ID M3DLU1_9ACTN Unreviewed; 336 AA.
AC M3DLU1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Hydroxyneurosporene-O-methyltransferase {ECO:0000313|EMBL:EMF30950.1};
GN ORFNames=H114_01323 {ECO:0000313|EMBL:EMF30950.1};
OS Streptomyces gancidicus BKS 13-15.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces pseudogriseolus group.
OX NCBI_TaxID=1284664 {ECO:0000313|EMBL:EMF30950.1, ECO:0000313|Proteomes:UP000011732};
RN [1] {ECO:0000313|EMBL:EMF30950.1, ECO:0000313|Proteomes:UP000011732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BKS 13-15 {ECO:0000313|EMBL:EMF30950.1,
RC ECO:0000313|Proteomes:UP000011732};
RX PubMed=23599292;
RA Kumar S., Kaur N., Singh N.K., Raghava G.P., Mayilraj S.;
RT "Draft Genome Sequence of Streptomyces gancidicus Strain BKS 13-15.";
RL Genome Announc. 1:E00150-13(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF30950.1}.
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DR EMBL; AOHP01000007; EMF30950.1; -; Genomic_DNA.
DR AlphaFoldDB; M3DLU1; -.
DR PATRIC; fig|1284664.3.peg.268; -.
DR Proteomes; UP000011732; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EMF30950.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011732};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:EMF30950.1}.
FT DOMAIN 4..78
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 100..314
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 236
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 336 AA; 36084 MW; 8B9D42534564E4EF CRC64;
MRMLLYGQLV SKAVCTAVEL GLPEALAGGP RSAEELAGDV DAHPLALRRL LRALVPFDVF
TEAPDGTFTL TRLGATLLPD TPGTARPSAL LLAGEVGRTW QEFGYSVRTG DSAFTLLHDC
TLFEHLERRP ERREVFDRSQ EAGLRLELDE IFDAVSFDRY PTIVDVGGGN GHLMCELLHR
TPGSTGSVID LPGTVQLAEK RIVEGGLTDR CTAVVGDFFD SVTPGADLYI LSHILHDWGD
DSAVSILRTC AAAMPAHGRL MVIDLLTDAA ADDQGGRHRL PALMDLYMLS LFGAAGGQER
TGAEFTALLT AAGLEAEETR VLPSGMGVVT ARRRTT
//
