ID M3HTI1_LEPBO Unreviewed; 1099 AA.
AC M3HTI1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:EMG01366.1};
GN ORFNames=LEP1GSC123_3758 {ECO:0000313|EMBL:EMG01366.1};
OS Leptospira borgpetersenii str. 200701203.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193007 {ECO:0000313|EMBL:EMG01366.1, ECO:0000313|Proteomes:UP000011783};
RN [1] {ECO:0000313|EMBL:EMG01366.1, ECO:0000313|Proteomes:UP000011783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=200701203 {ECO:0000313|EMBL:EMG01366.1,
RC ECO:0000313|Proteomes:UP000011783};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Picardeau M., Werts C., Goarant C.,
RA Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG01366.1}.
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DR EMBL; AKWO02000028; EMG01366.1; -; Genomic_DNA.
DR AlphaFoldDB; M3HTI1; -.
DR BioCyc; LBOR1193007:G11KN-1602-MONOMER; -.
DR Proteomes; UP000011783; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR019793; Peroxidases_heam-ligand_BS.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS00435; PEROXIDASE_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011783};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1001..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1075..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 120507 MW; 0730840B4D819B1E CRC64;
MIDKLIRASI KNRALVLVLT FMITLVGIYN AYYLSIDAIP DVTNVQVSAV TSSPALSPLE
VEQFITYPIE MEFTGLPNVT EIRSISRAGV SSVTVVFKDG TDIYFARQLV NERIKQAEAI
IPPGYGRPEL SPIATGLGDI YEFVLTSDRH SPEELRTYMD WELAREVKSV EGIIDVNIIG
GQVRQYQVKI DPKRLAVHNL TLSQIYGKLE SANQNTGGGY ISKNSEQIVI RGESQYKSIE
DIKNTAVTTA GDGIPLLLGQ IAEVEIGPAL RFGLVTKDSK GEVVGATAMM LMGQNSLEVV
KKVKVRIQEI KERLPSGMRI ETFYDRSEFI GRTLGTIFTN LAEAAVLVVI VLILALGTVK
GALLVSLAIP IPMLVATIFM NAFGIVGNLM SLGALDFGLL VDGTIVMLES ILHGFILKRS
FYEMQTKLGD RELAAEEIIT DACVRVGRAA TFSVAIILLV YLPLMSLEGV EGRMFKPMAI
TVALALGAAL LFSLTTFPAA ASIIFKNPIF FHSKYWDIIT EKYKLLLNFG MSHKKEFCYA
GVGVVVFALL LASTLGSEFL PRIDEGEIAI DIKRLPSTSL NYSRDTNSDM EAVLKKFPEI
LGVVSRMGRG ESAAEPVGTD EGEAMVKLKP RKEWTTAEDR EELMTKMKDE ILKFIPSSTI
SLSQPIENRV NALLSGSKAD VVIKIYGDDL VKLKDIAGQF ANKLKSVPGV ADLRVQRVLG
LPLVEIKVDR ENMARYGVQA EEILATVEAL RLGRQTGKVF EGFKRFDLVV RLKIDATDLE
QVENIPVFTS SGSTVPLGQV AEIKLVEGPA AIYRESLKRR IMVETNIRGR DLVGFVNEAQ
KVTGEIEKNL PPGYRTDWGG QFENFTRAKE RLALVVPIAL AIIFFMLIAA FGSIYYALGV
FIVVPLAVSG GIIGLVIRGL PFSIPAGVGF IAVSGIAVLN GVVYASTLRE ELEKGASITD
AVYLAGIHSL RPVMTTEVIA AIGFIPMAIS TMAGAEVQRP LATVVIFGVI VATVFSRVLL
PIVMEYLLNL YESQERRKSA KRRLLEKRTF GNQGHSFAHD NSEWLEVHSE AQEIVTEEES
WETASKKKKV SKTKKGKKN
//