ID M3D9N9_SPHMS Unreviewed; 788 AA.
AC M3D9N9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Isochorismatase hydrolase {ECO:0000313|EMBL:EMF14589.1};
GN ORFNames=SEPMUDRAFT_132215 {ECO:0000313|EMBL:EMF14589.1};
OS Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria
OS musiva).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Sphaerulina.
OX NCBI_TaxID=692275 {ECO:0000313|EMBL:EMF14589.1, ECO:0000313|Proteomes:UP000016931};
RN [1] {ECO:0000313|EMBL:EMF14589.1, ECO:0000313|Proteomes:UP000016931}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SO2202 {ECO:0000313|EMBL:EMF14589.1,
RC ECO:0000313|Proteomes:UP000016931};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; KB456262; EMF14589.1; -; Genomic_DNA.
DR RefSeq; XP_016762710.1; XM_016902482.1.
DR AlphaFoldDB; M3D9N9; -.
DR STRING; 692275.M3D9N9; -.
DR GeneID; 27899619; -.
DR eggNOG; ENOG502QRZN; Eukaryota.
DR HOGENOM; CLU_005335_0_0_1; -.
DR OMA; KMYHLSG; -.
DR OrthoDB; 1644896at2759; -.
DR Proteomes; UP000016931; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006307; P:DNA dealkylation involved in DNA repair; IEA:InterPro.
DR GO; GO:0035552; P:oxidative single-stranded DNA demethylation; IEA:InterPro.
DR CDD; cd00431; cysteine_hydrolases; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR032854; ALKBH3.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR PANTHER; PTHR31212; ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3; 1.
DR PANTHER; PTHR31212:SF5; ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500); 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EMF14589.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016931}.
FT DOMAIN 600..719
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 276..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..300
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87073 MW; 14D690AD72A7BE8C CRC64;
MSFLSALLSQ QTPNLQTRKG LIVVGLQNDF ILPDGKLPVK DAAFVNRIGS LVPAFREHGE
IIWVRSEFQQ TRPVNGDDTP GDRVIAAGSL GTGLDRQRSG DVPAANKKYK FSASFEKPEA
GKEEGDDEEL FLSRTSKREP CCIKGSHGAD FSDRIKPLIQ RKDLQVVKSH YSAFAGTSLL
MTLRSKLITD VYICGCMTNL SVYATAMDAA RYGIEITLVE DCLGYRRFDR HQMAVQQLNH
FMSANFWKSA RVLAQLLDPS LEFPSSDSGA IEVVVEEEDD DDDDDDDDED EDEEEQTEEQ
QHKGEEEKQE KEATEGSTVM GDRRSTLLQA QADVLEVDSD EHSDEEVSLP TVGLPRRLLD
RISERSFATR LSSKYSPRAA RRPRITTTQY ATPESPRSDP RHNDPGHESE KGAIEFGKLK
FATASGHSRL ISTHSGSSRQ VSRLPWLDII PPNYKSSQDI GPPASSHQQG SPCAPSQSTA
SPPSSGGKKP KAMSTCSQKS RPLFGEDKVA ESAGSRILHG LLPEDAAETA FEDVQSEVKW
QSMFHQTGPV PRLVSCQATI CDDGSVPLYR HPSDQTPEVH AWTPTVDRIR KAAEQVAGHR
LNHALIQLYR DGNDFISEHS DKTLDIAPDS NIVNVSMGAQ RTMRIRTKRG AGTGSGNTAE
ARTTYRVPLP HNSMVTMSLQ TNAEYLHAIP WDRRPPCELV EAEKAFGGQR ISLTFRCIAT
FLSQDRTMIW GQGAVGKSKD TARRVVHGDP EESQKLVDAF GKENAASSIE WKEIYGSGSD
VLHLKQQQ
//
