ID M3VU91_FELCA Unreviewed; 4544 AA.
AC M3VU91;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=LDL receptor related protein 1 {ECO:0000313|Ensembl:ENSFCAP00000000172.5};
GN Name=LRP1 {ECO:0000313|Ensembl:ENSFCAP00000000172.5,
GN ECO:0000313|VGNC:VGNC:68087};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000172.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000172.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000172.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000172.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000172.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000172.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000172.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDLR family.
CC {ECO:0000256|ARBA:ARBA00009939}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AANG04003655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003988980.1; XM_003988931.4.
DR PaxDb; 9685-ENSFCAP00000022607; -.
DR Ensembl; ENSFCAT00000000187.6; ENSFCAP00000000172.5; ENSFCAG00000000185.6.
DR GeneID; 101090780; -.
DR KEGG; fca:101090780; -.
DR CTD; 4035; -.
DR VGNC; VGNC:68087; LRP1.
DR GeneTree; ENSGT00940000157899; -.
DR HOGENOM; CLU_000085_2_1_1; -.
DR OrthoDB; 2876235at2759; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000000185; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 31.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 30.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 8.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR032485; LRP1-like_beta_prop.
DR PANTHER; PTHR22722:SF5; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B; 1.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 29.
DR Pfam; PF00058; Ldl_recept_b; 11.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 26.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00192; LDLa; 31.
DR SMART; SM00135; LY; 36.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 30.
DR SUPFAM; SSF63825; YWTD domain; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 16.
DR PROSITE; PS50068; LDLRA_2; 31.
DR PROSITE; PS51120; LDLRB; 25.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..4544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016401905"
FT TRANSMEM 4424..4444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 335..378
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 379..422
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 571..613
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 614..659
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 660..710
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 711..754
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1309..1355
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1356..1398
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1399..1445
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1446..1490
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1627..1669
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1670..1713
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1714..1753
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1934..1976
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1977..2019
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2020..2063
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2064..2107
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2344..2388
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 2389..2431
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 2982..3017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 3069..3113
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3114..3156
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3157..3200
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3201..3243
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 3970..4012
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 4013..4056
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 4196..4229
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4232..4268
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4269..4301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4304..4340
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4375..4409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 854..866
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 861..879
