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Database: UniProt
Entry: M3UWF7_9ACTN
LinkDB: M3UWF7_9ACTN
Original site: M3UWF7_9ACTN 
ID   M3UWF7_9ACTN            Unreviewed;       115 AA.
AC   M3UWF7;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Putative multidrug efflux transporter {ECO:0000313|EMBL:GAC85535.1};
GN   ORFNames=GP2_036_00360 {ECO:0000313|EMBL:GAC85535.1};
OS   Gordonia paraffinivorans NBRC 108238.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1223543 {ECO:0000313|EMBL:GAC85535.1, ECO:0000313|Proteomes:UP000035021};
RN   [1] {ECO:0000313|EMBL:GAC85535.1, ECO:0000313|Proteomes:UP000035021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 108238 {ECO:0000313|EMBL:GAC85535.1,
RC   ECO:0000313|Proteomes:UP000035021};
RA   Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Ando Y., Baba S., Ohji S.,
RA   Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia paraffinivorans NBRC 108238.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr
CC       subfamily. {ECO:0000256|ARBA:ARBA00007822}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAC85535.1}.
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DR   EMBL; BAOQ01000036; GAC85535.1; -; Genomic_DNA.
DR   RefSeq; WP_006901755.1; NZ_BAOQ01000036.1.
DR   AlphaFoldDB; M3UWF7; -.
DR   STRING; 1223543.GP2_036_00360; -.
DR   GeneID; 60748693; -.
DR   eggNOG; COG2076; Bacteria.
DR   OrthoDB; 3175079at2; -.
DR   Proteomes; UP000035021; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF1; MULTIDRUG TRANSPORTER EMRE; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   115 AA;  11674 MW;  8E06BF7D620197F7 CRC64;
     MPWILLIGAI ASEVAATLSL KGSQSHPALY AVVVLGYVVA FVLLSAVLRQ GMKVGVAYGV
     WAAAGVALTA VLSSVIFGEA FTPLMGIGIV CIMVGVLLVE SGSSTHAAVD IDETT
//
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