ALASFVVMPT DDEDRFKFSH DRYIAAADSL CKDYVREEMH YVVASSMMKH SPYDPVSQPS
VVLFEQARHI CKGVDAIKLR VPVKTAYREL LYQAAETARE SGARTSSLYY FKVCLDILPE
NPWADKTGDA SYSETLSLHI RAAEALGYAG DHETASKLLT AVFEHALNAT DKAPAAIILG
RMHVQKGDSK MAFDVLKRAL ADLGLSIEEK SLEECDEEFQ SLLPRLKENP PDFTGVDPKD
IDRSLSTLAA LLTEIQLAAF WTDHVLYYNV TLAILKVYLE RGMFSAVALG YVNMAAIIIW
RFSMIDIAME LGSHACQVLE FFDQEQYTIG RVLTLYAAFL GHMQFDFAGN FKFLNRALDA
ASSAGDKIAH LLNIGTSAAY RLWASENLAE TEAYIISVGD EFPDWQENLR GGVFLVSTRQ
MVRALAGKTN YKSASEVLSD CSHSSNDYIK FIKAKASNPE RPLSIYMAHQ LQALYRFGYY
HEAVVLGERL LPMTDGLMCM RYRYSVMFYH ALAMIACIRE NPVRPDREEL MAKVMHYRAL
IEIMAAINNA NYVTHLSLLN AEIADIQQDY DHVLTHYEKA VDHALVSNVT LDEALALEQY
ADWLVRRGSA RPGRGIILDA ISAYRRVGAF GKADHVKDKY EYLLYGTRSL SNVDTGTQTV
NDASTSAPYA YKLERIASHQ ASQTPADRTE EWLEPTSGQS RLTSSIRDSM NREPPAALSS
AVGLDMIDLA GILESSQLLS SELNVDRLLS KLTDIIVDSA GAELVGLVVE NDQGEWCVAS
VGTPDDIEAP AMGIPLAEIQ DPVAKQVTMY VLRFKEEVFL RQVLDDERFS NVPDSWLEQN
PDGASMVSIP ILHGENVLLG SLYCQAPPNT FTERTVTLLK LLVNQIAISI ANALLFKRAE
RVQASNASML IVQKQALAQA QEQEKKAKAA EAEAKEMVRL KDEAAKAKSM FLANVSHELR
TPLNGVIGMS EMLKATPLNR EQEEHADSIR VCADTLLSVI NDILDFSKLE AGKMQVFSVP
LSLTETITEV VRALSYTNIE RNLVTKTELH LDKELVVMGD PVRLHQILMN LMSNAYKFTA
RGTVTVHAKV DREDAESITV TTSVQDTGIG ITEEQQKKLF LPFSQADSST ARSYGGTGLG
LSICKAILEN VMKGQIWLES TPNVGTKVSF RLSFKKVNAS DLHEQSGTAP HGREADPMAI
FTPPAADDGP GARAVVSLQG IPRDQLKVCI AEDNPINQKI AINFVKKLGF SCEAYGDGQQ
AVDALTRASE DNRPFHLVLM DVQMPVLDGY NATREIRKHP DPRVRDILVI AMTASAIRGD
REKCLEAGMN NYLAKPVRAD TLKQMLESYL HQPRKDMPNL QDEANRLVEN VENEEARQQH
HLQQQQQQQQ NASRNGKENA KSNNATAGTG GIGSRLPELT KSGDLRRQAP QRPRSAQRAT
AIHLSPEEMI PKPKASSSSS SSGSSSSSTS STRAGQDPSM KEQLKLVDRQ IKELRDRPSR
AGSVSPAPPL KDRSGSGGEN AKRGSTDGRK DGVEGGGEDG GQ
//