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 895..907
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 902..920
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 936..948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 943..961
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 984..1002
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 996..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1015..1027
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1022..1040
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1082..1097
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1125..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2532..2550
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2566..2578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2573..2591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2585..2600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2605..2617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2612..2630
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2624..2639
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2673..2688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2696..2708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2703..2721
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2715..2730
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2734..2746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2741..2759
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2818..2830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2825..2843
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2858..2870
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2912..2930
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2924..2939
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2986..2996
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3334..3346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3341..3359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3374..3386
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3381..3399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3393..3408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3433..3448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3536..3548
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3543..3561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3555..3570
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3575..3587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3582..3600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3594..3609
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3613..3625
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3620..3638
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3632..3647
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3654..3666
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3661..3679
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3716..3731
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3749..3767
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 3761..3776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 4200..4210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4236..4246
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4258..4267
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4272..4282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4308..4318
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4330..4339
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4377..4387
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4399..4408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4544 AA; 504666 MW; F2C89767E83F2EDB CRC64;
MLTPPLLLLL PLLSALVAAA IDAPKTCSPK QFACRDQITC ISKGWRCDGE RDCPDGSDEA
PEICPQSKAQ RCQPNEHNCL GTEMCILMSR LCNGVQDCVD GSDEGPHCRE LQGQCSQLGC
QHHCVPTLNG PTCYCNNSFQ LQADGKTCKD FDECSVYGTC SQLCTNTDGS FTCGCVEGYL
LQPDNRSCKA KNEPVDRPPV LLIANSQNIL ATYLSGAQVS TITPTSTRQT TAMDFSYTNE
TVCWVHVGDS AAQTQLKCAR MPGLKGFVDE HTINISLSLH HVEQMAIDWL TGNFYFVDDI
DDRIFVCNRN GDTCVTLLDL ELYNPKGIAL DPAMGKVFFT DYGQIPKVER CDMDGQNRTK
LVDSKIVFPH GITLDLVSRL VYWADAYLDY IEVVDYEGKG RQTIIQGILI EHLYGLTVFE
NYLYATNSDN ANAQQKTSVI RVNRFNSTDY QVVTRVDKGG ALHIYHQRRQ PRVRSHACEN
DQFGKPGGCS DICLLANSHK ARTCRCRSGF SLGSDGKSCK KPEHELFLVY GKGRPGIIRG
MDMGAKVPDE HMIPIENLMN PRALDFHAET GFIYFADTTS YLIGRQKIDG TERETILKDG
