ID M3VUP3_FELCA Unreviewed; 495 AA.
AC M3VUP3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|Ensembl:ENSFCAP00000000369.5};
GN Name=ENTPD2 {ECO:0000313|Ensembl:ENSFCAP00000000369.5,
GN ECO:0000313|VGNC:VGNC:61879};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000000369.5, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000000369.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000369.5,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000000369.5, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000369.5,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000000369.5}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000000369.5};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; AANG04000104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3VUP3; -.
DR STRING; 9685.ENSFCAP00000000369; -.
DR PaxDb; 9685-ENSFCAP00000000369; -.
DR Ensembl; ENSFCAT00000000399.6; ENSFCAP00000000369.5; ENSFCAG00000000399.6.
DR VGNC; VGNC:61879; ENTPD2.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263542; -.
DR HOGENOM; CLU_010246_2_0_1; -.
DR InParanoid; M3VUP3; -.
DR OMA; NEECRYQ; -.
DR Proteomes; UP000011712; Chromosome D4.
DR Bgee; ENSFCAG00000000399; Expressed in prefrontal cortex and 8 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:Ensembl.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR GO; GO:0030168; P:platelet activation; IEA:Ensembl.
DR GO; GO:0009181; P:purine ribonucleoside diphosphate catabolic process; IEA:Ensembl.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 464..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 204..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 495 AA; 53780 MW; 430CE293865D7ACC CRC64;
MAGKVLSLLP PLLLAAAGLA GLLLLCVPTR DIWELPALKY GIVLDAGSSH TSMFIYKWPA
DKENDTGIVG QHSSCNVRGG GISSYADDPS RAGQSLVECL DQALQEVPKE SHVHTPLYLG
ATAGMRLLNL TSPEASANVL AAVTRTLTRY PFDFRGAHIL SGQDEGVFGW VTANYLLENF
IKYGWVGRWF RPRKGTLGAM DLGGASTQIT FETASPAEDP ANEVRLRLYG QHYCVYTHSF
LCYGRDQVLR RLLAGALQTH GFHPCWPRGY STQVLLQDVY ESPCTAAQRP QTFNSSTRVS
LAGSSDPALC RGLILGLFNF SSCRFSRCSF NGIFQPPVAG NFMAFSAFFY TVDFLRSVMG
LPVATLQQLE TAVVAVCNQT WSQLQAKAPG QRARLPDYCA GAMFVQQLLS RGYGFDERAF
GGVTFQSKAG DTAVGWALGY MLNLTNLIPA EPPELRKGTD FRSWVALLLL FAAMLLAAVV
LLLRQARSAG ASSAI
//