ID M3H3V9_9LEPT Unreviewed; 707 AA.
AC M3H3V9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:EMF83455.1};
GN ORFNames=LEP1GSC188_1169 {ECO:0000313|EMBL:EMF83455.1};
OS Leptospira weilii serovar Topaz str. LT2116.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1088540 {ECO:0000313|EMBL:EMF83455.1, ECO:0000313|Proteomes:UP000011770};
RN [1] {ECO:0000313|EMBL:EMF83455.1, ECO:0000313|Proteomes:UP000011770}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2116 {ECO:0000313|EMBL:EMF83455.1,
RC ECO:0000313|Proteomes:UP000011770};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Tulsiani S.M., Graham G.C., Burns M.-A.,
RA Dohnt M.F., Smythe L.D., McKay D.B., Craig S.B., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMF83455.1}.
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DR EMBL; AHOR02000012; EMF83455.1; -; Genomic_DNA.
DR AlphaFoldDB; M3H3V9; -.
DR Proteomes; UP000011770; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:EMF83455.1};
KW Cilium {ECO:0000313|EMBL:EMF83455.1};
KW Flagellum {ECO:0000313|EMBL:EMF83455.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000011770};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 35..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 60..77
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 282..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 707 AA; 77475 MW; 9BC16A3E162FB2E4 CRC64;
MEKKWWNQSD VILGVGAVAI VAMLVIPLPG FILDILIIVS LAVGLLVLLT SLSVNEPADF
SIFPSLLLIT TLYRLALNVS TTRQILSKGP AMNSHVIDAF GSFIIGSESG LSKYVVGFII
FIILVLVQIL VITKGATRIS EVAARFTLDA LPGKQMAIDM ELSSGNINEE EAKKRRKRIE
AEVDFYGSMD GASKFVQGDV RAGLIITAIN LLGGVIIGAS IRGESFTQAI ETYGKFTIGD
GLVSQIPALL TTVATGIIVT RSGSESDLAT QFKSQLFSNS KVLYVVAGSL GFSAFIPGLP
FIPLVLLSAG IAYLGYSLEQ TVKEQLESIE KKEKESGQDR KPKDFYEELR TDPIEIEVGY
HLIPLVDTSQ GGALLDQISN LRKKFAQDNG VVIPPVRILD NLDLNPDTYS IKINGTEVGT
STVKPDKLMA LNTSPGAAES IQGEDFLEPS FGQKAKWISS EDKSEVEAKG YTVVDASTVV
VTHLKELLAT HASTLLGREE VKKLLDHYKA SYPTLIGELD ADKPGNLGII QQVLQNLLRE
GLGIRNLVPI LESIANNLSK YQNPYILTEL VRQSVARTVV KDYLSMDGKL RVITLESKIL
DRLNKSITQD RIENRDILSL APDFYRKLID SVAELYRKFR IEGKFPIFVV NREVRLPFSY
LLAKEFPPRN FGVLAYEEIH SSVDSIIEAE LKLPQTQTAP AGVEEEA
//
