ID   M3HMX7_CANMX            Unreviewed;       627 AA.
AC   M3HMX7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Cation diffusion facilitator, putative {ECO:0000313|EMBL:EMG48817.1};
GN   ORFNames=G210_0567 {ECO:0000313|EMBL:EMG48817.1};
OS   Candida maltosa (strain Xu316) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG48817.1, ECO:0000313|Proteomes:UP000011777};
RN   [1] {ECO:0000313|EMBL:EMG48817.1, ECO:0000313|Proteomes:UP000011777}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA   Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT   "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT   for xylitol and ethanol production.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMG48817.1}.
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DR   EMBL; AOGT01000963; EMG48817.1; -; Genomic_DNA.
DR   AlphaFoldDB; M3HMX7; -.
DR   STRING; 1245528.M3HMX7; -.
DR   eggNOG; KOG1485; Eukaryota.
DR   HOGENOM; CLU_013430_10_0_1; -.
DR   OMA; KKPIREY; -.
DR   OrthoDB; 5479358at2759; -.
DR   Proteomes; UP000011777; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0098771; P:inorganic ion homeostasis; IEA:UniProt.
DR   GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:UniProt.
DR   Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR   Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   NCBIfam; TIGR01297; CDF; 1.
DR   PANTHER; PTHR43840:SF4; CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG); 1.
DR   PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR   SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011777};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        331..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        442..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          258..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..80
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  70473 MW;  0292B8C4E2FBA6F5 CRC64;
     MTKKDSTSNN EKSPLLKKTL KKSTTTGEYP GLLPPVNSNT SPANAFRHAQ YSTPHLQGGA
     NPSSSNNPLH PTSSGNGANV DDEYEYTEFD NYFNGKRHHS FGANDYSNRQ PADERPLFHR
     LLSSHHSVTN PNSPFDNYVS GGNLSSTQIN VPLFPQKTGG DRSSIGSVLE GGQYRRFSVV
     DIVGTVRPAR LLGSVKPLCK WTSFFNSDIE KIRKRDVRKY YEEQNYLIER FTEIDNFLDA
     GKIHYNMLSN YTEGERTLED VSEVSRESTS PINSQRMDTS NTDDSVIQAS DMERNDSTSK
     YSNRFHDIPG NVNHDGSRYL GYNEEENNAQ VLTAILVNFL INILLLIGKT VVTLLTSSMS
     VIASLVDSIL DFLSTFIIYI VNRLATQNNW KIQHAYPIGR SRLEPLGVLI FSIIIIISFF
     QVGQESFKRL FFASPDQKIP VAIGLDAISI MTITIVAKLG CWIWCASSKS SSVQALAQDA
     MTDVVFNSVS LLMPTIGHYF DIWWFDPLGA FGLSIYIIVN WGYTAFEHIN NLTGAAADPL
     DYKVILYLAY RFAEPIKQIT ALKVYHVGDN LNVEVDLVFA YEKYKLSFKD CHDIAEALQY
     SIESLPMVER AFVHIDYMEG NYKGHLK
//