ID M3J4D0_CANMX Unreviewed; 678 AA.
AC M3J4D0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00013189};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189};
GN ORFNames=G210_2883 {ECO:0000313|EMBL:EMG46858.1};
OS Candida maltosa (strain Xu316) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=1245528 {ECO:0000313|EMBL:EMG46858.1, ECO:0000313|Proteomes:UP000011777};
RN [1] {ECO:0000313|EMBL:EMG46858.1, ECO:0000313|Proteomes:UP000011777}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xu316 {ECO:0000313|Proteomes:UP000011777};
RA Yu J., Wang Q., Geng X., Bao W., He P., Cai J.;
RT "Genome sequence of Candida maltosa Xu316, a potential industrial strain
RT for xylitol and ethanol production.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMG46858.1}.
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DR EMBL; AOGT01001852; EMG46858.1; -; Genomic_DNA.
DR AlphaFoldDB; M3J4D0; -.
DR STRING; 1245528.M3J4D0; -.
DR eggNOG; KOG1371; Eukaryota.
DR HOGENOM; CLU_007383_22_1_1; -.
DR OMA; KGLYREW; -.
DR OrthoDB; 5489993at2759; -.
DR Proteomes; UP000011777; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:InterPro.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000011777}.
FT DOMAIN 7..335
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 678 AA; 75775 MW; 44FFE820BBFC622A CRC64;
MSDEYILVTG GAGYIGSHTV IELINHGYKV VIADNLSNSS YDAVARIEFI VKQHVPFYKV
DIRNEKELNQ VFSNHKISGV IHFAALKAVG ESTKIPLEYY DNNVSGTIAL LNVCKSNNVK
TIVFSSSATV YGDVTRFGDN SMIPIPEHCP MDPTNPYGRT KFVIESILKD IYDSDELWKV
AILRYFNPIG AHPSGLLGED PLGIPNNLLP YLAQVAIGRR EKLSIFGNDY NSHDGTPIRD
YIHVVDLAKG HIAALAYLKN LQSKGLYREW NLGTGKGSTV FDVYHAFCRA VGKELPYEVV
ARRAGDVLDL TAKPDRANKE LNWKAELTVD DACKDLWKWT TENPYGFHID NYSWENFDGY
NNRLHSFVNG PLKVNLANHG ALIQKVLLDG VNMVKAYDNA ADFKDKSNPF FGTTVGRFAN
RVAKGQFELN GKKYQLTQNE GNNNLHAGFN GFDKQDFLGP VVKHKDGKFL VDFLIVDKDG
NDGFPGEVEA IVHYTIDESS VGIEYECRLL SGEATIVNMT NHSYFDVSDS ANIDGTEVKL
VTDQMMEVDA ELIPTGKFVA NEYVTDPIVL DEKKPFDNCF IVDDDNCGID TRARPLKKVF
EATHPKTNNK FTVETTEPAF QFYTGDGVNT KGFAKRCGFC VEPSRFIDAI NHEKWANQVI
LKKGEVYGSK IKYGFTKK
//