IHNVEGVAVD WMGDNLYWTD DGPKKTISVA RLEKAAQTRK TLIEGKMTHP RAIVVDPLNG
WMYWTDWEED PKDSRRGRLE RAWMDGSHRD IFVTSKTVLW PNGLSLDIPA GRLYWVDAFY
DRIETILLNG TDRKIVYEGP ELNHAFGLCH HGNYLFWTEY RSGSVYRLER GTGGAPPTVT
LLRSERPPIF EIRMYDAQQQ QVGTNKCRVN NGGCSSLCLA TPGSRQCACA EDQVLDTDGV
TCLANPSYVP PPQCQPGEFA CANSRCIQER WKCDGDNDCL DNSDEAPALC HQHTCPSDRF
KCENNRCIPN RWLCDGDNDC GNSEDESNAT CSARTCPPNQ FSCASGRCIP ISWTCDLDDD
CGDRSDESAS CAYPTCFPLT QFTCNNGRCI NINWRCDNDN DCGDNSDEAG CSHSCSSTQF
KCNSGRCIPE HWTCDGDNDC GDYSDETHAN CTNQATRPPG GCHNDEFQCR LDGLCIPLRW
RCDGDTDCMD SSDEKSCEGV THVCDPNVKF GCKDSARCIS KAWVCDGDSD CEDNSDEENC
ESLACRPPSH PCANNTSVCL PPDKLCDGND DCGDGSDEGE LCDQCSLNNG GCSHNCSVAP
GEGIVCSCPL GMELGPDNHT CQIQSYCAKH LKCSQKCDQN KFSVKCSCYE GWVLEPDGES
CRSLDPFKPF IIFSNRHEIR RIDLHKGDYS VLVPGLRNTI ALDFHLSQSA LYWTDVVEDK
IYRGKLLDNG ALTSFEVVIQ YGLATPEGLA VDWIAGNIYW VESNLDQIEV AKLDGTLRTT
LLAGDIEHPR AIALDPRDGI LFWTDWDASL PRIEAASMSG AGRRTIHRET GSGGWPNGLT
VDYLEKRILW IDARSDAIYS ARYDGSGHME VLRGHEFLSH PFAVTLYGGE VYWTDWRTNT
LAKANKWTGH NVTVVQRTNT QPFDLQVYHP SRQPMAPNPC EANGGRGPCS HLCLINYNRT
VSCACPHLMK LHKDNTTCYE FKKFLLYARQ MEIRGVDLDA PYYNYIISFT VPDIDNVTVL
DYDAREQRVY WSDVRTQAIK RAFINGTGVE TVVSADLPNA HGLAVDWVSR NLFWTSYDSN
KKQINVARLD GSFKNAVVQG LEQPHGLVVH PLRGKLYWTD GDNISMANMD GSNRTLLFSG
QKGPVGLAID FPESKLYWIS SGNHTISRCN LDGSGLEVID AMRSQLGKAT ALAIMGDKLW
WADQVSEKMG TCNKADGSES VVLRNSTTLV MHMKVYDESI QLDHEGTNPC SVNNGDCSQL
CLPTSESTRS CMCTAGYSLR SGQQACEGVG SFLLYSVHEG IRGIPLDPND KSDALVPVSG
TSLAVGIDFH AENDTIYWVD MGLSTISRAK RDQTWREDVV TNGIGRVEGI AVDWIAGNIY
WTDQGFDVIE VARLNGSFRY VVISQGLDKP RAITVHPEKG YLFWTEWGQY PRIERSRLDG
TERVVLVNVS ISWPNGISVD YQDGKLYWCD ARTDKIERID LETGENREVV LSSNNMDMFS
VSVFEDFIYW SDRTHANGSI KRGSKDNATD SVPLRTGIGV QLKDIKVFNR DRQKGTNVCA
VANGGCQQLC LYRGGGQRAC ACAHGMLAED GASCREYAGY LLYSERTILK SIHLSDERNL
NAPVQPFEDP EHMKNVIALA FDYRAGTSPG TPNRIFFSDI HFGNIQRIND DGSGRITIVE
NVGSVEGLAY HRGWDTLYWT SYTTSTITRH TVDQTRPGAF ERETVITMSG DDHPRAFVLD
ECQNLMFWTN WNEQHPSIMR AALSGANVLT LIEKDIRTPN GLAIDHRAEK LYFSDATLDK
IERCEYDGSH RYVILKSEPV HPFGLAVYGE HIFWTDWVRR AVQRANKYVG SDMKLLRVDI
PQQPMGIIAV ANDTNSCELS PCRVNNGGCQ DLCLLTHQGH VNCSCRGGRI LQEDLTCRAV
NSSCRAQDEF ECANGECINF SLTCDGVSHC KDKSDEKPSY CNSRRCKKTF RQCNNGRCVS
NMLWCNGADD CGDGSDEIPC NKTACRVGEF RCRDGTCIGN SSRCNQFVDC EDASDEMNCS
ATDCSSYFRL GVKGVRFQPC ERTSLCYAPS WVCDGANDCG DYSDERDCPG VKRPRCPLNY
FACPSGRCIP MSWTCDKEDD CEHGEDETHC NKFCSEAQFE CQNHRCISKQ WLCDGSDDCG
DGSDEAAHCE GKTCGPSSFS CPGTHVCVPE RWLCDGDKDC ADGADESIAA GCLYNSTCDD
REFMCQNRQC IPKHFVCDHD RDCADGSDES PECEYPTCGP NEFRCANGRC LSSRQWECDG
ENDCHDQSDE APKNPHCTSP EHKCNASSQF LCSSGRCVAE ALLCNGQDDC GDGSDERGCH
VNECLSRKLS GCSQDCEDLK IGFKCRCRPG FRLKDDGRTC ADVDECSSTF PCSQRCINTH
GSYKCLCVEG YAPRGGDPHS CKAVTDEEPF LIFANRYYLR KLNLDGSNYT LLKQGLNNAV
ALDFDYREQM IYWTDVTTQG SMIRRMHLNG SNVQVLHRTG LSNPDGLAVD WVGGNLYWCD
KGRDTIEVSK LNGAYRTVLV SSGLREPRAL VVDVQNGYLY WTDWGDHSLI GRIGMDGSGR
SVIVDTKITW PNGLTLDYVT ERIYWADARE DYIEFASLDG SNRHVVLSQD IPHIFALTLF
EDYVYWTDWE TKSINRAHKT TGTNKTLLIS TLHRPMDLHV FHALRQPDVP NHPCKVNNGG
CSNLCLLSPG GGHKCACPTN FYLGSDGRTC VSNCTASQFV CKNDKCIPFW WKCDTEDDCG
DHSDEPPDCP EFKCRPGQFQ CSTGICTNPA FICDGDNDCQ DNSDEANCDI HVCLPSQFKC
TNTNRCIPGI FRCNGQDNCG DGEDERDCPE VTCAPNQFQC SITKRCIPRV WVCDRDNDCV
DGSDEPANCT QMTCGVDEFR CKDSGRCIPA RWKCDGEDDC GDGSDEPKEE CDERTCEPYQ
FRCKNNRCVP GRWQCDYDND CGDNSDEESC TPRPCSESEF SCANGRCIAG RWKCDGDHDC
ADGSDEKDCT PRCDMDQFQC KSGHCIPLRW RCDADADCMD GSDEEACGTG VRTCPLDEFQ
CNNTLCKPLA WKCDGEDDCG DNSDENPEEC ARFVCPPNRP FRCKNDRVCL WIGRQCDGTD
NCGDGTDEED CEPPTAQTPH CKDKKEFLCR NQRCLSSSLR CNMFDDCGDG SDEEDCSIDP
KLTSCATNAS ICGDEARCVR TEKAAYCACR SGFHTVPGQP GCQDINECLR FGTCSQLCNN
TKGGHLCSCA RNFMKTHNTC KAEGSEYQVL YIADDNEIRS LFPSHPHSAY EQAFQGDESV
RIDAMDVHVK AGRVYWTNWH TGTISYRSLP PAAPPTTSNR HRRQIDRGVT HLNISGLKMP
RGIAVDWVAG NVYWTDSGRD VIEVAQMKGE NRKTLISGMI DEPHAIVVDP LRGTMYWSDW
GNHPKIETAA MDGTLRETLV QDNIQWPTGL AVDYHNERLY WADAKLSVIG SIRLNGTDPI
VAADSKRGLS HPFSIDVFED YIYGVTYINN RVFKIHKFGH SPLINLTGGL SHASDVVLYH
QHKQPEVTNP CDRKKCEWLC LLSPSGPVCT CPNGKRLDNG TCVAVPSPTP PPDAPRPGTC
NLQCFNGGSC FLNARRQPKC RCQPRYTGDK CELDQCWEYC RNGGTCAASP SGMPTCRCPT
GFTGPKCTQQ VCAGYCANNS TCTVNQGNQP QCRCLPGFLG DRCQYRQCSS YCENFGTCQM
AADGSRQCRC TAYFEGPRCE VNKCSRCLDG ACVVNKQSGD VTCNCSDGRV APSCLTCVGH
CSNGGSCTMN SKMMPECQCP PHMAGPRCEE QVVSQQQPGH MASILIPLLL LLLVLLVAGV
VFWYKRRVRG AKGFQHQRMT NGAMNVEIGN PTYKMYEGGE PDDVGGLLDA DFALDPDKPT
NFTNPVYATL YMGGHGSRHS LASTDEKREL LGRGPEDEIG DPLA
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