ID M3HR68_CANMX Unreviewed; 1258 AA.
AC M3HR68;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=G210_5008 {ECO:0000313|EMBL:EMG50002.1};
OS Candida maltosa (strain Xu316) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG50002.1, ECO:0000313|Proteomes:UP000011777};
RN [1] {ECO:0000313|EMBL:EMG50002.1, ECO:0000313|Proteomes:UP000011777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT for xylitol and ethanol production.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG50002.1}.
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DR EMBL; AOGT01000418; EMG50002.1; -; Genomic_DNA.
DR AlphaFoldDB; M3HR68; -.
DR STRING; 1245528.M3HR68; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_0_1_1; -.
DR OMA; WWFDVES; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000011777; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011777};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1258
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004034566"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1097..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1122..1143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1195..1224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1236..1256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 575..743
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1258 AA; 141133 MW; F74A34AFBA832636 CRC64;
MRIINLFLLL LTHLTISLAS STHKQGYCNT YGNCGKKSVF GKPLPCATFE PAHRASQESI
DRLKAICGDD VNYEYVCCSD EQITDLETNL KRVDPLISSC PACRKNFYDF FCKFSCSPNE
SQFVEIVKSE MAKDTGKEIV TEINQFVDPA MAKSFFDSCK NVKFSATNGY AMDLIGGGAK
DYQQFLKFLG DEKPLLGGSP YQINFKYDIS KENQSAGLVL RDDGMKTCDD KDYKCACTDC
EASCPKLPHA RDLTEKCRVG VLPCFSFTVI VIWSCFIILL GGYHVYLAKA KKNGRISLMD
DDEDDDIVMD PNRYVGLGKH SAKKVSETLS VHIEYAFESI GKFCSHFPGV SIGGSLTVAV
LLSLGLFKLK LETDPVKLWV SPRDEAYKNQ QFFESNFGEW FRIEQVIVSS QNTSEPVLNW
DVFKWWFESE SQLETLNKNV SLSDICFKPL DETCAIQSFT QYFQGDLTGL NENNWKSKLQ
NCVDSPVNCL PSFQQPLKPN ILFDNNDISK AKAFTVTVLI NSDSQDKQYT ESVIAYEHSF
QKWASKLQAE FPHLNVAYST EISLTEELNQ SSNTDIRTIA ISYLLMFLYA SLALGGKLPH
AKLYSLVKTR FTLGFSGILI ILLSVTASVG FFSLVGLKST LIIAEVIPFL VLAIGIDNIF
LIVHELHLIT ELEPTSSIED RIAKSLKNIG PSCFISAILQ VSMFLLATSV SMPAVRNFAF
YGAGAVLINF LLQMTCFIGL LGLDQKRLEE NRVDCVPCIT VAPPTIQLAD DQTPTNEDQH
LEYNFSSWIG KYYAPFLLKR TTKPKVLTIF VLWVGISLSL FPGIKLGLDQ RIAIPSDSYL
VNYFNSVYEY LNVGPPVFYV VKDLDLKVRE NQQKICGKFS ACNEYSLANI LEQEFKRGDV
SMIAEPASNW LDDFLSWLNP DLDQCCRFKK NTVFTSGTPE FCSPYAPDRQ CQTCYLNHDP
PYDSSMKGFP EHEEFMFFFN DWIQEPSDPC PLGGKAAHGN SISRTNEVIK SSYFRSSFKP
LRGQDEFINA HKSGNNILKE IKKLIPSIDM FVYSPFFIFF TQYDNIIGLT ILLLITAMLI
ILVVGTILLG SLKAASILTL TNIFIMINIG GVLSLWSISL NAVTLVNLII CVGFAVEFTI
HLTRSFCFSK VKMFSNSTEE ELYNNLLNIE PENARSHGRR SSISSINANY KNSKAFNALC
TVGGSLISGV TITKIIGITV LAFTRSQIFE VYYFRMWLSL VLISFVHAFV LLPVLLSL
//