ID M3HTM6_CANMX Unreviewed; 1703 AA.
AC M3HTM6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=G210_5495 {ECO:0000313|EMBL:EMG50972.1};
OS Candida maltosa (strain Xu316) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG50972.1, ECO:0000313|Proteomes:UP000011777};
RN [1] {ECO:0000313|EMBL:EMG50972.1, ECO:0000313|Proteomes:UP000011777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT for xylitol and ethanol production.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG50972.1}.
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DR EMBL; AOGT01000055; EMG50972.1; -; Genomic_DNA.
DR STRING; 1245528.M3HTM6; -.
DR eggNOG; KOG3600; Eukaryota.
DR HOGENOM; CLU_242296_0_0_1; -.
DR OMA; FSRELWC; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000011777; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 2.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000011777};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 6..291
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1082..1264
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1280..1349
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT DOMAIN 1432..1688
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 334..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..462
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..722
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 192416 MW; 6813D2DE3CE79993 CRC64;
MTEAKASNIL THYYKLAHVG SITYTIYASS ENNDQALLEL ELTIRNKYPE ILITYYNKNL
YYFAFGHNLI NSDSPIDLST EFHQLSCKSS ESVTADQLAN PIKNHANNNE NLTYAGLSFL
KAVKKMILYN LSLNGSIRLF GNYCVSPNDD QSYSILCIDP VLFQNGDLLV SCLEKPNVRL
FSSMVAYPEE LAIETNFVIY LIPSGIRCHL FDPTNLRNNF IENPQVENEK LPEMLRLTTG
IDCDKSKLWV KLIPNLKHLN NQTSFVGKFI HSVDNKKFIL WPWDLCLLQF GKYEELQQEE
LSSASADYSN PMNLISDFLD FQITYNNQVQ QQKQTTLEQS LPLPSQQQQQ PQNQNQNQNQ
QQAIHGPFSV GSAQSTGIGS IGHIPDLPKD IGSIGLSATT PMDAELFNLQ NTEEFFKTTE
HNEIPIDQDQ AGERKGTKEE EETDNKSGDD MEIDDLFGGE DSDGDSSNEQ KDSAQISGEN
TGSGNSVSQD NSEQPPKDEL DDLFADDSSI ALEEKKDSSD DVVELEQLPK PKQEEDISKP
KDIKPSYIDI LKDQMMLKKS DSSPDYKDPG APLPIVPTPL VPPTIPQSTG ATNPPTVGPG
SVTDTIYDGA SIYNQSAPPS QMPQQKSVFS PILFNPIIKS DIDTKYGKGG KFYVDKDTAS
DTDFEKKKRS LRATSVSGME INFSSEDKKK LQQQLDAIES STTSESEYGD EEESDEDEEP
DMADLTPLKL NESSALPSYQ NPATSNIATI GPDFQNADKQ FLGNQSMNVE GFGSPFGNQM
SKFTMKPESP FMGNEMQTSM SPMYFDISQT QQSPQLQPSA ENSEVTKSTM LEAPSKISES
SNYLPLLLRN INVSSIPNWY LMNNLTSTKL LPTFSINDDD TESDLDITKS NELIVKLDHL
KEFLSFIAPN IVFDLGSNNF GELSYYFNNS AKIESSKELK LPNKSFLESL LKSFPYSYPV
KLAEFLHDTK ALEFEDQLDN QLNFLNDIPE DENFIDPKAL YKKLKSIEWD SFDCNHNNSA
NFEKYKETVE KLNTGNAPNE EDYFKLPIIK TKVMKNNNII NMNSIGLEFW KYLNFSPIKK
TKNFQILLIA ETHGNTSSYA SELLNQLVQN YRENNFGTIT KVNLSTVETR PDLEPINDGL
VLINKEQHQS FNDFYVQTNK KLISLVELIK LDLINKTNNF EFDRPLLLLF VNFNKSLNSN
LQICKIFRNF KVALMTHQLP LVEIFTKIVP SSLVAKKVGN ETSLKILSNY KLTKISMNLY
NECPNDVVNR STVKNIFTTI VKEPPSKIQF RFINNAYRDN SFNDDIFLHL AYERSVDKNW
FVASWSDPLG QVVHTKAWYC SNSPAQQHQQ QHSSSSQQQT PSHHQQQQQQ QHHNQQRQGY
RHDTMDIMSI SDDIWNISTE LFKFLNDEMN SNGGNTFGGK KFLVLTRVNS IIPDDELVHW
KRLSQKHKEI SLIVLSVCQT PKIVGSSELQ DFSSRASNFS PLPTNPEKDS FFNFKTAFST
SNNSSPASGG ALVTSPNGLS FHSPQQFLNA PANFLSPQDL MAPSSMGNTP SGTMNNELDS
DTILCSLKDD VYGVVSKLPL PSFNSPTRFC MKTGYLMKEV REDFPDDIKE EQDEQATKSK
SYLLYEINLL SCSNYWNLDV LMRLLMLQYK KMIVLNDVLC MNSLDGAKED IELSENYNAI
VPWHINAVGK LLNYLVHVYV DEE
//
