ID   M3J1X6_CANMX            Unreviewed;       438 AA.
AC   M3J1X6;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|RuleBase:RU364152};
DE   AltName: Full=Mediator complex subunit 20 {ECO:0000256|RuleBase:RU364152};
GN   Name=MED20 {ECO:0000256|RuleBase:RU364152};
GN   ORFNames=G210_3948 {ECO:0000313|EMBL:EMG45868.1};
OS   Candida maltosa (strain Xu316) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG45868.1, ECO:0000313|Proteomes:UP000011777};
RN   [1] {ECO:0000313|EMBL:EMG45868.1, ECO:0000313|Proteomes:UP000011777}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA   Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT   "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT   for xylitol and ethanol production.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       the regulated transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. {ECO:0000256|RuleBase:RU364152}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364152}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU364152}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC       {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMG45868.1}.
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DR   EMBL; AOGT01002303; EMG45868.1; -; Genomic_DNA.
DR   AlphaFoldDB; M3J1X6; -.
DR   STRING; 1245528.M3J1X6; -.
DR   eggNOG; ENOG502RDU8; Eukaryota.
DR   HOGENOM; CLU_625556_0_0_1; -.
DR   OrthoDB; 2787301at2759; -.
DR   Proteomes; UP000011777; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 3.30.310.180; -; 2.
DR   InterPro; IPR013921; Mediator_Med20.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   PANTHER; PTHR37273; CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR   PANTHER; PTHR37273:SF1; EXPRESSED PROTEIN; 1.
DR   Pfam; PF08612; Med20; 1.
DR   Pfam; PF13883; Pyrid_oxidase_2; 1.
DR   SUPFAM; SSF50475; FMN-binding split barrel; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU364152};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011777};
KW   Transcription {ECO:0000256|RuleBase:RU364152};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364152}.
SQ   SEQUENCE   438 AA;  48977 MW;  CA45026BCECF3052 CRC64;
     MVTVLLVQKA TPETIVQFHD QISNELPTIK GKWNFAFKIF KNNQYAIPQE LANTHTQAPE
     SKYLFTLSPS YLPDSTITLI NGKSAGVFTN LIEEEISELG HPTELSIPNE HLHRGATTGL
     NDKFDIFVGA KLQSLWTQRQ LVRGDGGQIY ELENGNLVIR TSNVFLHGNF RGLLIQIELS
     NSLVTPDDED SVKTKFKEIT TKYHFPEQRM LYLILLFALS LVNCVPVQDI IEIKDTPSVE
     EGASVARTLV NRESLANVNT IKSIKQADGS FSQLPVSNME YYADCDNDGD PYWLVIDVGT
     ANQNIIKGSK FSFSIRVGDH AKYDEVSDSY PGGIEGSPAG LPRVTLTGTL RQVYYPNPFD
     KRRIDLEKCF LKRHPDASMW LPGNYLSPHK SHWAKFTVDG VQLIGGFGDR AYIGEVDADL
     YHSAELIPPP EPEGRCLN
//