ID M3DGL6_9ACTN Unreviewed; 428 AA.
AC M3DGL6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=H114_10011 {ECO:0000313|EMBL:EMF29100.1};
OS Streptomyces gancidicus BKS 13-15.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces pseudogriseolus group.
OX NCBI_TaxID=1284664 {ECO:0000313|EMBL:EMF29100.1, ECO:0000313|Proteomes:UP000011732};
RN [1] {ECO:0000313|EMBL:EMF29100.1, ECO:0000313|Proteomes:UP000011732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BKS 13-15 {ECO:0000313|EMBL:EMF29100.1,
RC ECO:0000313|Proteomes:UP000011732};
RX PubMed=23599292;
RA Kumar S., Kaur N., Singh N.K., Raghava G.P., Mayilraj S.;
RT "Draft Genome Sequence of Streptomyces gancidicus Strain BKS 13-15.";
RL Genome Announc. 1:E00150-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF29100.1}.
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DR EMBL; AOHP01000052; EMF29100.1; -; Genomic_DNA.
DR RefSeq; WP_006131547.1; NZ_AOHP01000052.1.
DR AlphaFoldDB; M3DGL6; -.
DR PATRIC; fig|1284664.3.peg.2006; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000011732; Unassembled WGS sequence.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:EMF29100.1};
KW Oxidoreductase {ECO:0000313|EMBL:EMF29100.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011732}.
SQ SEQUENCE 428 AA; 48300 MW; 880F267AA5486887 CRC64;
MTALADTTVH DFVAIGLGPF NLGLACLTEP IDELDGVFLE SKPDFEWHAG MFLDGAHLQT
PFMSDLVTLA DPTSPYSFLN YLKEKGRLYS FYIRENFYPL RVEYDDYCRW AAAQLGSVRF
GTTVTEVTWD ETAEVYVVAT DTGATYRGRH LVLGTGTVPY VPEPCRGLEG GLFHNARYTR
RKAELLTKKS VTIVGSGQSA AEIYYELLSE IDAHGYQLNW VTRSPRFFPL EYTKLTLEMT
SPDYIDYFRA LPEDTRYRLE KQQKGLFKGI NSDLIDAIFD LLYQKNVESG GRGVPTRLLT
NSSLTSARYE DGTYTLGFRQ DEQGKDFEIA TEGLVLATGY HYEQPAFLEP VRDRLRFDSH
GRFDVARNYA IDVTGRGVFL QNAGVHTHSI TSPDLGMGAY RNASIIRELL GAEYYPVEKS
IAFQEFAV
//
