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Database: UniProt
Entry: M3VUC1_FELCA
LinkDB: M3VUC1_FELCA
Original site: M3VUC1_FELCA 
ID   M3VUC1_FELCA            Unreviewed;      1785 AA.
AC   M3VUC1;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN11A {ECO:0000313|Ensembl:ENSFCAP00000000217};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000217, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000000217, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000000217}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000000217}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000217};
RG   Ensembl;
RL   Submitted (MAR-2013) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AANG03347405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AANG03347409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9685.ENSFCAP00000000217; -.
DR   Ensembl; ENSFCAT00000000236; ENSFCAP00000000217; ENSFCAG00000000236.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; M3VUC1; -.
DR   OMA; CYQIVKH; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000011712; Chromosome C2.
DR   Bgee; ENSFCAG00000000236; -.
DR   GO; GO:0044299; C:C-fiber; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0051930; P:regulation of sensory perception of pain; IEA:Ensembl.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028821; Na_channel_a11su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF210; PTHR10037:SF210; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    128    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    163    184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    196    212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    233    254       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    260    279       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    374    393       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    579    597       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    609    632       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    702    725       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    809       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1055   1073       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1094   1113       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1119   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1164   1190       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1285   1308       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1358   1381       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1401   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1431   1449       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1486   1514       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1534   1557       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1578   1604       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      131    410       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      579    818       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      827   1049       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1053   1316       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1365   1614       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      404    435       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1785 AA;  203390 MW;  B82404ABC12BFDBA CRC64;
     MDDRCYPVIF PDERNFRPFT SDTLATIEKR IAIQKEKKKC KDQTPAEPQP RPQLDLKVSR
     KLPKLYGNIP HELIARPLED LDPFYRNHKT FMVLNKKRTI YRFSANRALF VFGPFNPIRS
     LAIRISTAVT LFSMFIICTV IINCVFMATA CGKDNSNIYT DNAEYVFTGI YIFEALIKIL
     ARGFVLDEFS FLRDPWNWLD SIVIATAFVS YSPSIRASGI SLSSLRTFRV FRALKAISVV
     SGLKVIVGAL LRSVKKLVDV MILTLFCLSI FALVGQQLFK ENLNQRCVRK DCKDMDNLDD
     HCFEKKDSTE FRICGSWMGE SACSEQFQCN HTKRNPDYNY TNFDNFGWSF LSMFRLITQD
     SWEKLYQQTL RTSGLFSVFF FVVVIFLGSF YLINLTLAVV TMAYEEQNRN VAAETEAKEK
     MFQEAQRLLK EEKEALVAMG IDRSSLNSLE ASSFSPKKRK LFGNRKRKSF ILRDSGKDQP
     PESDSDEDST KKPHILEQTK RLSQNLSVDF CDEHGDPFQR QRALSAVSIL TITMQEQEKS
     QEPCLPCGGN VASRYLVWNC SPQWLCIKKA LRVVMTDPFT ELVITICIVI NTVFLALEHY
     KMDQSFEYML YTGNLVFTGI FMAEMCLKII ALDPYNYFRR GWNIFDSIVA LLSFADVMNS
     VVVGKQSPLF FHSLRVLRVF KLAKSWPTLN TLIKIIGHSV GALGNLTVVL AIVVFIFSVV
     GMQLFGSKFN SVRNNTKSCG PTVPCLRRWH MGDFYRSFLV VFRILCGEWI ENMWECMQET
     SKPLCVVVFL LIMVIGKLVV LNLFIALLLN SFSNEERDGS LDGEAKKTKV QLALDRFHRA
     FCFVIHTLAR FCHTWCRRQT LPQQKEVSGD PPAKSKDIIP LVAGVKRGSE TWEEFGVVTS
     APKTLSVEHD RTWLAPLAEE EDDFESSGKI NAQCIAPPEA GKQAYELPQE TKTSTSPGAQ
     SVEIDVFSEG DIYLSAQNTR KKSDTTSVFS ECSTIDPQDP FARVPEMVPK KEPERCFPKG
     LGHCFPCCAT DKRKSHWIIW WNLRKTCYQI VKHSWFESFV IFVILLSSGA LVFEDIHLEK
     RPNIQALLNC TDHIFTYIFI LEMGLKWVAF GFGKYFTSVW CWLDFIIVIV SVTSLIDLKS
     LKSFRTLRAL RPLRALSQFE GMKVVVNALI GAIPAILNVL LVCLIFWLIF CILGVNFFSG
     KFGRCINVSD TNSVINYSVV ANQSQCESGN FSWVTPPVNF DNVGMAYLAL LQVATFKGWM
     DIMYAAVDSR GKELQPGFEE NPQNYLFFVA FIIFGSFFTL NLFIGVIIDN FNQQQKKISG
     EDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PLNKCQGLAF DLVTNQVFDV IIIILIFLNM
     VIMMAESNNH PEDTKAILEE LNLAFVVIFT IECLIKIFAL RQYYFTNGWN LFDCVIVVLS
     IVSAMVSALE NQQHIPFPPT LFRVVRLARI GRILRLVRAA RGIRTLLFAL MMSLPSLFNI
     GLLLFLVMFI YAIFGMNCFC KVKEGFGIDD IFNFKTFVGS ILCLFQITTS AGWDALLRPM
     LQSNDSCNPN LDSRHLPAIA IAYFVSYIII SFLIVVNMYI AVILENFNTA TEESEDPLGE
     DDFEIFYEVW EKFDPEATQF IKYPALSDFA DALPEPLRVA KPNRFQFLMM DLPMVSGDRL
     HCLDILFAFT TRVLGNSSGL DSMKAMMEEK FMEANPSKKL YEPIVTTTKR KEEERCAAVI
     QKAFRKYKLK MSMGALEDGP RSPLQTLCNG DLSSSGVAEG KVHYD
//
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